Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0392326 (discomfort)
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Human Gene/Protein
transient receptor potential cation channel, subfamily M, member 8 8.9
VMAC 8.2
Prolactin-induced protein 7.7
HSCB 7.5
FRMD5 7.3
envelope polyprotein 7.3
MMP23B 7.3
cornifelin 7.0
PATE 6.9
AdPLA 6.8
GLRA3 6.8
V2-6 6.6
VIPL 6.5
BRAP2 6.5
CLAN 6.5
PLA2G16 6.5
mucosal vascular addressin cell adhesion molecule 1 6.3
STL3 6.2
V1-4 6.2
BAP-1 6.1
NIBP 6.0
histamine receptor H1 5.9
angiopoietin-3 5.9
BGR 5.8
OAF 5.7
EMP2 5.7
XYLT2 5.6
GLC3A 5.6
Wah 5.5
TDAG8 5.5
V4-6 5.4
CCBE1 5.4
BTBD9 5.4
PIPP 5.4
PDYN 5.3
Interleukin 17A 5.3
CYP4F22 5.3
SOLO 5.2
HS6ST1 5.2
ST8SIA4 5.2
CCKBR 5.1
desmosomal glycoprotein 1 5.1
XT2 5.1
CNTN3 5.0
NIP1 5.0
Dermatopontin 5.0
mitochondrial aldehyde dehydrogenase 2 5.0
CMPD 5.0
CLIP2 5.0
PG-Lb 5.0
FLIR 5.0
MISS 4.9
ZFHX1B 4.9
TBX4 4.9
UBF1 4.9
CEAP 4.8
KMO 4.8
LSM1 4.7
SEMG 4.7
ILF 4.7
IMP2 4.7
tec 4.7
UST 4.6
FAG 4.6
ZAR1 4.6
VDP 4.6
MFT 4.6
MUC5AC protein 4.5
fibrinogen alpha chain 4.5
LARS 4.5
DPM1 4.5
LDC 4.5
PRK 4.5
keratin 9 4.4
V1-3 4.4
NUDT15 4.4
Serotonin receptor 4.4
DSG1 4.4
HLA-B*13 4.4
SLAP 4.3
more...
Disease
Dental discomfort 10.5
Self-incineration 10.5
Other esophageal disorders 10.5
Acquired Deafness 10.5
Bronchial polyps 10.5
Sleep Bruxism 10.5
SPPK1 10.5
Premenstrual pain 10.5
melanemia 10.5
Trophic leg ulcer 10.5
Venous lake 10.5
Idiopathic vulvodynia 10.5
Extraskeletal Ewing's sarcomas 10.5
Infestation by land leeches 10.5
metastatic gastrointestinal carcinoid tumor 10.5
Rectovesical fistula 9.5
Spinal claudication 9.5
Synchysis scintillans 9.5
infective sinusitis 9.5
Diabetic gastropathy 9.5
Uncomplicated diverticular disease 9.5
Chronic eczema 9.5
Vestibular papillomatosis 9.5
Carcinomatous pleurisy 9.5
Follicular conjunctivitis 9.5
Vulval edema 9.5
Butting 9.5
Acute iritis 8.9
Non-bacterial prostatitis 8.9
Granular myringitis 8.9
Herpetic stomatitis 8.9
Corlett 8.7
Chronic post-thoracotomy pain 8.5
Macrodactylia 8.5
Tuberculous epididymo-orchitis 8.5
Epithelioid leiomyosarcoma 8.5
Syphilitic aortic aneurysm 8.5
Pearly penile papules 8.5
eustachian salpingitis 8.5
Axillary vein thrombosis 8.5
Splenic cyst 8.5
Psychogenic vomiting 8.5
recurrent malignant mesothelioma 8.5
Acute gangrenous cholecystitis 8.5
Ocular discomfort 8.3
Acute dermatitis 8.2
Staphylococcus aureus mediastinitis 8.2
Anterior epistaxis 8.2
Purulent peritonitis 8.2
Involutional entropion 8.2
Aqueous tear deficiency 8.2
stage III renal cell carcinoma 8.2
Generalized hyperhidrosis 8.2
Superior limbic keratoconjunctivitis 8.2
Postoperative chest infection 8.2
Gangliocytoma 8.2
relationship disorder 8.2
Bicipital tendinitis 8.2
psychological disability 8.1
Tooth surface loss 8.0
cancer seeding 7.9
Aquagenic pruritus 7.9
Thyrotoxicosis factitia 7.9
Conjunctivochalasis 7.9
Mauclaire 7.9
Situational anxiety 7.9
Postoperative urinary tract infection 7.9
Gastrointestinal fistula 7.9
Pelvic hemorrhage 7.9
Functional dyspepsia 7.8
Eosinophilic gastritis 7.7
Psychophysiological insomnia 7.7
Psychogenic cough 7.7
Clitoris 7.7
Xanthine oxidase deficiency 7.7
Pyogenic hepatic abscess 7.7
Perianal Paget's disease 7.6
Atypical endometrial hyperplasia 7.5
Pseudofolliculitis 7.5
Xerosis cutis 7.5
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Symptom
Lumbar syndrome 10.5
Shoulder discomfort 10.5
Idiopathic scrotal edema 10.5
Thyroid pain 10.5
Rough mouth 10.5
discomfort 10.5
Foot discomfort 10.5
Back discomfort 10.5
Arm discomfort 10.5
