Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Close phenotypic similarity between two cases carrying a rec(3) dup q,inv(3) (p25q21), 12 additional infants from the same inv (3)(p25q21) kindred who lived less than 1 year, and eight cases studied in other medical centers has led us to postulate the existence of a distinct chromosome 3 duplication-deletion syndrome. In the presence of trisomy for (3)q21 leads to qter and monosomy for (3)p25 leads to pter, the facial dysmorphy is unique: a distorted head shape due to irregular cranial sutures, thick low eyebrows, long eyelashes, persistent lanugo, distended veins on the scalp, hypertelorism, oblique palpebral fissures, a very short nose with a broad depressed bridge and anteverted nares, protruding maxilla, thin upper lip, micrognathia, low-set ears, and a short webbed neck. Port-wine stains, congenital glaucoma, cloudy corneas, cleft palate and harelip also occur frequently. Each infant has difficulty sucking and swallowing. Congenital anomalies of the cardiovascular system, of midgut rotation, and of the urogenital system are noted for the infants who died neonatally. Most frequent is a ventricular septal defect, followed by atrial septal defect, patent ductus arteriosus, patent foramen ovale, and coarctation of the aorta. Omphalocele, umbilical hernia, hyperplastic kidneys, polycystic kidneys, double ureter, hydro-ureter, hydronephrosis, and undescended testes often occur. The extremities are short in proportion to the length of the trunk. Clinodactyly, coxa valga, talipes, and spina bifida are frequently observed.
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PMID:Chromosome 3 duplication q21 leads to qter deletion p25 leads to pter syndrome in children of carriers of a pericentric inversion inv(3) (p25q21). 120 27

The physical, haematological, urinary and radiographic findings in a female pekingese dog with right renal aplasia are described. The right ureter was present and structurally normal. The left kidney was hypertrophied. The ovaries and uterus were normal.
Vet Rec 1975 Dec 13
PMID:In-vivo diagnosis of right renal aplasia in a pekingese bitch. 120 38

Ectopic ureter in the dog is only sporadically reported. A case in an adult golden retriever is described.
Vet Rec 1976 Apr 10
PMID:Ectopic ureter in the bitch. 127 40

The purpose of this study is to demonstrate the developmental changes of the experimental hydronephrotic kidney using immunohistochemical, histoplanimetrical, and Northern blot techniques. At 1 month after ligation of the ureter, a large number of renin-positive cells were detected immunohistochemically even at a dilution of 1:10,000 in this hydronephrotic kidney; however, there were few renin-positive cells in the non-ligated side. At 6 months after ligation, no difference in reactivity for renin between ligated and non-ligated kidneys was demonstrated. In the morphometrical analysis of the renin-positive region, the numerical value of the ligated side was already increased at 2 weeks, reached the highest value at 1 month, and then decreased gradually to almost the same value as the control kidney by the end of the experiment. On the other hand, the value of the non-ligated side decreased immediately after the unilateral ligation, increased later, and finally reached almost the same value as the control kidney. In the Northern blot analysis, the activity of renin mRNA in the ligated side at 1 month after ligation was markedly higher than that in the non-ligated side. However, the difference between the ligated and the non-ligated sides was not demonstrated at 6 months and the value came to be almost the same as in the non-operated kidney.
Anat Rec 1992 Mar
PMID:Morphological and northern blot analysis of juxtaglomerular cells in experimental hydronephrotic mice. 154 64

The case histories of 175 dogs with ureteral ectopia were reviewed; there were 156 females and 19 males. Golden retrievers, labrador retrievers and Skye terriers appeared to be over-represented. Their median age when examined was 10 months, and the males were significantly older than the females. Fifty-six animals were affected bilaterally, 50 were affected on the left side alone and 69 on the right side alone. One hundred and twenty-two cases had other abnormalities and 67 had more than one; they included hydro-ureter, hydronephrosis, pyelonephritis, bladder hypoplasia and congenital incompetence of the urethral sphincter mechanism. Forty-one cases were not treated, and the other 134 were treated by ureteronephrectomy, extravesicular ureteric transplantation or intravesicular ureteric transplantation. One hundred and twelve cases were available for follow-up for a median period of over two years (range one month to 15 years). The response to surgery and the incidence of complications was similar after each method of treatment. Sixty-five of the 112 cases were cured of incontinence and 26 were improved. The complication rate (14 per cent overall) was similar for each procedure although different types of complications occurred. Hydronephrosis occurred most commonly after extravesicular transplantation and dysuria occurred most commonly after intravesicular transplantation.
Vet Rec 1995 Apr 08
PMID:Canine ureteral ectopia: an analysis of 175 cases and comparison of surgical treatments. 761 May 37

A healthy, pregnant Diceros bicornis (No. 29455), with histologically normal but relatively large kidneys containing a correspondingly large number of nephrons, died suddenly from an injury. Renal lobation was studied partly from serial transverse cuts across the kidney. The fibromuscular pelvic conduits, which are a craniocaudal bifurcation of the ureter, are associated with prominent longitudinally disposed paraconduital veins which anastomose with the interlobar veins. The arcuate veins open widely into the paraconduital veins. The latter drain into the major tributaries of the renal vein at the renal sinus. The interlobar arteries enter the parenchyma through the interlobar septa. These arteries release internal perforator branches, through the septa, which pass to the corticomedullary border, branch along that border as arcuate arteries, and release cortical branches centrifugally. All these branches give off twigs to the glomeruli. Relative renal mass of mammals is inversely proportional to their adult body mass. This is indicated by a regression line which includes rhinoceroses. D. bicornis No. 29455, accordingly, has exceptionally large kidneys. The mesonephros of the 75 mm fetus of D. bicornis has mature glomeruli and tubules. The metanephros has pelvic conduits, paraconduital veins, but, as yet, no medullary loops.
Anat Rec 1994 Jan
PMID:Further studies on the kidney of the hook-lipped African rhinoceros, Diceros bicornis. 811 90

