Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0392525 (nephrolithiasis)
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Human Gene/Protein
ZNF365A 13.5
vitamin D-dependent calcium binding protein calbindin 13.5
FAM188B 12.5
chloride channel CLC-5 12.5
CLCN5 11.9
SLC13A2 11.5
kinesin family member 3B 11.5
claudin 16 11.3
PFN3 11.2
CLC-5 11.2
SLC34A1 11.1
SLC3A1 11.1
SLC7A9 11.0
C2orf34 11.0
SLC34A3 10.9
GRHPR 10.8
DGKD 10.7
INMT 10.7
ClC-5 10.7
SDCT1 10.5
AGXT 10.5
RABGAP1 10.4
ZNF21 10.4
ATP6V0A4 10.3
major histocompatibility class II antigen 10.3
SLC22A12 10.2
IKEPP 10.2
OCRL-1 10.2
Su48 10.2
MXD3 10.2
ATP6V1B1 10.2
ZNF365 10.2
claudin-14 10.1
FAM20A 10.1
CLC2 10.1
uropontin 10.0
SLC26A6 10.0
Claudin-16 10.0
LRRC16A 10.0
CFEX 9.9
DGKH 9.8
ZNF81 9.8
SLC2A9 9.8
ZNF41 9.7
chloride channel 7 9.7
alanine-glyoxylate aminotransferase 9.7
GLUT9 9.7
OATL1 9.6
NCCT 9.6
SLC17A3 9.5
putative anion transporter 1 9.5
CLDN19 9.5
OCRL1 9.4
IQCB1 9.4
OCRL 9.4
Rab3-GAP 9.3
ARAF1 9.3
PREPL 9.3
TBC1D20 9.3
CGL2 9.2
sodium-potassium-chloride cotransporter 9.1
barttin 9.0
PH1 9.0
SLC9A3R1 9.0
SAT-1 8.9
WDR72 8.9
EAF2 8.9
RASSF7 8.8
allele c 8.8
Wermer syndrome 8.8
ClC-4 8.8
ovarian cancer G protein-coupled receptor 1 8.7
GANAB 8.7
SLC34A2 8.7
urate transporter 1 8.7
bikunin 8.5
PPM1B 8.5
RGS14 8.4
SLC26A5 8.4
CLCN7 8.4
more...
Disease
WARBM 13.5
nephrolithiasis 13.5
XLN 12.0
AMDM 12.0
Idiopathic hypercalciuria 11.9
Dent's disease 11.8
Enteric hyperoxaluria 11.5
sponge kidney 11.4
Mild hydronephrosis 11.2
Pyeloduodenal fistula 11.2
arthritis deformans 11.2
nephrocalcinosis 11.1
SLC34A3, 11.1
Medullary nephrocalcinosis 11.1
HHRH 11.0
Distal RTA 11.0
fourth disease 11.0
hypercalciuria 10.9
Uric acid nephrolithiasis 10.9
Distal renal tubular acidosis 10.9
hyperoxaluria 10.9
APRT deficiency 10.8
pyohydronephrosis 10.7
Perinephric abscess 10.5
Kelley-Seegmiller syndrome 10.4
cystinuria 10.4
Xanthinuria 10.3
Renal tuberculosis 10.3
Splenic lymphoma 10.2
primary hyperoxaluria 10.2
ureterolithiasis 10.1
Secondary oxalosis 10.1
Renal infarction 10.0
recurrent parathyroid carcinoma 10.0
Renal tubular dysfunction 10.0
Urinary stasis 9.8
Acute and chronic pancreatitis 9.8
Ureteritis cystica 9.8
Chronic pyelonephritis 9.8
Indeterminate colitis 9.7
staghorn calculus 9.7
Papillary adenoma 9.6
Xanthogranulomatous pyelonephritis 9.6
oxalosis 9.5
uricosuria 9.5
Acromesomelic dysplasia 9.5
Splenic hamartoma 9.5
Idiopathic osteoporosis 9.5
Proximal renal tubular acidosis 9.4
urolithiasis 9.3
renal tubular acidosis 9.2
Colovesical fistula 9.2
CGL2 9.2
Lowe syndrome 9.1
pituitary hyperfunction 9.0
primary hyperparathyroidism 8.9
ureteritis 8.9
Parathyroid gland 8.8
Parathyroid gland 8.8
Parathyroid gland 8.8
Renal pelvis 8.8
Chronic interstitial nephritis 8.8
Renal pelvis 8.8
pyonephrosis 8.8
glucose-galactose malabsorption 8.7
FBH1 8.7
XRN 8.6
tophi 8.6
aminoaciduria 8.5
gouty nephropathy 8.5
Parathyroid carcinoma 8.4
DIOS 8.4
Eosinophilic myocarditis 8.4
urinary system cancer 8.3
Benign recurrent intrahepatic cholestasis 8.3
Negative pressure pulmonary edema 8.3
demineralization of bone 8.2
hypophosphaturia 8.2
Reflux nephropathy 8.1
Brown tumor 8.0
more...
