Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0393754 (HSA)
 2,996 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The anti-DNP response to DNP-BGG is substantially suppressed in guinea pigs sensitized to DNCB. The degree of antibody suppression varies with the mode of skin sensitization and with the degree of conjugation of the challenging immunogen. Suppression of the anti-HSA response was also induced by the prior injection of CFA.
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PMID:Suppression of antibody synthesis to dinitrophenylated bovine gamma globulin in contact-sensitized guinea pigs. 114 54

Thirteen guinea pigs were immunized with TDI-BSA conjugates employing CFA or AHG adjuvant or only adjuvant as a control via intraperitoneal route. After 5-8 weeks, 30.8% of the sensitized animals experienced asthma attacks after a TDI-HSA challenge. The dynamic airway pulmonary ventilation imaging with Tc-99m-DTPA showed an accumulation of radioactivity. The radioactivity ratio of trachea or bronchus/lung was increased 6.46-29 times in contrast with before challenge. A specific IgE and IgG type antibodies were developed in 87.5% of TDI-BSA/CFA sensitized animals and 40% of TDI-BSA/AHG sensitized animals by passive cutaneous anaphylaxis (PCA). Results of these suggested that allergic response play an important role in the mechanism of TDI-induced asthma.
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PMID:[An experimental etiological study of toluene diisocyanate (TDI) induced occupational asthma]. 166 62

Two platinum (Pt) refinery workers with work related asthma was reported. The serum specific IgE and skin test for Pt antigen were positive. Ten guinea pigs were immunized with Pt-BSA conjugates employing CFA or AHG adjuvant via intraperitoneal. After 5-8 weeks, 33.3% of the sensitized animals experienced asthma attacks after a Pt-HSA challenge. The dynamic ventilation pulmonary imaging with 99mTc-DTPA showed a central accumulation of radioactivity. A specific IgE and IgG type antibodies were developed in 66.7% of sensitized animals by PCA test. Results of these suggested that platinum complex salt have antigenic specify. Allergic response play an important role in the mechanism of Pt induced asthma.
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PMID:[A study on the immunology and etiology of platinum induced asthma]. 181 74

Antigen-mediated stimulation of thymidine incorporation was demonstrated in lymph node cells from guinea pigs immunized with 100 microg human serum albumin in either Freund's incomplete or Freund's complete adjuvant. Animals receiving HSA in IFA exhibited both cutaneous basophil (Jones-Mote) hypersensitivity and lymphocyte stimulation at 1, but not at 6 wk after immunization. Significant stimulation required >/= 10 microg HSA/ml of culture. Sensitization with HSA in CFA produced delayed hypersensitivity and permitted lymphocyte stimulation at both 1 and 6 wk. Stimulation was observed with as little as 0.1 microg HSA/ml at the later interval. Administration of 5 mg HSA intravenously at the time of sensitization with 100 microg HSA in IFA reduced but did not eliminate both CBH and lymphocyte stimulation at 1 wk. Antigen-specific inhibition of macrophage migration could be demonstrated with exudates from animals immunized with HSA in CFA, but not with HSA in IFA at 3 wk after sensitization. HSA was cleared from depots of CFA and IFA at similar rates, but significantly more antigen appeared in the plasma and subsequently in the draining lymph nodes following administration in IFA. Conversely, accumulated antigen disappeared more rapidly following CFA immunization.
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PMID:Heterogeneity of the cellular immune response. II. The role of adjuvant, lymphocyte stimulation in cutaneous basophil hypersensitivity. 531 62

Mutations in the gene for gamma-sarcoglycan (SGCG) located on HSA 13q12 are responsible for limb girdle muscular dystrophy (LGMD2C) in human. Here we report the cloning of the canine SGCG gene together with its genomic structure and several intragenic polymorphisms. The coding part of the canine SGCG contains seven exons spanning at least 70 kb of genomic DNA. The chromosome assignment of the canine SGCG gene to CFA 25q21-->q23 confirms that the canine syntenic group 10 corresponds to CFA 25 and also supports the findings of human-canine reciprocal chromosome painting.
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PMID:Characterization and chromosome assignment of the canine gamma-sarcoglycan gene (SGCG) to CFA 25q21-->q23. 1185 78

Besides man, the dog is the only known mammalian species that spontaneously develops carcinomas of the prostate with considerable frequency. For this reason, the dog is considered to be the only useful animal model for spontaneously occurring prostate malignancies in man. Cytogenetic investigations of human prostate cancers have revealed the frequent occurrence of trisomies 7, 8, and 17. Chromosome analyses of canine prostate carcinomas are rare. In this report we present 2 cases of canine prostate cancer showing a clonal polysomy 13 along with complex karyotype changes. Along with a previous report demonstrating polysomy 13 as the only karyotype deviation in a canine prostate cancer the present report supports the hypothesis that in canine prostate cancer, polysomy 13 is a recurrent cytogenetic aberration linked to the development of the disease. As human chromosomes (HSA) 8q and 4q and the canine chromosome (CFA) 13 share high homology, these results suggest that a conserved area on these chromosomes is involved in tumorigenesis in both species.
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PMID:Two new cases of polysomy 13 in canine prostate cancer. 2066 68

For human tumours there are many reports documenting the correlation between chromosome aberrations and tumour entities. Due to the complex canine karyotypic pattern (78 chromosomes), cytogenetic studies of tumours of the dog are rare. However, the reports in the literature show, that canine chromosome 13 (CFA13) is predominantly involved in chromosomal changes. Interestingly, CFA 13 shows high homology to regions on the human chromosomes 4 (HSA 4) and 8 (HSA 8), which harbour the proto-oncogenes c-KIT and c-MYC . Both of these genes are involved in the development and progression of some human and canine tumour diseases.
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PMID:Relevance of chromosome 13 aberrations in canine tumours. 2291 Dec 58