Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0392674 (exhaustion)
 13,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The nidi of hemopoiesis appeared in the liver and the lymph nodes of DBA/2, C57BL/6j and F1 (C57BL/6j X CBA) strains of mice of the 6th day after a single intraperitoneal injection of cyclophosphamide in a dose of 200 mg/kg. This process was accompanied by the appearance of stem hemopoietic cells in the liver. Their maximum number was observed on the 6th and the 9th days. On the 12th day their level decreased, but it still exceeded the one in the animals which received a suspension of normal liver cells. In myelosan exhaustion the pool of the bone marrow and splenic stem cells, the subsequent cyclophosphamide injection failed to induce the appearance of the nidi of hemopoiesis and stem cells in the liver.
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PMID:[Appearance of foci of hematopoiesis and hematopoietic stem cells in the liver of mice following a single administration of cyclophosphane]. 122 81

Complement-mediated mode of action of bisbenzylisoquinoline alkaloid fangchinoline was investigated in vivo and in vitro. The application of fangchinoline intraperitoneally (i.p.) to complement normal mice, strain ICR, inhibited the complement activity in serum and peritoneal exudate. The substance activated serum complement of C5-deficient DBA/2 mice. Fangchinoline was able to provoke local inflammatory reaction in both strains after subcutaneous (s.c.) injection. The alkaloid suppressed paw swelling induced by live Candida albicans in ICR and DBA/2 mice. Its effect depended on the dose and time of injection prior to inflammatory reaction. The in vitro experiments proved the interference of fangchinoline action with post-C5 reactions. The substance augmented C5-convertase formation and functional activity. These results are in correspondence with our previous investigations, proving the complement-mediated action of fangchinoline. The antiinflammatory effect could be a consequence of the caused complement exhaustion.
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PMID:Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline. 1196 44