Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0393754 (
HSA
)
2,996
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The incorporation of a polyoxometalate, octamolybdate (TBA
4
Mo
8
O
26
), into a metal-organic framework, mesoporous chromium terephthalate
MIL
-101(Cr), produces a novel hybrid Mo
8
O
26
@MIL-101(Cr). The covalent interactions of the Mo
8
O
26
moiety in the hybrid with the N-terminal site and the multi-metal binding site of proteins offer Mo
8
O
26
@MIL-101(Cr) favorable adsorption performance towards histidine-rich proteins, giving rise to adsorption capacities of 785.6 mg g
-1
for
HSA
and 420.1 mg g
-1
for IgG at pH 5.0. Thus, a protocol for the depletion of high abundance proteins from human plasma is proposed. The percentages of serum albumin and IgG are reduced from 50.15% and 13.18% to 7.41% and 3.42%, respectively. Meanwhile, low abundance proteins, e.g., Ig heavy chains, rheumatoid factors, protein IGKV3-11, anti-H1N1 influenza HA, and cDNA FLJ53691, are enriched to a certain extent by ultra-filtration. After the depletion of high abundance proteins, 335 protein species are identified in human plasma, with respect to 265 identified from the raw plasma. This illustrates well the potential of Mo
8
O
26
@MIL-101(Cr) in the application of proteomic studies.
...
PMID:An octamolybdate-metal organic framework hybrid for the efficient adsorption of histidine-rich proteins. 3226 75
