Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Loin pain may be a major presenting symptom in patients with glomerulonephritis. Most of these patients show an underlying focal and segmental proliferative glomeruloneyphritis and there may be associated deposits of IgA and Igg in the mesangium. In this group of patients, vascular lesions are often prominent in the absence of hypertension. Episodes of recurrent macroscopic hematuria also occur, but the pain cannot be attributed to colic due to blood clots in the ureter.
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PMID:Loin pain as a presenting symptom in idiopathic glomerulonephritis. 12 72

Two patients with previously undescribed renal manifestations of Wegener's granulomatosis are described. A 24 year old man, who presented with typical necrotizing granulomatous sinus disease and cavitary pulmonary lesions, had multiple bilateral renal arterial aneurysms demonstrated angiographically. One of these aneurysms ruptured, leading to a massive perinephric hematoma. The bleeding artery was successfully occluded with Gelfoam embolization, thereby obviating the need for nephrectomy. A 60 year old woman presented with glomerulonephritis and mononeuritis multiplex two years before the development of classic necrotizing granulomatous inflammation of her sinuses and nose, along with pulmonary nodules. In addition, her left ureter became obstructed due to necrotizing vasculitis of the periureteral vessels. Both patients responded dramatically to cyclophosphamide therapy. The diagnosis of Wegener's granulomatosis should be considered in patients who present with multiple renal aneurysms, a spontaneous perinephric hematoma, necrotizing glomerulitis or ureteral obstruction due to vasculitis, even though the characteristic granulomatous respiratory involvement may be absent at that time. It is important to recognize these unusual renal manifestations as features of Wegener's granulomatosis because of the therapeutic efficacy of cytotoxic immunosuppressive agents in this disease.
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PMID:Unusual renal manifestations of Wegener's granulomatosis. Report of two cases. 64 52

Fresh urine samples from twenty patients with macroscopic haematuria were examined by phase contrast microscopy to study the erythrocyte morphology. Other appropriate investigation like - renal biopsy in suspected glomerulonephritis and appropriate urological investigations in other cases to prove the site of origin of erythrocyte were done in all cases. Changes in erythrocyte morphology were observed in all the 12 patients with histological evidence of proliferative glomerulonephritis. These changes included extrusion of cell cytoplasm (39.5%), 'Doughnut' cell (26.5%) budding cell (15%) and cell membrane rupture with loss of cytoplasm (15%). Overall 83.3% of the erythrocytes showed some morphologic change or the other. In 8 patients where bleeding was into the pelvicalyceal system, ureter or bladder, 95% of RBCs showed no discernible morphologic change. It is concluded that the morphological changes in the erythrocyte identified under the phase contrast microscope can help to differentiate between glomerular and non glomerular causes of bleeding.
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PMID:Erythrocyte morphology under phase contrast microscopy in haematuria. 262 Nov 88

Of 18 pregnancies in 11 renal transplant recipients, three were terminated and in the remaining 15 (in 8 women) there were 10 live births (including one set of twins), five intrauterine deaths, and one spontaneous abortion. Graft function deteriorated in six women, from obstruction of the transplanted ureter in two, recurrent glomerulonephritis in two, rejection in one, and pelvi-ureteric junction obstruction in one. Hypertension worsened or developed in all but one of the pregnancies and proteinuria appeared in eight. Of the 10 live births only one reached 38 weeks gestation (mean 35 weeks) and four neonates were small for gestational age. One infant died early from intraventricular hemorrhage and hyaline membrane disease, one fetus had hydrocephalus, and the others were normal. Factors associated with a poor fetal outcome were deterioration in graft function during pregnancy, pre-existing hypertension, or the development of hypertension before the third trimester.
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PMID:Problems associated with pregnancy in renal allograft recipients. 266 32

A thirty-three-year-old woman was evaluated for eosinophilia, irritative bladder symptoms, and renal insufficiency. Eosinophilic cystitis was documented by bladder biopsy and glomerulonephritis by renal biopsy. As the glomerulonephritis and other symptoms resolved, unilateral ureteral obstruction developed with irreversible loss of right renal function. The distal ureter was found to have eosinophilic infiltration. This entity should be considered in the differential diagnosis of unilateral ureteral obstruction associated with cystitis.
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PMID:Ureteral involvement complicating eosinophilic cystitis. 401 85

Rejection processes concerning transplanted kidneys are traditionally classified as hyperacute, acute and chronic. It is, however, generally felt, that this time related classification is not satisfactorily in every respect. In order to come to a more differentiated histological diagnosis in the individual case, we resolved the time related classification categories and tried to specify rejection processes exclusively according to pathomorphological aspects. Thus 3 morphological rejection patterns or types can be differentiated: (1) a necrotizing-thrombotic rejection type (nth-rej), (2) a cellular rej (cell-rej) and (3) a sclerosing rej (scl-rej). These morphological rejection types match only partially with the time related categories. Especially it becomes apparent, that many cases have mixed rejection patterns. The pure as well as the mixed rejection patterns can exactly be defined in the histological diagnosis when the morphological categories are applied (e.g. severe cell-rej with moderate nth- and slight scl-component). This procedure is favourable in our opinion because a) the histological diagnosis now precisely informs the clinician about the whole spectrum of lesions present and b) individual cases can be compared with one another more effectively. In biopsy interpretation especially the following causes of functional deterioration have to be considered besides rejection processes: shock kidney, ureter stenosis, pyelonephritis, renal artery thrombosis and various types of glomerulonephritis (GN) in the transplant (de novo-GN, recurrent GN and others).
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PMID:[Pathomorphology of transplant rejection and kidney biopsy diagnosis of the transplant]. 675 47

