Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0392674 (exhaustion)
 13,658 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 866
CD8 765
PD-1 441
CD4 429
cytokine 401
insulin 386
ATP 279
Mol 256
IFN 224
PD-L1 217
hemoglobin 153
lymphoid 145
interferon 138
CO2 135
TNF 126
IL-2 113
IL-10 108
Tim-3 107
ANOVA 103
LAG-3 99
CD28 98
CTLA-4 81
IL-6 79
TCR 78
creatine kinase 77
PD1 75
superoxide dismutase 73
ADP 71
mucin 70
growth hormone 69
TIM-3 69
GSH 64
p53 62
T cell receptor 61
glucagon 61
gut 61
thymus 60
lactate dehydrogenase 58
RPE 56
citrate synthase 55
ATPase 54
renin 53
tumor necrosis factor 53
catalase 53
mTOR 52
perforin 51
Mot 48
ACTH 46
reserved 46
interleukin-6 46
beta-endorphin 46
T-bet 45
TIGIT 44
NADH 44
albumin 43
granzyme B 43
MHC 43
APA 43
IFN-gamma 43
prolactin 42
glutathione peroxidase 42
CD57 41
NAD 41
cage 40
endoplasmic reticulum 40
HLA 39
CD27 38
CD19 38
Pol 38
programmed cell death 1 37
SARS 37
C-reactive protein 37
4-1BB 36
NMR 35
fibrinogen 35
Gen 35
Pseudomonas 35
HLA-DR 35
AMP 34
NK1 34
CD38 34
CD25 33
sit 33
granulocyte 33
CAR 32
IL-15 31
lipopolysaccharide 31
interleukin-2 31
PLA 31
collagen 31
CD127 30
PD-L2 30
erythroid 30
p21 30
ferritin 29
Men 29
IL-4 29
2B4 29
chemokine 28
Bcl-2 27
programmed death ligand 1 27
erythropoietin 26
She 26
KLRG1 26
CD69 26
myoglobin 25
phosphofructokinase 25
CD34 25
AKT 25
SOD 24
Cytokine 24
CD40L 24
CD20 24
vasopressin 24
histone 23
SIV 23
CD62L 22
CD40 22
anonymous 22
PGC 22
CD11b 22
IgA 22
TNF-alpha 22
IL-8 21
IL-1 21
myosin 21
pyruvate dehydrogenase 21
p38 21
Ki-67 21
MAPK 21
type I interferon 21
glycoprotein 21
NADPH 20
RER 20
major histocompatibility complex 20
tumor necrosis factor alpha 20
ICD 20
IL-21 20
caspase-3 20
CD39 20
cytochrome 20
PI3K 20
MHC class I 20
mover 19
glutathione reductase 19
thrombin 19
AMP-activated protein kinase 19
antioxidant enzyme 19
AMPK 18
interferon gamma 18
5-hydroxytryptamine 18
IL2 18
IL-7 18
cytochrome c 18
Fas 18
CD56 17
angiotensin II 17
aspartate aminotransferase 17
IL-17 17
amylase 17
more...