Symptom
urethralgia 12.0
renal colic 9.7
renal pain 9.1
swollen scrotum 8.5
hyperosmia 8.4
flank pain 8.1
left lower quadrant pain 7.6
loin pain 7.5
Urge incontinence 7.5
astasia 6.6
polyuria 6.6
Acute urinary retention 6.6
nocturnal polyuria 6.3
hyperemesis 6.3
right lower quadrant pain 6.3
frequent urination 6.1
hyperemesis gravidarum 6.0
livedo 5.8
dysuria 5.7
polydipsia 5.6
physical symptom 5.6
bone pain 5.5
athetosis 5.5
dark urine 5.4
prostatism 5.4
colic 5.4
oliguria 5.3
No adverse effect 5.2
groin pain 5.0
bladder pain 4.9
decreased appetite 4.9
chronic constipation 4.8
acute abdominal pain 4.6
Decreased activity 4.5
urinary frequency 4.4
pleuritic chest pain 4.3
rales 4.2
abdominal pain 4.2
hypotonia 4.2
tonic-clonic seizure 4.2
asthenia 4.2
partial seizure 4.1
paresthesia 3.9
abdominal discomfort 3.8
muscle cramps 3.7
emaciation 3.5
productive cough 3.4
hypoproteinemia 3.4
hepatomegaly 3.4
night sweats 3.3
overweight 3.3
dental pain 3.3
pelvic pain 3.1
lethargy 3.1
back pain 3.0
weakness 3.0
diarrhea 2.9
sleepiness 2.9
dizziness 2.9
enuresis 2.9
constipation 2.8
vomiting 2.7
paresis 2.6
acute pain 2.6
fever of unknown origin 2.5
heartburn 2.5
chills 2.5
tense 2.5
myalgia 2.4
ataxia 2.4
stridor 2.4
nausea 2.3
fatigue 2.3
acidity 2.2
shortness of breath 2.2
acute abdomen 2.0
nausea and vomiting 1.9
spasticity 1.9
low back pain 1.8
ophthalmoplegia 1.8
more...
Drug
Potassium citrate 12.3
LFLX 10.4
Felbatol 10.4
Zonegran 10.4
Gabitril 9.7
Topamax 9.6
Benazepril hydrochloride 9.5
Lotrel 9.5
Gabitril 9.5
lomefloxacin hydrochloride 9.2
Indinavir 9.2
Dyazide 9.0
Carboxyatractyloside 8.7
Nitisinone 8.6
Metolazone 8.5
Tiopronin 8.5
Cinacalcet 8.2
Rasburicase 8.1
Crixivan 7.7
Oxaprozin 7.6
Keppra 7.5
Pyridoxamine 7.4
Rasburicase 7.2
URF 7.0
Zonisamide 7.0
Tenofovir 6.9
PTH 6.8
Plavix 6.6
Hydrochlorothiazide 6.5
Diamox 6.2
Dilantin 6.2
Beta-2 6.2
Indapamide 6.0
PMPA 5.9
Calcium chloride 5.7
Ammonium chloride 5.7
DMSA 5.6
Isradipine 5.5
Rimonabant 5.2
Colombo 5.2
Coumadin 5.1
Teriparatide 5.1
Indapamide 5.1
ATV 5.0
CTT 4.9
Gabapentin 4.7
Nephron 4.7
EHDP 4.6
Denosumab 4.4
Tuberculin 4.4
Meropenem 4.3
Oseltamivir 4.3
Meropenem 4.2
Fluconazole 4.2
Nephron 4.1
NAG 4.1
PMEA 4.0
Coral 3.9
Rosiglitazone 3.9
NVP 3.6
CTC 3.5
Clopidogrel 3.4
Infliximab 3.4
Infliximab 3.4
Fragment 3.4
Vitamin B 3.3
DPA 3.2
CTC 3.2
ROC 3.2
Phenytoin 3.2
CTA 3.1
Glycyrrhiza 3.1
Growth hormone 3.0
Amiloride 3.0
Growth hormone 3.0
Indomethacin 2.9
citric acid 2.9
Activin 2.8
PTC 2.8
Dial 2.7
more...
