Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0393754 (
HSA
)
2,996
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Heat-stable antigen (
HSA
/mouse CD24) is expressed in both haematopoietic and neural cells. The small core protein of the molecule is extensively glycosylated and anchored to the membrane via glycosylphosphatidylinositol. The role of
HSA
in the developing brain as well as its functional properties are poorly understood. Here we show that the brain
HSA
is associated with N- and O-linked oligosaccharide moieties and decorated with the
HNK-1
sulfated carbohydrate epitope. It can bind P-selectin but not E-selectin and this interaction requires divalent cations and is sensitive to high salt. Brain derived
HSA
is also capable of binding to the L1 adhesion molecule. This interaction is distinct from the P-selectin binding as it is resistant to high salt and does not require bivalent cations. Treatment of
HSA
with OSGE significantly reduced binding of both P-selectin and I.1. Our data suggest that
HSA
can bind P-selectin and I.1 by distinct mechanism and that the binding epitopes on
HSA
are in close proximity.
...
PMID:Heat-stable antigen (mouse CD24) in the brain: dual but distinct interaction with P-selectin and L1. 904 6