Disease
cancer 962
tumor 794
depersonalization 458
depression 417
HIV 348
stroke 263
diabetes 219
virus infection 197
cold 158
immunodeficiency 133
lymphocytic choriomeningitis 119
AIDS 118
hypertension 110
obesity 104
SEM 103
leukemia 101
tumor growth 95
dehydration 94
melanoma 92
hepatitis C 89
type 2 diabetes 87
anemia 86
heart failure 85
chronic obstructive pulmonary disease 85
ischemia 85
infectious diseases 83
myocardial infarction 73
hypoglycemia 70
hyperglycemia 69
sepsis 67
hepatitis B 67
viremia 65
GSH 64
cardiovascular disease 64
sepsis 63
hepatocellular carcinoma 58
cytomegalovirus 56
tuberculosis 54
Alzheimer's disease 54
tumor progression 54
chronic hepatitis 53
immunopathology 52
breast cancer 51
lymphoma 51
chronic fatigue syndrome 47
influenza 47
asthma 46
coronary heart disease 46
lung cancer 45
dementia 45
cirrhosis 45
mental illness 44
cognitive impairment 44
SARS 44
coronary artery disease 44
psychological distress 44
multiple sclerosis 42
metastases 41
type 1 diabetes 41
atherosclerosis 40
brucellosis 40
Mycobacterium 39
malnutrition 39
chronic lymphocytic leukemia 38
Blocking 38
hyperinsulinemia 37
myocardial ischemia 37
NAME 36
tumorigenesis 35
neuroticism 34
aggression 34
malaria 34
psychological stress 34
carcinoma 33
acute myeloid leukemia 33
Duchenne muscular dystrophy 33
suicide 33
violence 33
Hodgkin's disease 31
multiple myeloma 31
heart disease 30
colorectal cancer 29
fits 29
confusion 28
hematologic malignancies 28
chronic disease 28
Epstein 28
posttraumatic stress disorder 28
non-small cell lung cancer 27
chronic lymphocytic leukemia 27
sleep disturbances 27
family conflict 26
Leukemia 26
lactic acidosis 26
metabolic syndrome 25
Syndrome 25
pneumonia 25
emotional stress 24
hepatitis 24
Infection 24
B-cell lymphoma 23
respiratory failure 23
cystic fibrosis 23
herpes simplex 23
Burnout syndrome 23
chronic pain 23
congestive heart failure 23
West 23
thrombocytopenia 22
renal disease 22
epilepsy 22
plaque 21
lymphopenia 21
psychosis 21
osteoporosis 21
alkalosis 20
sleep disorders 20
liver cancer 20
ICD 20
carcinogenesis 20
adenocarcinoma 20
rheumatoid arthritis 20
autoimmune disease 20
fibromyalgia 20
systemic lupus erythematosus 20
Parkinson's disease 20
renal failure 19
prostate cancer 19
squamous cell carcinoma 19
Beard 19
abortion 18
myelodysplastic syndrome 18
emotional distress 18
glioblastoma 18
graft-versus-host disease 17
metastatic melanoma 17
leishmaniasis 17
muscular atrophy 17
acute myocardial infarction 17
glioma 17
addiction 16
coma 16
ICC 16
lung disease 16
premature aging 16
ICC 16
renal cell carcinoma 16
anxiety disorders 16
mountain sickness 15
Chagas 15
Klebsiella 15
glucose intolerance 15
liver disease 15
schizophrenia 15
infertility 15
COPD 15
Fanconi 14
MRS 14
tetanus 14
myopathy 14
more...
Symptom
exhaustion 13658
fatigue 1281
pain 214
weakness 152
starvation 95
dyspnea 85
discomfort 66
discomfort 61
collapse 57
anesthesia 52
insomnia 50
headache 45
myalgia 42
hypothermia 41
seizures 37
nausea 35
angina 34
sleepiness 33
syncope 32
overweight 31
physical exhaustion 29
hyperoxia 27
anorexia 27
agitation 26
diarrhea 26
dizziness 24
hypercapnia 23
acute stress 22
mental fatigue 20
Ill 19
vomiting 16
cough 16
cachexia 15
analgesia 15
hopelessness 15
tremor 15
splenomegaly 15
respiratory distress 15
asthenia 13
hunger 13
arthralgia 13
stigma 12
hypocapnia 11
back pain 11
chest pain 11
tense 10
apathy 10
