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Query: UMLS:C0392525 (nephrolithiasis)
 2,669 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Manifestations of xanthogranulomatous pyelonephritis in 26 patients closely mimicked those of neoplastic and other inflammatory renal parenchymal diseases. Middle-aged or older women were affected most often. Most patients presented with anemia, chronic febrile illness, a painful tender flank mass and recurrent urosepsis. Some features of nephrogenic hepatic dysfunction were present in 13 patients. Bacterial cultures of renal tissue were almost always positive but the spectrum differed considerably from that of the bladder urine. Urographically, a renal mass lesion was encountered in 62% of the patients, nephrolithiasis in 38% and a functionless kidney in 27%. Angiographically, none of the 4 mass lesions studied was distinguished from hypernephroma. Indeed, a correct preoperative diagnosis was made in only 1 instance. There were 3 stages of xanthogranulomatous pyelonephritis recognized. Treatment consisted of nephrectomy for diffuse or advanced stage disease or both (21 patients), excision of the diseased renal segment for localized and low stage disease (2 patients) and renal biopsy (3 patients). Xanthogranulomatous pyelonephritis did not recur but in some patients bacteriuria continued or hypertension developed.
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PMID:Xanthogranulomatous pyelonephritis: a critical analysis of 26 cases and of the literature. 66 Jul 25

The genitourinary tract is well recognized as a route through which bacteria could gain access to the blood circulation. Under some circumstances, metastatic infections may occur in distant organs, including endogenous endophthalmitis. Xanthogranulomatous pyelonephritis (XGP) is an unusual variant of chronic pyelonephritis. It most often occurs in middle-aged women who frequently have a history of recurrent urinary tract infections combined with obstruction and a kidney of poor function. We reported an unusual case of urinary tract infection in a non-nephrolithiasis and non-obstructive urinary tract complicated by Klebsiella pneumoniae endogenous endophthalmitis and developed XGP in two months.
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PMID:Unusual clinical presentation of Klebsiella pneumoniae induced endogenous endophthalmitis and xanthogranulomatous pyelonephritis in a non-nephrolithiasis and non-obstructive urinary tract. 1238 Sep 13

Xanthogranulomatous pyelonephritis (XGPN) is a chronic renal infection typically associated with nephrolithiasis and a non-functioning kidney. Renal tuberculosis is a major cause of morbidity in developing countries. Despite recent advances in diagnosis, it is sometimes difficult to differentiate renal tuberculosis preoperatively from XGPN. We present herewith a case report of a patient who was preoperatively diagnosed with a right non-functioning kidney due to renal calculus with stage 3 XGPN and adjacent liver abscess on computed tomography. Subsequent histopathological examination of the nephrectomised specimen revealed renal tuberculosis. To our knowledge this is the first case of renal tuberculosis spreading to the liver and causing liver abscess formation which was misdiagnosed as XGPN preoperatively.
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PMID:Renal tuberculosis simulating xanthogranulomatous pyelonephritis with contagious hepatic involvement. 1644 35

Xanthogranulomatous pyelonephritis (XGP) is invariably associated with urinary tract obstruction, infection and nephrolithiasis. We report an unusual case of XGP occurring in an immunosuppressed patient in the absence of either urinary obstruction or nephrolithiasis, presenting as a diagnostic dilemma, and highlighting the possible role of glucocorticoid immunosuppression towards its pathogenesis.
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PMID:An unusual case of xanthogranulomatous pyelonephritis in an immunosuppressed patient with systemic lupus erythematosus. 1723 48

A 73-year-old woman with leukemia presented with urinary tract infection, splenic abscess, and a renal mass. Both urine culture and pus culture of the splenic abscess yielded Klebsiella pneumoniae. Percutaneous biopsy of the renal mass confirmed the diagnosis of xanthogranulomatous pyelonephritis. Because of high risk for surgery, the patient received treatment with antibiotic therapy for 2 months. With antibiotic therapy, not only was the splenic abscess cured but follow-up ultrasonography also showed progressive resolution of the renal mass. Xanthogranulomatous pyelonephritis is frequently associated with urinary tract obstruction or nephrolithiasis. In this first report of xanthogranulomatous pyelonephritis in a patient with leukemia and splenic abscess, we provide a short review of xanthogranulomatous pyelonephritis successfully treated with antibiotics only.
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PMID:Xanthogranulomatous pyelonephritis successfully treated with antibiotics only. 1911 30

