Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The risk of second primary cancer was evaluated in 29,128 patients who developed tumors of the urinary tract, including benign and malignant tumors of the renal pelvis and ureter and bladder papillomas in Denmark between 1943 and 1980. Among 9,162 persons with kidney cancer, 416 developed a second primary tumor [relative risk (RR) = 1.4]. Among 19,966 persons with bladder cancer, 1,423 developed a second primary tumor against 1,239 expected (RR = 1.1). The risk of bladder cancer was increased following kidney cancer in both men (RR = 6.3) and women (RR = 10.1), and kidney cancer was increased in both men (RR = 2.9) and women (RR = 4.5) following bladder cancer. These risks were particularly pronounced for cancers occurring in the ureter and renal pelvis. Etiologic similarities are likely explanations for these observations, which also emphasize the role of host factors and the multifocal nature of urothelial tumors. A decrease in relative risks since diagnosis of the first primary cancer was seen that may partly be attributed to a lessening of the intensity of medical surveillance with time. Among long-term survivors with kidney cancer, increased risks were observed for colon and pancreatic cancers, which may be related to treatment; approximately 25% received radiotherapy. Among bladder cancer patients, increased risks of cancers of the lung and larynx occurred, probably due to tobacco smoking. A slight elevation of prostate cancer (RR = 1.3) may be attributable to medical surveillance. Unexpected findings were the significant deficits of cancers of the stomach and rectum among patients with bladder cancer and stomach cancer among those with kidney cancer.
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PMID:Second cancer following cancer of the urinary system in Denmark, 1943-80. 408 9

Supravesical urinary diversion by ureterotransversopyelostomy (UTPS) with unilateral nephrostomy was performed in 57 patients. The age of the 33 women ranged between 42 and 86 (mean 65), of the 24 men between 39 and 77 (mean 62) years. With a single exception, the indication for diversion was palliative: 25 patients had advanced bladder cancer (T3/T4), and 19 had undergone irradiation; 24 patients showed vesico- (recto-) vaginal fistulas due to radiation for gynecological carcinomas. In 2 patients, the indication was urge-incontinence following former radiation therapy for uterine cancer, whereas 5 patients had advanced malignancies originating in the urethra, prostate, rectum or ovaries. The only case without malignant disease exhibited a contracted bladder of uncertain origin, together with an immunodeficiency syndrome. The approach used was an upper abdominal cross incision. In 35 patients, an anastomosis was done between the ureter and contralateral renal pelvis; in 22, a terminoterminal ureteral anastomosis was performed. For placement of the nephrostomy (49 terminal, 8 U-tube nephrostomies) we preferred the right side in 41 of 57 cases. The mean follow-up time in the 22 surviving patients was 36 months (range 2-108); the mean survival time in the 30 deceased patients was 12 months (range 0.5-87). With 4 exceptions, the cause of death was progression of the underlying tumors. Operative lethality was 1.75%, early surgical complication rate 7%, and rate of severe late complications 10.5%. The most frequent problems arose from the nephrostomy and from stenoses of the ureteropelvic or ureteral anastomosis.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Ureterotransversopyelostomy with unilateral nephrostomy]. 409 Jan 30

A variant form of urinary arylsulfatase A which was not detected in normal voided urine was demonstrated in the urine obtained directly from the renal-pelvis [Ishibashi, T. et al.: Biochim. Biophys. Acta, 616, 218-227 (1980)]. The variant form was not observed in urine collected directly from the ureter during operations for uretero-cutaneostomy or ileal conduit. However, the urine from intubated uretero-cutaneostomy patients collected near the pelvi-ureteric junction showed the presence of the variant form, further suggesting the origin specificity of the variant. This arylsulfatase was not demonstrated in the voided urine from patients with non-urologic malignant disorders such as uterine endometrial, uterine cervical, rectal, pancreas head and gastric carcinomas, in spite of its appearance in high levels in the urine from patients with advanced bladder cancer.
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PMID:Clinical significance of a variant form of urinary arylsulfatase A. 614 12

A screening test for detecting antibodies to HSV-TAA was performed on 26 sera, from urinary bladder carcinoma patients and on 30 sera from prostatic carcinoma patients. Positive results were found in 50% of the urinary bladder cancer sera and in 60% of the prostatic carcinoma sera. As control 10/11 sera from benign prostatic hypertrophy and 4/4 sera from renal pelvis or ureter neoplasias (tumors never previously associated to HSV) were negative before and after surgery. The only one positive of the former group became negative after surgical treatment. The TAF-test can therefore be a meaningful test for monitoring antibody levels in the sera of patients before, during or after the treatment, in order to evaluate the presence of metastases or the success of a therapy.
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PMID:TAF-test: a tumor diagnosis device in oncologic urology. 618 64