acidity 10
lethargy 9
menopausal symptoms 9
muscle cramps 9
Depressive symptoms 8
functional recovery 8
low back pain 8
spasticity 8
abdominal pain 8
constipation 8
flushing 8
colic 8
alexithymia 7
twitching 7
hot flushes 7
tachypnea 7
Muscle soreness 6
chills 6
shortness of breath 6
emaciation 6
excessive sweating 6
paresis 6
abdominal discomfort 6
memory loss 6
dystonia 5
despair 5
muscle rigidity 5
nausea and vomiting 5
Wind 5
Exercise intolerance 5
catatonia 5
exertional dyspnea 5
erythema 4
ketonuria 4
ataxia 4
paresthesia 4
sore throat 4
feeling exhausted 4
hepatomegaly 4
distraction 4
lightheadedness 4
tinnitus 4
Fluctuation 3
hypoproteinemia 3
leg pain 3
forgetfulness 3
abdominal cramps 3
exertional angina 3
feeling depressed 3
knee pain 3
pallor 3
dry skin 3
regurgitation 3
Plantar flexion 3
decreased appetite 3
hangover 3
giddiness 3
giddiness 3
shoulder pain 3
thinning 3
feeling tired 3
neck pain 3
hot flashes 3
cancer pain 2
Hemiballism 2
Poor sleep 2
BHS 2
disturbed balance 2
metatarsalgia 2
HSA 2
Anoxia 2
joint stiffness 2
hypertonia 2
Hudson 2
hypotonia 2
consciousness disturbance 2
fasciculation 2
neuralgia 2
bradykinesia 2
pedal edema 2
night sweats 2
numbness 2
generalized pain 2
ophthalmoplegia 2
epigastric pain 2
chronic cough 2
polyuria 2
hyperacusis 2
Noise-induced hearing loss 2
hypersomnia 2
breath holding 2
prostration 2
Mills 2
snoring 2
presyncope 2
stomach pain 2
Fatigability 2
hoarseness 2
partial seizure 1
Infantile colic 1
blurred vision 1
GI irritation 1
wheezing 1
non-productive cough 1
Scratch 1
intestinal bleeding 1
paraparesis 1
polydipsia 1
dysarthria 1
Sedation 1
photophobia 1
tingling 1
physical symptom 1
more...
Drug
IL-2 114
caffeine 100
NADH 44
IFN-gamma 40
Dermatol 27
CSF 24
Cardiovasc 24
lactose 21
vitamin E 20
ascorbate 19
lysine 18
ROS 17
NH3 17
Nephron 17
citric acid 15
MAP 13
Monit 12
PDL 11
Spectrum 11
Glutathione 10
Leaf 10
FAD 9
Glycerol 9
G-CSF 9
Ethanol 8
Alanine 8
Salbutamol 8
IL-1ra 8
Glucagon 8
CFS 7
Nephron 7
Vitamin E 6
nitroglycerin 6
Diurnal 6
ICI 6
Nitric Oxide 6
HCH 5
CaCl2 5
CaCl2 5
Dial 5
Albumin 5
Growth hormone 5
Captopril 5
CaCl2 5
Growth hormone 5
Posture 5
beta-Galactosidase 4
Check 4
VCR 4
Histamine 4
Ginseng 4
Atenolol 4
Gel 4
Inderal 4
Oxycon 4
Asthma 4
p75 3
Ouabain 3
ACT 3
niacin 3
Fructose 3
Ranitidine 3
Lactose 3
Angiotensin II 3
Bifidobacterium 3
Kenyan 3
PTH 3
Amiloride 3
THF 3
Galactose 3
Frontal 3
EPA 3
Sodasorb 2
IL-11 2
CTC 2
ETS 2
Portal 2
Lenalidomide 2
CCL 2
Modafinil 2
Atropine 2
Phentolamine 2
ZnO 2
PCB 2
Asn 2
DBS 2
MRC 2
ROC 2
Mestinon 2
Red ginseng 2
Clonidine 2
Viagra 2
Maltose 2
Pyridostigmine bromide 2
ADM 2
Paraffin 2
Lovastatin 2
CTC 2
Prednisone 2
Vitamin B12 2
Vitamin A 2
Rituximab 2
GEO 2
ALA 2
Timolol 2
Adenosine triphosphate 2
Calcium gluconate 1
Fenoterol 1
Sinemet 1
DEX 1
2-Methoxyestradiol 1
Idarubicin 1
ENT 1
Antithrombin III 1
NAG 1
CDP 1
Timoptol 1
Brevibloc 1
RSM 1
Bricanyl 1
EE2 1
PFA 1
Glybenclamide 1
Parkin 1
Zoledronic acid 1
Triad 1
BH4 1
Dakar 1
Bupivacaine 1
Velban 1
Diphenhydramine 1
Apomorphine 1
Horizon 1
NaI 1
Doxycycline 1
ZnCl2 1
OP-2 1
Phosphatidylserine 1
Parkin 1
Heme 1
Sandostatin 1
ADR 1
Fludarabine 1
Mofezolac 1
Glycyrrhiza 1
metformin hydrochloride 1
Ferrous sulfate 1
EPI 1
dibasic calcium phosphate 1
DHT 1
Citric acid 1
SPP 1
Bezafibrate 1
Longgu 1
CEC 1
Epoetin alfa 1
Enalaprilat 1
Dasatinib 1
Sodium acetate 1
Scopolamine 1
more...