Contrast radiography followed by ultrasonography of the urinary bladder was performed on 10 incontinent dogs. The ureterovesicular junctions and ureteral jets were identified by ultrasonography in all the dogs except one that had a caudally displaced bladder. An ectopic ureter in one dog was diagnosed by ultrasonography on the basis of the absence of a ureteral jet on the affected side, and the direct identification of the ureter passing caudal to the bladder neck. Ultrasonography appears to be a simple, repeatable test for identifying the distal ureters.
Vet Rec 1994 Jan 08
PMID:Ultrasonography of the ureterovesicular junction in the dog: a preliminary report. 813 5

A seven-month-old male alpaca (Lama pacos) with signs of abdominal straining was examined. A fluid-filled structure was palpable in the mid-abdominal region, and ultrasonography revealed a hydronephrosis of the right kidney, with an associated mega-ureter. The affected kidney was removed and the clinical signs resolved. Histological examination of the kidney revealed the unusual congenital abnormality of ureteral duplication. It is suggested that the hydronephrosis developed as a result of this underlying condition.
Vet Rec 1999 Jul 24
PMID:Hydronephrosis and ureteral duplication in a young alpaca. 1046 35

By exposing rat fetuses to adriamycin prenatally, a rat model of VATER association has been created. Absence of the fetal bladder is prominent and the kidneys show features of chronic obstruction with hydronephrosis/hydroureter, loss of parenchyma, fewer glomeruli, and less differentiation. The aim of this study was to elucidate this rat model, to determine exactly when the changes in the kidneys develop, hopefully thereby to expand our understanding of congenital obstructive uropathy. Timed-pregnant Sprague-Dawley rats were injected intraperitoneally with adriamycin on days 6-9 of gestation. The control group received saline. Fetuses were recovered on gestational days (GDs) 20, 19, 18, 17, 16, 15, 14, 12, and 10 (total, 120 control, 121 treated). Macroscopic features were determined. Serial sections were then taken and stained with hematoxylin and eosin. Comparisons were made under light microscopy. The metanephric kidney first became apparent at GD12. The development of the control and treated kidneys appeared similar till GD18. Beyond this day, the treated kidneys exhibited increasing degrees of distension of Bowman's capsule, ducts, and subsequently pelvis and ureter. There were fewer levels of glomeruli, which were also less differentiated. Less differentiation was also noted in the medulla, and with time this became thin in comparison to the control kidneys. By GD20, the renal pelvis was grossly dilated with a blunted papilla, and the renal parenchyma was thin. Prenatal exposure of rat fetuses to adriamycin results in kidneys that are chronically obstructed, as the majority of the fetuses show absence of the bladder. Absence of renal dysmorphology until GD18, when urine is first produced, suggests strongly that the effect of adriamycin on the kidney is indirect, via agenesis of the bladder and secondary to backpressure from early urine production. This is a unique, simple, and reliable model of fetal obstructive uropathy and will be very useful to facilitate further investigation into its pathophysiology and to explore new treatment options.
Anat Rec A Discov Mol Cell Evol Biol 2004 Jun
PMID:Ontogeny of the VATER kidney in a rat model. 1516 39

Thorough dehydration is a key for good plastination and invariably it leads to shrinkage. Shrinkage during plastination has been studied to lesser extent. Shrinkage was studied in 10 pig kidneys including regional shrinkage (cortex, medulla, sinus) and at which stages of the process (dehydration, impregnation, curing) shrinkage occurred. Kidneys were fixation by perfusion of 10% neutral buffered formalin solution via the renal artery. The vessels and ureter were filled with colored silicone (Dow Corning, Silastic E RTV Silicone Rubber) and the kidneys were cut into one centimeter transverse slices. Two slices of each kidney were plastinated via the classic von Hagens' method. Slices were photographed at the same focal length after preparation and at the end of each stage of plastination. Slice surface area was determined by a point-counting planimetry method. Post dehydration shrinkage of the kidney was 10.21% while post impregnation 10.11%. After completion of plastination, total area of kidney slice shrinkage was 19.72%. Cortical area shrunk 12.81% after dehydration and 13.16% after impregnation. After plastination, cortical area had shrunk 24.28%. No significant shrinkage occurred in the medulla and sinus. Results demonstrate that kidney shrinkage during impregnation is as intense as during dehydration. Significant shrinkage occurred in the renal cortex but not in the medulla and sinus. This demonstrates that different tissue types, even in the same specimen, have different rates of shrinkage during dehydration and impregnation. Therefore, plastinated specimens should be used carefully in research where obtaining measures is important.
Anat Rec (Hoboken) 2011 Aug
PMID:Shrinkage of renal tissue after impregnation via the cold Biodur plastination technique. 2171 12


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