Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0392674 (exhaustion)
 13,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this investigation was to study the effect of blood infusion upon maximal endurance capacity and ratings of perceived exertaion (RPE). Sixteen long-distance runners, 13 of whom were marathoners, undertook four trials (T1-T4) of a treadmill run to exhaustion over a five week period. Criterion measures were time to exhaustion (TE) and RPE during each T. Data on Hb, Hct and RBCs were collected prior to each trial. Based on TE at T1, Ss were matched and assigned to either the experimental (E) or control (C) group. One week after T1, all Ss had 460 ml blood withdrawn. T2 was undertaken 2 weeks postwithdrawal. One week after T2, or 21 days postwithdrawal, the E group was infused with their own RBCs while the C group received 460 ml normal saline. T3 was taken 2 hours postinfusion and T4 one week later. The results of the factorial repeated measures ANOVA revealed no significant differences (p less than .05) between groups for either TE or RPE, even though the Hb level for the E group was significantly higher (P less than .01) than the C group at T3 and T4.
 ...
PMID:The effect of blood infusion upon endurance capacity and ratings of perceived exertion. 69

A total of 14 healthy subjects [means (SD): 27.6 (3.8) years; body mass 77.8 (6.6) kg; height 183 (6) cm] performed endurance exercise to exhaustion at 100% of the individual anaerobic threshold (Th(an)) on a cycle ergometer (mean workload 207 (55) W; lactate concentrations 3.4 (1.2) mmol.l-1; duration 83.8 (22.2) min, including 5 min at 50% of individual Th(an)). Leucocyte subpopulations were measured by flow cytometry and catecholamines by radioimmunological methods. Blood samples were taken before and several times during exercise. Values were corrected for plasma volume changes and analysed using ANOVA for repeated measures. During the first 10 min of exercise, of all cell subpopulations the natural killer cells (CD3-CD16/CD56+) increased the most (229%). Also CD3+CD16/CD56+ (84%), CD8+CD45RO- (69%) cells, eosinophils (36%) and monocytes (62%) increased rapidly during that time. CD3+, CD3+HLA-DR+, CD4+CD45RO+, CD4+CD45RO-, CD8+CD45RO+ and CD19+ cells either did not increase or increased only slightly during exercise. Adrenaline and noradrenaline increased nearly linearly by 36% and 77% respectively at 10 min exercise. The increase of natural killer cells and heart rates between rest and 10 min of exercise correlated significantly (r = 0.576, P = 0.031). We conclude that natural killer cells, cytotoxic, non-MHC-restricted T-cells, monocytes and eosinophils are mobilized rapidly during the first minutes of endurance exercise. Both catecholamines and increased blood flow are likely to contribute this effect.
 ...
PMID:Differential mobilization of leucocyte and lymphocyte subpopulations into the circulation during endurance exercise. 148 41

We investigated whether fatigue of the expiratory muscle, that is, the abdominal muscle, may account for a change in the respiratory effort sensation in normal subjects during expiratory threshold loading. The respiratory effort sensation was scored using a modified Borg scale. Expiratory muscle fatigue was assessed both from changes in the maximal static expiratory pressure and in the centroid frequency (fc) of the abdominal muscle electromyogram (EMG). Expiratory threshold loading (magnitude of threshold; 40 to 60% of the maximal expiratory pressure at FRC, breathing frequency = 15/min, and duty cycle = 0.5) was continued until exhaustion or for 30 min. Loading was repeated following a 15-min recovery period after the end of the first expiratory loading. The maximal static expiratory pressure during loading (Pmmax) decreased initially and then remained decreased. Decreases were smaller with the 40% load (22 +/- 6%, SEM) than with the 60% load (37 +/- 3%) (p less than 0.05). The decrease during the second run of the 60% load was greater than during the first (p less than 0.01 by ANOVA). The maximal expiratory pressure at TLC before the second run of the 60% load was decreased by 9 +/- 3% compared with the control (p less than 0.02) but that with the 40% load was not. The fc with the 60% load decreased initially by 8 +/- 1% and then remained constant, although no change was observed with the 40% load.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Relationship of respiratory effort sensation to expiratory muscle fatigue during expiratory threshold loading. 173 58