Enzyme
creatine kinase 96
superoxide dismutase 95
lactate dehydrogenase 67
ATPase 66
catalase 58
citrate synthase 55
renin 53
ERK 48
glutathione peroxidase 44
mitogen-activated protein kinase 41
granzyme B 40
protein kinase 35
AMP-activated protein kinase 35
focal adhesion kinase 34
alanine aminotransferase 29
peroxidase 28
aspartate aminotransferase 28
phosphofructokinase 26
phosphorylase 25
pyruvate dehydrogenase 24
acetylcholinesterase 22
pyruvate dehydrogenase 20
cytochrome oxidase 20
pyruvate dehydrogenase 20
AMPK 20
thrombin 19
glutathione reductase 19
cholinesterase 18
AMPK 18
PRE 17
alkaline phosphatase 17
proteasome 17
succinate dehydrogenase 15
pyruvate kinase 15
hexokinase 15
caspase-3 15
ACE 15
APC 14
glucose-6-phosphate dehydrogenase 14
protein kinase C 14
trypsin 13
beta-galactosidase 13
isocitrate dehydrogenase 12
ACS 12
calcineurin 12
PARP 12
isocitrate dehydrogenase 11
kallikrein 11
aldehyde dehydrogenase 11
nitrogenase 10
carbonic anhydrase 10
reverse transcriptase 10
NADPH oxidase 10
3-hydroxyacyl-CoA dehydrogenase 10
phosphoenolpyruvate carboxykinase 10
lipase 9
malate dehydrogenase 9
NO synthase 9
RNA polymerase 9
phosphoenolpyruvate carboxykinase 9
phosphoenolpyruvate carboxykinase 9
luciferase 9
xanthine oxidase 9
lysozyme 9
CFI 9
3-hydroxyacyl-CoA dehydrogenase 8
NADPH oxidase 8
aldehyde dehydrogenase 8
glyceraldehyde-3-phosphate dehydrogenase 8
aldehyde dehydrogenase 8
tryptophan hydroxylase 8
aldehyde dehydrogenase 8
glutathione S-transferase 8
MAP 8
AST 8
PDK1 8
aldehyde dehydrogenase 8
ceruloplasmin 7
complex I 7
glyceraldehyde-3-phosphate dehydrogenase 7
MIP 7
phosphatidylinositol 3-kinase 7
glyceraldehyde-3-phosphate dehydrogenase 7
AMP deaminase 7
tissue plasminogen activator 7
thromboplastin 7
phosphodiesterase 7
adenylate cyclase 7
phospholipase C 7
BAL 6
glyceraldehyde-3-phosphate dehydrogenase 6
DNA methyltransferase 6
glutamine synthetase 6
aconitase 6
trehalase 6
invertase 6
MEK 6
glyceraldehyde-3-phosphate dehydrogenase 6
glutamate dehydrogenase 6
glutamate dehydrogenase 6
aldolase 6
glutamate dehydrogenase 6
adenosine deaminase 6
adenosine deaminase 6
CaMKII 6
caspase-1 6
lipoprotein lipase 5
elastase 5
acid phosphatase 5
cellulase 5
TOR 5
alcohol dehydrogenase 5
arginase 5
glycerol-3-phosphate dehydrogenase 5
tyrosinase 5
glucokinase 5
DNA polymerase 5
NOS 5
plasmin 5
monoamine oxidase 5
Pla 5
pyruvate carboxylase 5
alpha-glucosidase 5
