Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0392680 (shortness of breath)
 5,217 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four patients had acute dyspnea and chest pain due to primary neurologic disease, not to cardiac or pulmonary disorders. They suffered from severe, involuntary respiratory dyskinesias, which resulted in an irregular respiratory rate, shortness of breath, and chest discomfort. These respiratory dyskinesias occurred as one aspect of more generalized choreiform movement disorders. Three patients had neuroleptic-induced tardive dyskinesias, and one had levodopa-induced dyskinesias. As a result of their ages and the nature of their complaints, some of these patients were originally thought to have cardiac and pulmonary disorders. Respiratory dyskinesias should be considered as a possible cause of respiratory distress in patients with extrapyramidal dysfunction.
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PMID:Respiratory dyskinesias: extrapyramidal dysfunction and dyspnea. 62 94

A farmer who had no prior history of pulmonary disease developed tightness in the chest of rapid onset, shortness of breath, fever, and pulmonary infiltration while farming. The symptoms of his disease worsened with repeated exposure to the dusty farm field but remitted after each of five hospitalizations. Provocative challenge with inhalation of a water-soluble extract of dust from the field reproduced both asthmatic and pneumonitic features of the disease, while administration of corticosteroids clinically controlled the entire process. The data suggest a common cause for asthma and pneumonitis in this patient.
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PMID:Hypersensitivity pneumonitis and extrinsic asthma. An unusual association. 66 46

There are many causes for acute shortness of breath; the most common entity by far is congestive heart failure. Many of the others have a relatively specific radiographic pattern that afford the radiologist the opportunity to make a significant contribution to the care of these patients.
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PMID:Shortness of breath in emergency room patients. 68 3

Thirty-six patients with diffuse malignant pleural mesothelioma were seen over a period of 15 years. The median age was 60 years (range, 21 to 75 years), and the male to female ratio was 2.3 to 1. The most common symptoms were chest pain and shortness of breath and all patients presented with pleural effusion on chest x-ray. The diagnosis was established by tissue biopsy in all cases. The median survival time for all patients was 12.5 months. Twenty-one patients were treated with an adriamycin-containing regimen and in this group, the median survival time from histological diagnosis was 14 months. In contrast, the median survival time for the 15 patients, who did not receive adriamycin, was 6 months (p = 0.009). The median survival time from the initiation of chemotherapy was 9 months for the adriamycin group and 2 months for patients treated with other type of chemotherapy (p = 0.001). Adriamycin appears to be of benefit in the treatment of diffuse malignant pleural mesothelioma.
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PMID:The value of adriamycin in the treatment of diffuse malignant pleural mesothelioma. 70 31

Left ventricular function, as measured by systolic time intervals, was studied in 30 subjects with the syndrome of midsystolic click and late systolic murmur (ages, 20 to 53 years; mean, 34 +/- 9 years). Twenty-one were asymptomatic, six had chest pain, two had palpitations, one had shortness of breath, and one had hypotensive episodes. Each patient had the typical auscultatory and echocardiographic findings of the syndrome of midsystolic click and late systolic murmur. In the study the values for the interval between the onset of the QRS complex (Q) and the aortic component of the second heart sound (A2) (377 +/- 42 msec), the Q-A2 index (532 +/- 39 msec), the preejection period (PEP) (97 +/- 17 MSEC), THE PEP index (127 +/- 16 msec), the left ventricular ejection time index (403 +/- 26 msec) and the ratio of PEP to left ventricular ejection time (0.35 +/- 0.01) were not significantly different from the values in 17 controls matched for age. Out study, then, supports the contention that left ventricular function remains well preserved in most patients with the syndrome of midsystolic click and late systolic murmur.
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PMID:Systolic time intervals in the syndrome of midsystolic click and late systolic murmur. 83 May 3

