Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0392674 (
exhaustion
)
13,658
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aim:
To explore the biological functions and clinicopathologic significance of the long noncoding RNA
KTN1
-AS1
in head and neck squamous cell carcinoma (HNSCC).
Materials & methods:
We assessed the effects of
KTN1
-AS1
and identified the target miRNA by bioinformatics analysis, luciferase reporter, RNA pull-down and RNA immunoprecipitation assays. The clinicopathologic features of
KTN1
-AS1
and its target miRNA were analyzed in HNSCC.
Results:
KTN1
-AS1
, a competing endogenous RNA, promoted cell proliferation, migration, invasion and epithelial-mesenchymal transition by sponging
miR-153-3p
in HNSCC. Dysregulation of
SNAI1
and
ZEB2
mediated the effect of
KTN1
-AS1
due to
miR-153-3p
exhaustion
. The
KTN1
-AS1
and
miR-153-3p
combination can accurately diagnose HNSCC.
Conclusion:
The
KTN1
-AS1
and
miR-153-3p
combination could be a valuable diagnostic and prognostic predictor for HNSCC.
...
PMID:Long noncoding RNA
KTN1-AS1
promotes head and neck squamous cell carcinoma cell epithelial-mesenchymal transition by targeting
miR-153-3p
. 3226 61