Nephrobronchial fistula is a rare complication seen in association with renal infections, trauma or stone disease. Xanthogranulomatous pyelonephritis (XGP) is an infectious disease with a potential for fistulization to lung, skin, colon and other organs. We present a case of nephrolithiasis complicated by obstruction leading to pyonephrosis and nephrobronchial fistula, treated successfully by nephrectomy and excision of fistulous tracts. Nephrobronchial fistula, although a rare complication of longstanding renal stone, should be considered when a patient presents with perirenal suppurative process. This clinical case illustrates the natural history of nephro-bronchial fistula and the relevance of early treatment of nephrolithiasis.
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PMID:Nephrobronchial fistula complicating neglected nephrolithiasis and xanthogranulomatous pyelonephritis. 2156 18

Xanthogranulomatous pyelonephritis (XPN) is a rare inflammatory condition usually secondary to chronic obstruction caused by nephrolithiasis and resulting in infection and irreversible destruction of the renal parenchyma. Its standard therapy consists of total or partial nephrectomy. A case of stage III xanthogranulomatous pyelonephritis treated with antibiotherapy and percutaneous drainage is presented in this paper.
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PMID:Stage III xanthogranulomatous pyelonephritis treated with antibiotherapy and percutaneous drainage. 2198 Jul 41

Xanthogranulomatous pyelonephritis (XGP) is a rare, serious, debilitating illness characterised by an infectious renal phlegmon. Most cases of XGP are unilateral and are often associated with urinary tract obstruction, infection, nephrolithiasis, diabetes, and/or immune compromise. This disease process ultimately results in focal or diffuse renal destruction and is characterised pathologically by lipid-laden foamy macrophages. XGP occurs in approximately 1% of all renal infections. The kidney is usually non-functional. XGP displays neoplasm like properties capable of local tissue invasion and destruction and has been referred to as a pseudotumour. Adjacent organs including the spleen, pancreas or duodenum may be involved. The gross appearance of XGP is a mass of yellow tissue with regional necrosis and haemorrhage, superficially resembling renal cell carcinoma. Renal cell carcinoma may be indistinguishable from XGP radiographically and clinically. The treatment of XGP is almost universally extirpative and can pose a formidable challenge to the surgeon.
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PMID:Chronic flank pain, fever and an unusual diagnosis. 2267 66

Xanthogranulomatous pyelonephritis (XGP) is a destructive inflammatory process which is frequently caused by recurrent urinary tract infections or chronic obstruction by kidney stones. We present a 56-year-old female with an extensive retroperitoneal urinoma and xanthogranulomatous pyelonephritis of the lower pole moiety in a kidney with a duplicated collecting system due to obstructive nephrolithiasis. After drainage of the urinoma, the patient underwent a definitive lower pole heminephrectomy with preservation of the functional upper pole. We review important clinical features of xanthogranulomatous pyelonephritis and considerations for surgery on a duplicated kidney.
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PMID:Xanthogranulomatous Pyelonephritis of a Lower Pole Moiety in a Duplicated Collecting System Kidney. 2643 73

Xanthogranulomatous pyelonephritis (XGP) is a rare benign condition with unknown aetiology and chronic infection of kidney. Commonly, most cases are related with urinary tract obstruction, nephrolithiasis, infection, diabetes, and/or immune compromise. XGP is associated with destruction of the renal parenchyma and granulomatous inflammation with foamy lipid-laden macrophages resulting from obstructive uropathy. It closely mimics a malignancy, exhibiting local tissue invasion and destruction. Adjacent organs especially duodenum as well as very rarely pancreas or spleen may be involved. Additionally, XGP is known as notorious for fistulisations, such as pyelocutaneous and ureterocutaneous fistulae, which have been reported as well described. XGP may be indistinguishable from renal cell carcinoma by radiographic and clinic consultation so it must be diagnosed based on the histopathologic examinations. Furthermore, macroscopic appearance of XGP is a mass of yellow tissue with focal haemorrhage besides necrosis and in this regard, it grossly resembles renal cell carcinoma. Here, we report the case of a 32-year-old female, preoperatively diagnosed as malignancy by clinical examination. Our further pathological evaluations revealed very rarely adhesion of XGP to pancreas tissue.
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PMID:Xanthogranulomatous pyelonephritis: a case with rare adhesion to pancreas. 2917 41


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