Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0392680 (shortness of breath)
 5,217 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Introduction Iliocaval thrombosis or thrombosis of the inferior vena cava (IVC) is associated with significant morbidity in the form of venous limb-threatening compromise. Patients often present with life-limiting occlusive symptoms secondary to recurrent lower extremity deep venous thrombosis, swelling, pain, venous stasis ulcers, or phlegmasia. Materials and Methods A retrospective analysis, between January 2018 and September 2020, of all patients suffering chronic iliocaval or IVC thrombosis and submitted to endovascular reconstruction were taken into consideration. Background, patient selection and indications, timing of intervention, procedural steps, technical considerations, postprocedural care and outcomes were registered. Additionally, a systematic review of the published literature between 2015 and 2020 searching MEDLINE/PubMed was performed. All published case series, case reports, potential randomized controlled trials, prospective and retrospective comparative cohort studies, and case-control studies where used for the qualitative synthesis of the systematic review. Results During the mentioned period, the authors found five clinical cases, 4 men, with a mean age of 58 years. Symptoms included lower extremity swelling or pain (n = 2), ulcers (n = 1), phlegmasia (n = 1), shortness of breath (n = 1). Procedural technical success with venous recanalization was achieved in 100% with every patient presenting clinical improvement. One patient suffered a major complication, with acute renal failure. At a mean follow-up of 13.8 months, three, six and twelve- -month, primary iliocaval stent patency rates were 100%, 100%, and 75%, respectively. From the systematic review, a total of 804 potentially eligible articles published were identified from literature searches. After screening on eligible criteria, 12 were selected for full- -text review, describing 56 patients. Overall technical success was 93% with a 96% clinical improvement and a primary patency rate at 12 months of 87%. Conclusions Endovascular iliocaval reconstruction is an effective treatment for iliocaval thrombosis with high levels of technical success, favourable clinical outcomes and stent patency rates, and few complications.
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PMID:Iliocaval Endovascular Reconstruction - Clinical Cases Presentation And Systematic Review Publication. 3328 Mar 14