Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0392674 (exhaustion)
 13,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was carried out to investigate the importance of maximal oxygen uptake (VO2max) and so-called muscle power factors relating to neuromuscular and anaerobic characteristics as determinants of peak horizontal and uphill treadmill running velocity (Vmax). Muscle power factors were measured as peak velocity (VMART) and blood lactate concentration (BlaMART) in a maximal anaerobic running test and as maximal 30-m run velocity (V30m). Seven middle-distance runners, eight triathletes and eight cross-country skiers performed an incremental VO2max-test at horizontal (subscript max0) and 7 degrees uphill (subscript max7) and the MART at 3 degrees uphill on a treadmill and V30m-test on a track. The MART consisted of n x 20-s runs with a 100-s recovery between the runs and the velocity was increased by 0.41 m x s(-1) for each consecutive run until exhaustion. At 0 degrees Vmax was significantly higher but VO2max, ventilation and Bla were significantly lower than at 7 degrees inclination. Vmax0 correlated with VMART (r=0.85, P<0.001), Blamax0 (r=0.49, P<0.05) and V30m (r=0.78, P<0.001) but not with VO2max0. Vmax7 correlated with VO2max7 (r=0.78, P<0.001), VMART (r=0.61, P<0.01) and V30m (r=0.53, P<0.05). VMART correlated with BlaMART (r=0.71, P<0.01) and V30m (r=0.96, P<0.001) but not with VO2max0 or VO2max7. Middle-distance runners had a significantly (P<0.001) higher Vmax0, VMART BlaMART and V30m than triathletes and cross-country skiers, but no significant differences were found between the three groups in VO2max0, VO2max7 or Vmax7. We conclude that so-called muscle power factors, e.g. VMART, V30m and BlaMART, contribute to peak treadmill running performance and especially to horizontal running performance and that VO2max contributes more to uphill than horizontal running performance.
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PMID:Muscle power factors and VO2max as determinants of horizontal and uphill running performance. 1100 96

An HLA-A2-positive patient with advanced stage IV melanoma was vaccinated with dendritic cells (DCs) pulsed with melanoma antigens, whereby the rapid progression of disease stalled for a period of 10 months. Monitoring of the cellular immune response against one of the vaccinated HLA-A2-restricted epitopes demonstrated both induction and subsequent decline in the number of interferon-gamma (IFN-gamma)-producing MART-1-reactive cells present in the blood. Enumeration of reactive T cells by MART-126-35/HLA-A2 tetramer staining revealed an induction of such cells after three vaccinations and a subsequent decline that most prominent at times of rapid disease progression. However, a substantial number of reactive cells were present even when no MART-1 reactivity was detectable by functional assays. Isolation of such MART-126-35-reactive T cells by means of peptide/HLA-A2-coated magnetic beads demonstrated the persistence of a TCRVbeta14+ T-cell clone in this population over the whole observation period. Intracellular fluorescence-activated cell sorter staining of such TCRVbeta14+ T cells for IFN-gamma and interleukin-2 after maximal stimulation with phorbol 12-myristate 13-acetate/ionomycin revealed an impairment in their capacity to produce cytokines at the end of the observation period. Thus, functional changes of individual T-cell clones, e.g. clonal exhaustion, seem to be responsible for the known discrepancy between functional and phenotype assays for immune monitoring of tumour patients.
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PMID:Longitudinal analysis of MART-1/HLA-A2-reactive T cells over the course of melanoma progression. 1462 28

This study investigated whether in trained middle-distance runners, intermittent short-term graded running performance is affected by a hypobaric hypoxic environment (simulated 2,500 m) (H). Seven male middle-distance runners performed an aerobic performance test and an intermittent short-term graded anaerobic running-performance test (MART) both in H and in a normobaric normoxic environment (N). VO(2max) and OBLA were markedly lower (by 18.1% and 8.7%, respectively) in H than in N. In MART, neither maximal running velocity (V(max)) nor exhaustion-time was different between N and H (454 (7) m min(-1) vs. 451 (6) m min(-1), respectively, and 208.7 (5.2) s vs. 205.7 (4.2) s, respectively). The blood lactate concentration at sub-maximal running speed (425 m min(-1)) was significantly greater in H than in N (paired t-test: P<0.05). These results suggest that, in trained middle-distance runners, intermittent short-term graded running performance is not affected by H, despite a considerable decrease in aerobic power in H during the aerobic performance test.
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PMID:Intermittent short-term graded running performance in middle-distance runners in hypobaric hypoxia. 1581 39