The purpose of this investigation was to determine the effect of ambient temperature on the salivary immunoglobulin A (s-IgA) response to submaximal exercise. Nine adult males (x age +/- SD = 22 +/- 2 yrs) volunteered to perform an incremental treadmill test to exhaustion for the determination of VO2max and three 30-minute treadmill runs at 80% VO2max in an environmental chamber at temperatures of approximately 6, 19 and 34 degrees C. Saliva samples were collected prior to each submaximal workbout as well as immediately and 1 hr post-exercise. A 2 within subjects factors (temperature, sample time) repeated measures ANOVA indicated no significant interaction or main effects for sampling time or temperature. The results of this study indicated that 30 minutes of non-competitive exercise at temperatures ranging from 6 to 34 degrees C had no effect on s-IgA. These findings suggest that moderate intensity exercises at a wide range of ambient temperatures does not increase the susceptibility to upper respiratory infection by decreasing s-IgA.
 ...
PMID:The effect of exercise at various temperatures on salivary levels of immunoglobulin A. 175 20

The effects of different types of music on heart rate (HR), rating of perceived exertion (RPE), and time to exhaustion during treadmill work were determined on 24 volunteer college students (Ss). The Ss participated in three randomly assigned multistaged treadmill walk/run to exhaustion while wearing a head-set. The three treatments were: loud, fast, exciting, popular music (Type A); soft, slow, easy-listening, popular music (Type B); and no music (control). HR was recorded at 0:30 of each minute until voluntary exhaustion. RPE was obtained after the test for five different points during the test. Differences (p less than 0.10) among experimental treatments were determined by a one-way ANOVA and Newman-Keuls. HR was lower with Type B music in minutes one and six. The peak HR and the HR in the minute preceding max were higher with Type B music. Time to exhaustion was longer during the Type B music treatment than during the control treatment. RPE was lower for Type B music than control during moderate work. This study provided some support for the hypothesis that soft, slow music reduces physiological and psychological arousal during submaximal exercise and increases endurance performance.
 ...
PMID:Effects of types and intensities of background music on treadmill endurance. 186 74

It has been suggested in the lay literature that static stretching and/or warm-up will prevent the occurrence of Delayed-Onset Muscle Soreness (DOMS). The primary purpose of this study was to determine the effects of static stretching and/or warm-up on the level of pain associated with DOMS. Sixty-two healthy male and female volunteers were randomly assigned to four groups: (a) subjects who statically stretched the quadriceps muscle group before a step, (b) subjects who only performed a stepping warm-up, (c) subjects who both stretched and performed a stepping warm-up prior to a step test, and (d) subjects who only performed a step test. The step test (Asmussen, 1956) required subjects to do concentric work with their right leg and eccentric work with their left leg to voluntary exhaustion. Subjects rated their muscle soreness on a ratio scale from zero to six at 24-hour intervals for 5 days following the step test. A 4x2x2 ANOVA with repeated measures on legs and Duncan's New Multiple Range post-hoc test found no difference in peak muscle soreness among the groups doing the step test or for gender (p greater than .05). There was the expected significant difference in peak muscle soreness between eccentrically and concentrically worked legs, with the eccentrically worked leg experiencing greater muscle soreness. We concluded that static stretching and/or warm-up does not prevent DOMS resulting from exhaustive exercise.
 ...
PMID:The effects of static stretching and warm-up on prevention of delayed-onset muscle soreness. 248 63

The aim of the present investigation was to compare the changes in plasma estradiol (E2), progesterone (P), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), androstenedione (delta 4-A), dehydroepiandrosterone sulfate (DHEA-S), adrenocorticotropic hormone (ACTH), and prolactin (PRL) in standardized tests (15-min consecutive work loads of 60%, 70%, 80% VO2 max to exhaustion) in 13 eumenorrheic untrained (UT) and 8 highly trained women (MR). Blood was obtained 15 and 2 min before exercise and at the end of each work load or each 15 min period. The results showed a significant increase (0.05 greater than P less than 0.001, two-way ANOVA) in plasma E2 P, T delta 4-A, PRL, and ACTH both in UT and MR irrespective of the phase of the menstrual cycle. DHEA S levels increased significantly in the MR, but not in the UT, PRL and ACTH increased linearly with exercise in MR and nonlinearly in UT. In the latter group, only the 80% VO2 max work load was able to elicit significant increments in the plasma levels of these hormones. In the MR plasma T and delta 4-A levels increased relatively more pronounced (P less than 0.05) at comparable work loads and exercise times than in the UT. LH levels decreased with exercise both in the UT and MR, whereas FSH levels remained unchanged (MR) or decreased (UT). These findings suggest that during exercise the ovarian hormones are increased by more unspecific mechanisms such as a decreased metabolic clearance rate, whereas in the MR, adrenal secretion of androgens is enhanced.
 ...
PMID:Multiple hormonal responses to physical exercise in eumenorrheic trained and untrained women. 342 89