During the winter months 1974/75 we were able to observe a number of unusual respiratory tract infections particularly in children over 6 years of age which appeared as pneumonias. Characteristic clinical findings included a dry, hacky cough, refractive to the usual antitussives, starting 1--2 weeks prior to admission, fever up to 104, malaise, headache, anorexia, shortness of breath and cyanosis. Several Pts were treated prior to admission with a number of antibiotics and failed to respond. Laboratory findings showed a peripheral polymorphonuclear leucocytosis with toxic granulations of neutrophiles. A sedimentation rate above 40 in the first hour occurred in most Pts. X Ray of the lung revealed a characteristic mottled appearance with patchy infiltrations, atelectasis and nodular densities. Frequently a shift of the mediastinum towards the infiltrate was seen. One of the hallmarks on physical examination was the discrepancy between the severity of the clinical illness and the paucity of physical findings. Decreased breath sounds over affected lung areas were often the only findings on auscultation; find rales, rhonchi or dullness on percussion were less often heard. The combination of a typical history, physical examination, laboratory tests and X Ray findings enabled us to make a presumptive clinical diagnosis of Mycoplasma pneumonia before serologic test results were available and to start with the appropriate antibiotic (Erythromycin, Tetracycline) early in the course of the disease. Complement fixation tests with a titer of 1 : 20 and a fourfold rise over the next two weeks or an initial titer of 1 : 80 and above were considered significant for acute disease.
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PMID:[Mycoplasma pneumonias in childhood (author's transl)]. 83 54

Children with obstruction mainly due to spasms of bronchial smooth muscle will benefit most from breathing exercises. Attainment of the individual physiological balance of muscular, nervous and psychogenic tensions--the eutonic tension--is of great importance for control of regular unhurried breathing. This will be supported by stimulation of nasal breathing which increases diaphragmatic excursion. The eutonic state is the fundamental basis for success of chest rotations and rhythmic movements to stimulate further relaxation. Awareness of the fact that breaths come by themselves -- "automatically" -- reduces anxiety of shortness of breath. Observations of a group of asthmatic children in a summer camp support this form of treatment of asthma.
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PMID:[Respiratory therapy in childhood asthma. Part 2. Eutonic training]. 83 62

An 18-year-old woman with stage IIIB Hodgkin's disease presented with minimal shortness of breath and progressed to fatal pulmonary insufficiency in five days. Biopsy and necropsy lung tissue specimens established the diagnosis of acute radiation pneumonitis. The diagnosis of radiation pneumonitis should be considered in the presence of a nonproductive cough, dyspnea, mixed interstitial and alveolar infiltrates on chest roentgenogram, negative cultures, and the characteristic findings on lung biopsy of macrophage accumulation and alveolar fibrin deposition in the face of minimal cellular infiltrate. A trial of steroid treatment may be warranted.
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PMID:Acute febrile illness associated with bilateral pulmonary infiltrates after irradiation in a patient with Hodgkin's disease. 84 87

There is an increased incidence of chronic disease in old age, and blood disorder is not uncommon. Some diseases are more frequent in the latter half of life, while others -- such as the hereditary disorders -- are rare and occur only in a mild degree. Diagnosis of blood disease is more difficult in the elderly because symptoms of anaemia such as weakness, shortness of breath and mental disorder are often attributed to old age.
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PMID:Blood diseases in old age. 85 40

A 47-yr-old woman, complaining of shortness of breath, had a chest X-ray showing a right parahilar mass and bronchoscopic examination disclosed a bluish flat lesion on the posterior wall of the trachea at the level of the fifth and sixth rings. Histological examination of the resected segment of trachea and an adjacent lymph-node revealed a primary tracheal melanoma with lymph-node metastasis. Review of five reported cases and of the literature on mucosal melanomas disclosed that the flat configuration of the tumour and the abundance of melanophages observed in the present case were unique. Possible relationships to mucosal melanosis and squamous metaplasia were briefly discussed.
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PMID:Primary "flat" melanoma of the trachea. 87 30


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