Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0393754 (HSA)
 2,996 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The usefulness of 99Tcm hydroxyethyl starch (99Tcm HES) has been evaluated for visualization of lymphatic channels and lymph nodes. 99Tcm HES was prepared with a labelling efficiency higher than 95%. Its usefulness for imaging lymphatic channels and lymph nodes were compared to 99Tcm human serum albumin (99Tcm HSA), 99Tcm dextran (99Tcm DXT) and 99Tcm sulphur micro colloid (99Tcm SMC) in rabbits. 99Tcm HES showed a good visualization of lymphatic channels and lymph nodes and it had the highest clearance rate from the injection site (P less than 0.01). 99Tcm HES showed higher uptake by the nodes than 99Tcm DXT (P less than 0.001) at 90 min post injection. The concentration of 99Tcm HES in the lymphatic channels was higher than that of 99Tcm SMC at 90 min post injection (P less than 0.001). Preliminary studies of 99Tcm HES in humans provided high-quality lymphoscintigrams of the leg, and the pelvic and para aortic lymph nodes in less than 10 min post injection. In addition, partially and completely obstructed lymphatics could be differentiated from the normal one. Hence 99Tcm HES is a potential radiopharmaceutical for visualization of lymphatic channels and nodes.
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PMID:99Tcm hydroxyethyl starch: a potential radiopharmaceutical for lymphoscintigraphy. 244 39

Tc-99m hydroxyethyl starch (Tc-99m HES) prepared with a labeling efficiency greater than 95% was evaluated in rabbits for visualization of lymphatic channels and lymph nodes, and the findings compared with Tc-99m human serum albumin (Tc-99m HSA), Tc-99m dextran (Tc-99m DXT), and Tc-99m sulfur microcolloid (Tc-99m SMC). Tc-99m HES showed good visualization of lymphatic channels and regional nodes and it had the highest clearance rate from the injection site (p less than 0.01). Tc-99m HES showed greater uptake by the nodes than Tc-99m DXT (p less than 0.001) at 90 minutes post-injection. The concentration of Tc-99m HES in the lymphatic channels was higher than that of Tc-99m SMC at 90 minutes post-injection (p less than 0.001). Preliminary clinical studies of Tc-99m HES yielded high quality lymphoscintigrams of the leg, and the pelvic and para-aortic lymph nodes in less than 10 minutes post-injection. In addition, partially and completed obstructed lymphatics could be differentiated from normal lymphatic pathways. In conclusion, Tc-99m HES is a promising radiopharmaceutical for imaging of lymphatic channels and nodes.
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PMID:Preparation and evaluation of Tc-99m hydroxyethyl starch as a potential radiopharmaceutical for lymphoscintigraphy: comparison with Tc-99m human serum albumin, Tc-99m dextran, and Tc-99m sulfur microcolloid. 248 39