Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This is a report of a 22-year-old woman who suffered from a loss of urine via the vagina of unknown origin since childhood. The diagnosis of a left ureteral and renal duplication with an opening of an ectopic ureter into the cervix was established. Due to the result of the retrograde pyelogram we came to the conclusion that the opening into the cervix must have been via a segment of a Gartner duct. The ectopic system and the Gartner duct were completely removed by a combined abdomino-vaginal operation. Genesis, diagnostics, differential diagnostics and therapy of ectopic ureters are described.
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PMID:[An ectopic ureter with communication to the duct of Gartner and opening into the cervix--a rare cause of uncontrolled urine loss]. 781 79

The embryonic kidney is a classic developmental model system for studying inductive tissue interactions that govern organogenesis. We report here that Wnt-6 is expressed in the ureter bud, and that cell lines expressing Wnt-6 induce nephrogenesis in vitro. Wnt-6 cells induce tubules with similar kinetics to spinal cord (SPC) and lead to induced expression of Pax2, Pax8, Sfrp2, and E-cadherin genes, early markers of tubulogenesis. Moreover, Wnt-6 signaling rescues tubulogenesis in mesenchyme separated from Wnt-4 mutant embryos and leads to activation of Wnt-4 transcription. Wnt-6 also induces a secondary axis in early Xenopus embryos. We conclude that Wnt-6 is a candidate for the ureter epithelium-derived signal that leads to activation of kidney tubulogenesis via Wnt-4.
Genesis 2002 Apr
PMID:Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro. 1194 13