phosphoinositide 3-kinase 5
glycerol-3-phosphate dehydrogenase 5
ribonucleotide reductase 4
ribonucleotide reductase 4
citrate lyase 4
5'-nucleotidase 4
diaphorase 4
STR 4
caspase-8 4
PDH 4
tyrosine hydroxylase 4
urokinase-type plasminogen activator 4
cdc2 4
indoleamine 2,3-dioxygenase 4
CD10 4
alpha-ketoglutarate dehydrogenase 4
glycogenin 4
nitrate reductase 3
nitrate reductase 3
ribonuclease 3
RNase 3
ribonuclease 3
RNase 3
nitrate reductase 3
NADH dehydrogenase 3
lipoxygenase 3
phospholipase A2 3
enolase 3
nucleotidase 3
NQO1 3
prostate-specific membrane antigen 3
glucose-6-phosphatase 3
beta-glucuronidase 3
gluconate dehydrogenase 3
PCE 3
demethylase 3
glucose oxidase 3
more...
Compound
oxygen 1884
glucose 968
Dec 907
water 588
Clin 477
DNA 348
ATP 280
CO2 268
calcium 220
phosphate 215
nitrogen 199
sodium 194
TNF 126
ammonia 120
glycerol 115
caffeine 100
iron 99
acetate 98
potassium 97
Cardiol 96
noradrenaline 94
nitrate 86
Lactate 85
phosphocreatine 83
ethanol 80
hydrogen 78
ADP 74
urea 72
ADP 71
ADP 71
GSH 69
GSH 69
nitric oxide 69
arginine 64
galactose 61
glutamine 54
ammonium 54
alanine 53
salt 52
glutamate 52
NAD 52
Insulin 50
phosphorus 48
ACTH 47
sulfate 46
tryptophan 45
NH2 45
NADH 44
Glycogen 44
creatinine 42
NAD 41
carbonate 41
tryptophan 40
aldosterone 40
copper 39
tryptophan 37
AMP 37
tyrosine 37
tryptophan 37
His 35
leucine 35
CoA 32
zinc 31
cyanide 31
methionine 31
cAMP 30
FFA 30
Cortisol 28
Mg2+ 25
MDA 25
Phe 25
nicotinamide 24
5-HT 23
threonine 23
acetic acid 23
Adrenal 23
lysine 23
manganese 22
silver 22
serine 22
2-oxoglutarate 21
NADPH 20
sodium chloride 20
chromium 20
cysteine 20
NADPH 20
PLA 19
SEE 19
cadmium 18
bromide 18
iodine 17
PEG 16
pentose 16
methanol 16
H2O2 16
GSSG 15
prostacyclin 15
DHA 15
xylose 15
hydroxide 14
PMA 14
proline 14
Propranolol 14
L-carnitine 14
HCO 14
adenylate 13
pentose 13
IMP 13
Nitrate 13
pentose 13
Lac 13
pentose 13
acetyl-CoA 13
N-acetylcysteine 13
hexose 13
aldehyde 13
HCl 12
PMA 12
valine 12
Dopamine 12
phosphoric acid 12
beta-alanine 12
Ile 12
L-DOPA 11
hexose 11
isoleucine 11
Norepinephrine 11
aldehyde 11
hexose 11
H2S 11
Optimal 11
NKT 11
hexose 11
ACS 11
ACS 11
NIDA 10
Propranolol 10
Estrogen 10
glucose-6-phosphate 10
SDS 10
EDTA 10
Taurine 10
aluminum 10
ubiquinone 10
MAP 10
EDTA 10
isoleucine 10
Asp 10
SO2 9
cobalt 9
Diabetol 9
selenium 9
asparagine 9
vitamin D 9
TCA 9
retinol 9
FAD 9
GABA 9
GABA 9
chloroform 9
more...