Phase-contrast microscopy of the urine of a young Greek woman with macroscopic haematuria showed sickling of the red blood cells. The diagnosis of sickle-cell trait was confirmed with haemoglobin electrophoresis, and an intravenous pyelogram demonstrated the typical medullary cavities seen in this disease. Urine collected from the left ureter, from which the haematuria originated, grew 10(6) Ureaplasma urealyticum/ml. With Doxycycline therapy the macroscopic haematuria and the sickled cells in the urine resolved, but red cell casts and an excessive number of glomerular red blood cells persisted in the urine, confirming the presence of glomerulonephritis. Ureaplasma urealyticum has not previously been described in association with a sickling episode nor with the scarring of a sickle cell kidney. The possible role of this infection is discussed.
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PMID:Haematuria associated with ureaplasma infection in sickle-cell trait. 695 41

The rationale of the somatic gene therapy is the correction of diseases at the most fundamental level. Ideal gene therapy should be achieved by the replacement of the wrong gene sequence of genome with correct one. However, the gene technology to date is yet immature so as to correct the wrong gene sequence in vivo. Potentially, the present technology of gene transfer may provide: 1) correction of cellular dysfunction by expressing the deficient gene; 2) addition of new function for a cell by transferring an exogenous gene; 3) inhibition of unfavorable action of a cell by introducing a counteracting gene. In nephrology, the gene transfer targeted kidney has been challenged at the experimental level. HVJ-liposome method and recombinant adenovirus allow gene transfer to the particular cells in kidney in vivo. Ex vivo gene transfer using mesangial cells and macrophages are another option. Transplant kidney is also a good material for genetic engineering. The potential application of gene transfer is enormous while the therapeutic application have just begun to explored. We have been devoted to HVJ-liposome mediated gene transfer to the kidney and successfully demonstrated the suppression of the extracellular matrix accumulation of the glomeruli in the experimental glomerulonephritis through inhibition of the TGF-beta action by antisense oligonucleotides or soluble type receptor chimera for TGF-beta. We also applied this technology to the inhibition of interstitial fibrosis in unilateral ureter obstruction model. The new HVJ-liposome method improved in lipid composition allows gene transfer to tubulointerstitial fibroblast by retrograde approach from ureter. In consequence, introduced TGF-beta antisense suppressed the TGF-beta mRNA in concomitant with ameliorating interstitial fibrosis. We believe that the gene transfer technique will become common strategy to study the molecular aspect of the renal diseases and will be possibly applicable to molecular intervention in nephrology.
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PMID:Towards gene therapy for renal diseases. 985 74

A 63-year-old man with rapidly progressive glomerulonephritis of the immune-complex type showed typical findings of idiopathic retroperitoneal fibrosis involving the left ureter resulting in hydronephrosis. Treatment with steroid improved both conditions. Our case and previously reported cases showing the same association of conditions support the hypothesis that the association is not fortuitous but reflects a common immunological mechanism.
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PMID:Retroperitoneal fibrosis and immune-complex glomerulonephritis. 1139 86

Henoch-Schonlein purpura (HSP) is a systemic vasculitic disorder involving both arterioles and capillaries. Although mainly a disease of early childhood, it can occur at any age. HSP is typically recognized as a syndrome with four major components: rash, joint manifestations, abdominal symptoms and renal disease. It is usually a mild condition with a tendency to relapses and generally has a good prognosis. Occasionally, however, it takes on an aggressive course. Gastrointestinal involvement is potentially the most serious complication of HSP. It may mimic an abdominal emergency and in its severest form result in small bowel infarction and/or perforation. Renal manifestations range from asymptomatic haematuria and/or proteinuria through a nephrotic syndrome to progressive glomerulonephritis leading to end stage renal failure. Apart from the major components outlined above, HSP may affect almost every other bodily organ. Vasculitis involving the myocard, lungs (pulmonary haemorrhage), ureter (stenosing ureteritis) and nervous system have been reported. We describe a case of HSP in a 50 year old woman which was complicated by the development of necrotizing crescentic glomerulonephritis and a left hemiparesis due to cerebral vasculitis. Interestingly, this patient had first appeared at the age of 9 years with a nephrotic syndrome and had been diagnosed by renal biopsy at the age of 31 as IgA nephropathy (IgAN). On her current admission, steroid and immunosuppressive therapy resulted in an improvement of renal function and an almost complete disappearance of her neurologic deficit.
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PMID:[Crescentic glomerulonephritis and cerebral vasculitis in the course of Henoch-Schonlein purpura]. 1247 29


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