Enzyme
glyoxylate reductase 9.3
glyoxylate reductase 9.2
4-hydroxy-2-oxoglutarate aldolase 8.9
AGT 7.1
adenine phosphoribosyltransferase 7.1
hydroxypyruvate reductase 7.1
homogentisate 1,2-dioxygenase 7.0
hydroxypyruvate reductase 6.9
oxalate decarboxylase 6.8
oligopeptidase B 6.6
PNL 6.1
xanthine dehydrogenase 6.1
glycolate oxidase 6.1
HK2 6.0
4-hydroxyphenylpyruvate dioxygenase 5.7
hypoxanthine-guanine phosphoribosyltransferase 5.7
oxalate oxidase 5.7
uricase 5.6
PRPP synthetase 5.6
citrate lyase 5.4
MsrA 5.2
nucleotide pyrophosphatase 5.0
CGT 4.8
carbonic anhydrase 4.6
urease 4.5
urease 4.5
1-hydroxylase 4.4
alanine aminopeptidase 4.0
FAST 4.0
lactic acid dehydrogenase 4.0
prolyl endopeptidase 3.9
xanthine oxidase 3.8
PAT 3.8
IMP dehydrogenase 3.7
cystathionine beta-synthase 3.6
diacylglycerol kinase 3.6
gamma-glutamyl transpeptidase 3.0
leucine aminopeptidase 2.9
paraoxonase 2.8
lactate dehydrogenase 2.8
pyruvate dehydrogenase 2.8
pyruvate dehydrogenase 2.8
hexosaminidase 2.7
cathepsin K 2.7
alkaline phosphatase 2.6
DCF 2.6
NADPH oxidase 2.5
NADPH oxidase 2.4
pyruvate dehydrogenase 2.1
glucose-6-phosphatase 2.0
renin 1.9
aldolase 1.8
CD13 1.7
ATPase 1.7
ACE 1.7
caspase-9 1.7
superoxide dismutase 1.6
alpha-glucosidase 1.5
calcineurin 1.5
hyaluronidase 1.4
catalase 1.2
ceruloplasmin 1.2
reverse transcriptase 1.2
glutathione peroxidase 1.1
hyaluronidase 0.9
creatine kinase 0.9
thromboplastin 0.8
complex I 0.4
endonuclease 0.4
glutathione reductase 0.3
urokinase-type plasminogen activator 0.2
lysozyme 0.2
luciferase -0.1
acid phosphatase -0.1
AMP-activated protein kinase -0.1
peroxidase -0.1
phospholipase A2 -0.3
focal adhesion kinase -0.3
RNase -0.5
thrombin -0.5
more...
Compound
Indinavir sulfate 11.2
5C-aglycone 10.2
Visnagin 9.8
oxalate 9.3
Indinavir 9.2
Cosyntropin 8.4
Triamterene 8.4
Magnesium hydroxide 8.2
Melamine 8.0
Topiramate 8.0
Praxilene 8.0
Thiazide 7.9
Zonisamide 7.9
Uric acid 7.9
PH2 7.6
Hexachlorobutadiene 7.6
Cystine 7.4
Pyridoxamine 7.3
oxalic acid 7.2
Chlorthalidone 7.1
Xanthine 7.1
D 3 7.0
Cystine 6.9
Aluminum hydroxide 6.9
3-Deazaneplanocin 6.8
25-Hydroxyvitamin D 6.8
Glyoxylate 6.8
HPP 6.6
CIT 6.6
Triphosphate 6.6
Retigabine 6.6
N-methylnicotinamide 6.5
HPT 6.4
Hydrochlorothiazide 6.2
Tiagabine 6.2
Tannin 6.1
SHA 6.0
Ceftriaxone 6.0
Mesalamine 5.9
Oxcarbazepine 5.9
Ritonavir 5.9
2-aminobenzamide 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
Potassium chloride 5.7
SDA 5.6
Ephedrine 5.5
Chlorambucil 5.4
vitamin D 5.3
Apocynin 5.3
25-dihydroxycholecalciferol 5.2
calcium 5.2
Lamotrigine 5.0
creatinine 5.0
Hypoxanthine 5.0
Oseltamivir 4.9
Vitamin D 4.8
Xylitol 4.8
EHDP 4.8
Lawson 4.8
Sulfasalazine 4.7
Crocin 4.7
Pyrazinamide 4.6
PMEA 4.6
Triptolide 4.6
Norfloxacin 4.5
more...