Nine male and five female college students were tested on four occasions to determine the effects of various exhaustive weightlifting stimuli on forearm blood flow as measured by strain-gauge plethysmography. Maximum voluntary dynamic wrist curl strength was determined in the first session, which was followed by random treatments of exercise with 70, 80, and 90% of the weight subjects could curl only one time (1 RM) on three separate days. During each treatment, after a 15-min rest, subjects performed three sets of exercise movements at a pace of 0.5 Hz until voluntary exhaustion. Each set of continuous repetitions was followed by a 166-s recovery period. Blood flows (ml flow X 100 ml tissue-1 X min-1) were determined at 10, 36, 62, 88, 114, 140, and 166 s of recovery. Data were analyzed using ANOVA tests for a three (intensities) by three (sets) complete factorial design with repeated measures on all factors. Generally, 90% flows were significantly (P less than 0.05) lower than both 70 and 80% flows. Also, 70% flows were statistically equal to 80% flows. There were significant (P less than 0.05) set effects at 10, 36, 114, and 166 s of recovery. Blood flows for set 3 exceeded those for set 1 at 10, 36, 114, and 166 s of recovery, and blood flows for set 2 exceeded those for set 1 at 166 s of recovery.
 ...
PMID:Adaptations of forearm circulation to varied intensities and sets of heavy exercise. 664 60

In a population sample of 'healthy' males (N = 136; age 39-41) the classifications on the Jenkins Activity Survey (JAS) for assessing the Type A/B coronary-prone behavior pattern, and on the Maastricht Questionnaire (MQ), measuring emotional drain and subsequent depression, were investigated in relation to retrospective reporting of life changes on a newly developed Middle Adulthood Life Changes Questionnaire (MALC). In ANOVA, Type A subjects (N = 70) did report significantly more life changes in their work environment and family situation over the last two years than their Type B counterparts (N = 66). For subjects reporting clearcut manifestations of vital exhaustion and depression (N = 32) the same statistical associations do hold. Also, these latter subjects did evaluate their life changes as significantly 'more distressing' or as 'requiring more adjustment'. A group of male myocardial infarction (MI) patients (N = 35; average age 52) was compared with this control group on the MQ and the MALC. The MI-group showed a significantly lower average MQ-score than the section of the control group with clearcut manifestations of emotional drain and depression. Mean 'adjustment' scores, however, were significantly higher in the MI-group. In the discussion, the requirements for a dynamic life-span developmental model for explaining the assumedly different life-courses of MI-cases and controls are enunciated.
 ...
PMID:[Life styles of myocardial infarct patients and of control groups: various similarities and differences]. 720 68

The influence of music on physiological and affective exercise responses was studied in 8 trained and 8 untrained runners under three music conditions ("no", "sedative", and "fast") during low, moderate, and high intensity exercise. Repeated measures ANOVA revealed increased respiratory frequency (FR) during fast music as compared to the no music and sedative music conditions (p < 0.01). Plasma cortisol levels did not differ at baseline across the music conditions; however, following high intensity exercise, higher cortisol levels were associated with fast music as compared to no music and sedative music (music x intensity interaction, p < 0.01). Affective measures during exercise (FEELING scale) showed no overall training group differences; however, there was a music x group x intensity interaction (p < 0.05) in which untrained subjects reported more positive affect compared to trained subjects while listening to fast music during low and high intensity exercise. Data collected at voluntary exhaustion revealed significantly more positive affect and higher skin temperature (p values < 0.01) in untrained compared to trained subjects. Collectively, these results suggest listening to fast, upbeat music during exercise may be beneficial for untrained runners but counterproductive for trained runners.
 ...
PMID:Effects of music on physiological and affective responses to graded treadmill exercise in trained and untrained runners. 755 86


1 2 3 4 5 6 7 8 9 10 Next >>