A current problem in urology involves the search for a method of high urine bypass which combines simplicity of application with therapeutic efficacy. A new technique of direct cutaneous ureterostomy is described which is applicable to both narrow and dilated ureters, and which prevents stenosis without catheterization. The originality of the method resides in the association of two previously described artifices. The first is related to the parietal crossing and involves interlocking of the aponeuroses of the external oblique and transverse abdominal muscles with resulting displacement of the internal oblique muscle fibers outside of the parietal course of the ureter. The second artifice concerns the ureterocutaneous anastomosis, with the formation of a skin flap in V sutured to the terminal portion of the axially incised ureter, the point of the V being attached to the apex of the incision. Ureteral vascularization must be respected and a sufficient length of ureter used to ensure anastomosis without traction. An indwelling ureteral catheter is maintained for one month, followed by urographic and ultrasonographic surveillance at progressively increasing intervals. This operative procedure was used in 23 patients (21 men and 2 women), age 48 to 74 years, with bladder cancer necessitating total enlarged cystoprostatectomy. Bilateral cutaneous ureterostomy was performed in 19 cases, and the unilateral operation (single kidney) in 4 patients. Of the 41 ureters on which a bypass was performed, 31 were initially narrow and 10 dilated. Overall results for 41 ureters showed that 34 (82,9%) were permeable after 18 months, a catheter having to be maintained in 7 cases only (17,1%).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Direct cutaneous ureterostomy: a new technic. Preliminary results]. 638 14

Activity of urinary N-acetyl-beta-D-glucosaminidase (NAG) has been studied in patients with urological diseases. In most patients with benign prostatic hyperplasia, prostate cancer and bladder cancer, activity of urinary NAG was elevated (92.9%), especially in cases of indwelling catheterization or poor visualization of IVU. Urinary NAGs were also elevated for all patients with renal stones, ureter stones, uretero-cutaneous stomy or a single kidney. In hydronephrosis or hydronephrosis with hydroureter patients, urinary NAG level was low pre-operatively, but increased post-operatively. Urinary beta 2-microglobulin (BMG) showed a similar tendency in patients with hydronephrosis or hydronephrosis with hydroureter. Electronmicroscopic observations of the kidney in such patients revealed many primary and secondary lysosomes.
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PMID:[Urinary excretion of N-acetyl-beta-D-glucosaminidase in patients with urological disease: with special reference to hydronephrosis]. 639 Nov 19

Circulating immune complexes (CIC) were detected and quantitated in 49 patients with urological malignant diseases (9 cases of renal cell cancer, 3 cases of renal pelvic and ureter cancer, 21 cases of bladder cancer and 16 cases of prostatic cancer), 9 patients with urological benign diseases and in normal subjects by the polyethylene-glycol precipitation complement consumption test (PEG-CC test). The average CIC level was 2.7 +/- 3.0% in 18 normal subjects and the normal range was less than 10% of the CIC level. CIC level of patients with renal cell cancer was 14.3 +/- 20.1%, being elevated in 3 of the 9 patients, that of patients with renal pelvic and ureter cancer was 4.7 +/- 4.6%, being within the normal range in 3 cases, that of patients with bladder cancer was 4.7 +/- 4.4%, being elevated in 1 of 21 patients, and that of patients with prostatic cancer was 8.9 +/- 15.4%, being elevated in 3 of 16 patients. In urological malignant diseases such as renal cell cancer and prostatic cancer the CIC values were relatively high.
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PMID:[Detection of circulating immune complexes by polyethyleneglycol precipitations complement consumption test in urological malignant diseases]. 654 90

Two theories of pathogenesis of multifocal transitional cell carcinoma are discussed: 1. Theory of cellular implantation; 2. multifocal tumor growth. The increased incidence of tumors in the upper urinary tract after urinary diversion for bladder cancer supports the multifocal theory. After treatment of papillary bladder cancer the risk of developing a second tumor in the kidney or ureter is much higher. Therefore we emphasize the continuous follow-up with radiological control of the upper urinary tract.
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PMID:[Increased risk of tumor development in the upper urinary tract following multicentric papillary bladder tumors]. 668 1

Serious urinary and bowel complications after ileal conduit diversion are associated with significant morbidity and mortality rates. We reviewed 9 patients treated at our institution during the last 5 years for sequelae after ileal conduit diversion for bladder cancer. Of these patients 8 are well and 1 died postoperatively of a myocardial infarction. In all, 33 operations were required to treat complications after initial diversion. A variety of surgical procedures, including anastomotic revision, ileal ureter, stomal revision, transverse colon conduit and nephrectomy, was used to treat urinary complications. A treatment outline emphasizing an initial conservative approach, the importance of nutritional support and the appropriate options for reconstruction is presented.
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PMID:Management of urinary and bowel complications after ileal conduit diversion. 715 68

In 300 urological patients with long-term intake of phenacetin-containing compounds, renal (papillary necrosis, chronic interstitial nephritis) and extrarenal manifestations appeared after an average latency period of 20 years. Course and prognosis primarily depend on the successful cessation of analgesics and the elimination of the accompanying infection. In the last decade, an increase of transitional cell carcinoma induced by analgesics has been observed. 31 of our patients presented a tumor of the urothelium (i.e. 10.3%) 26 patients presented isolated carcinoma of the bladder, 2 persons were diagnosed as having cancer of the bladder and the renal pelvis, and 1 patient had cancer of the bladder and the ureter. Only 2 persons suffered from isolated carcinoma of the renal pelvis. A further increase of these specific cases if expected.
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PMID:Analgesic nephropathy and phenacetin-induced transitional cell carcinoma - analysis of 300 patients with long-term consumption of phenacetin-containing drugs. 728 4


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