Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0392680 (shortness of breath)
 5,217 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Synovial sarcoma accounts for 5-14% of all soft tissue tumours. We present a case of 35 year-old male who presented with five months history of progressively increasing shortness of breath and cough. On evaluation, there was no air entry on the left side. CAT scan chest showed a large necrotic mass involving the entire left hemi-thorax. The tru-cut biopsy of this mass was done and it showed synovial sarcoma. The entire tumour along with the lung and the pericardium was removed completely. The patient had an uneventful recovery and was discharged home in 10 days with follow-up for adjuvant chemotherapy. Due to the rarity of this disease, no guidelines for the treatment are available. Main existing treatment includes surgery followed by either radiation, chemotherapy or both. Synovial sarcoma should be considered in the differentials of an adolescent or adult male patient presenting with a mass in the thorax.
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PMID:Synovial sarcoma of the lung presenting late with compression of mediastinal structures and its successful resection: A case report. 2069 16

Calcified amorphous tumor of the heart (cardiac CAT) is a rare non-neoplastic cardiac mass that mimics malignancy on imaging and can cause symptoms due to flow obstruction or embolization of calcific fragments. We report a 57-year-old female with multiple medical problems affected by cardiac CAT. The echocardiogram showed a 2 x 1.7 cm right atrial mass. Under the clinical diagnosis of cardiac myxoma, a mass resection was performed. Microscopic examination of the resected mass showed nodular calcified amorphous debris with admixed degenerated fibrin and focal chronic inflammation. At the 1-year follow-up, the patient was free of disease. We performed a literature review of 16 previously reported cases. Histologically, a cardiac CAT consists of calcification and eosinophilic amorphous material in the background of dense collagenous fibrous tissue. A review of these cases shows a wide range of age at diagnosis and slight female predominance. The patients are either asymptomatic at presentation or complain of shortness of breath. The tumors have been found in all chambers of the heart, most commonly in the left ventricle. The sizes of the tumors range from 0.17 to 4 cm, with 62.5% of the tumors being mobile. Among the nine cases with documented follow-up study, all but one was free of disease and only one case of relapse was recorded. In conclusion, cardiac CATs are frequently asymptomatic at presentation, size is equal to or less than 4 cm, they can be located in all four chambers and are usually mobile, and they may relapse when not completely excised.
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PMID:Calcified amorphous tumor of the heart: case report and review of the literature. 2493 62