Leg discomfort 10.5
Eyelid margin hyperemia 10.5
discomfort 10.3
Visual discomfort 10.3
Musculoskeletal discomfort 10.0
Nasal discomfort 9.5
Sensation of warmth 9.5
Postoperative constipation 9.5
symptoms; development 9.5
redness of the nose 9.5
Neck discomfort 9.5
Epigastric discomfort 9.5
Breast discomfort 9.2
General discomfort 8.9
Intercostal neuralgia 8.9
trigonal irritation 8.9
Pruritus of pregnancy 8.9
GI pain 8.8
prostatic tenderness 8.7
change in bowel movements 8.7
Vulval pain 8.5
Anorectal pain 8.5
Phonophobia 8.3
Auspitz's sign 8.2
Oral discomfort 8.2
glossopyrosis 8.2
feeling of choking 8.2
Chest discomfort 8.1
Early satiety 8.0
ovulatory bleeding 7.9
Oral Manifestations 7.9
Vocal fatigue 7.9
Lid lag 7.9
Gastrointestinal discomfort 7.9
feeling of malaise 7.7
Rebound tenderness 7.7
Scintillating scotoma 7.7
respiratory pain 7.7
vulval irritation 7.7
sacralgia 7.7
Mild pain 7.6
Rectal sensation 7.6
skin pain 7.5
Transient neurological symptoms 7.5
feeling dizzy 7.4
Other pain 7.4
Dyspnea at rest 7.3
Throat symptoms 7.3
change in stool 7.2
Purulent discharge 7.2
Incisional pain 7.2
swollen penis 7.2
Penile pain 7.2
Perineal pain 7.2
Refractory angina pectoris 7.2
Chills and fever 7.2
sinus pain 7.2
bloating 7.0
throat irritation 7.0
vaginal discomfort 7.0
skin impairment 7.0
Vulvodynia 7.0
Cutaneous allodynia 6.9
Homan's sign 6.9
Radiating pain 6.9
feeling faint 6.9
intestinal pain 6.9
Vaginal dryness 6.9
belching 6.8
Lung hernia 6.8
Muscle tenderness 6.8
more...
Drug
Ricinoleic Acid 10.5
Bucladesine sodium 9.5
Alfenta 9.5
Tecadenoson 9.5
Histrelin acetate 8.9
Scopolia extract 8.9
Deracoxib 8.5
Methadyl acetate 8.5
Alosetron 8.3
Privine 8.2
Meteneprost 8.2
Hexabrix 320 8.1
Lacrisert 7.9
IHMS 7.7
Cerebyx 7.7
Protonix 7.7
Emla 7.6
Emla 7.6
Percocet 7.5
Calcium polycarbophil 7.5
Podofilox 7.5
Iopentol 7.4
Tegaserod 7.3
Darvon 7.2
Ultiva 7.2
Mosapride citrate 7.2
Cilansetron 7.2
Blenoxane 7.2
Azopt 7.2
Versed 7.1
Thyrogen 7.1
Tegaserod 7.0
Myfortic 7.0
Ecabet sodium 7.0
Pro-Banthine 7.0
Emla 7.0
Patanol 7.0
Pantoprazole sodium 6.9
Propine 6.9
Torecan 6.9
Torecan 6.9
Medicon 6.8
Quinine sulfate 6.8
Sarpogrelate hydrochloride 6.8
Citanest 6.7
Citanest 6.7
Tantum 6.7
Selenium sulfide 6.7
Amethocaine 6.7
Apomorphine hydrochloride 6.7
Iotrolan 6.6
Roquinimex 6.6
Octapressin 6.6
Concor 6.6
Iodixanol 6.5
C2H5Cl 6.5
Azelastine hydrochloride 6.5
Pranoprofen 6.5
Ganda 6.5
Medicon 6.4
Citrus unshiu peel 6.4
Calamine 6.4
Elmiron 6.4
Omniscan 6.4
Isopaque 6.4
Mizolastine 6.3
Avanafil 6.3
Dioctyl sodium sulfosuccinate 6.3
Conray 6.3
Methyl aminolevulinate 6.3
Cetrotide 6.2
Novafil 6.2
Buscopan 6.2
Pentosan polysulfate sodium 6.2
Myo-Inositol 6.2
Cefbuperazone 6.2
Iohexol 6.1
Riopan 6.1
Calcium acetate 6.1
Marcaine 6.1
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Enzyme
PATE 6.7
NAAT 5.0
RGP 4.6
CTS2 3.7
alliinase 3.5
SOR 3.5
homoserine kinase 3.4
PWD 3.4
IOR 3.2
inosine triphosphatase 3.2
NMT 3.1
phosphoribulokinase 3.0
HDR 2.8
chymopapain 2.8
DAT 2.8
chymopapain 2.7
TDH 2.7
ancrod 2.7
BIS 2.6
PPH 2.5
HVS 2.5
lactase 2.4
estrogen sulfotransferase 2.3
hyaluronidase 2.3
CAD 2.3
CAD 2.3
EPT 2.3
CCS 2.3
CAD 2.2
VOR 2.2
SCS 2.1
PNL 2.1
FPS 2.0
SOR 2.0
PRE 1.9
rhodopsin kinase 1.9
MCS 1.9
cathepsin C 1.9
hyaluronidase 1.9
CFI 1.8
alpha-galactosidase 1.7
creatine kinase 1.7
DMT 1.6
prostate-specific antigen 1.4
SPT 1.4
thiopurine methyltransferase 1.4
meprin 1.4
PTA 1.3
CDH 1.3
AOR 1.3
tryptophan hydroxylase 1.3
botulinum neurotoxin 1.2
CPM 1.1
tryptase 1.0
glycerol kinase 1.0
TACE 0.8
BAT 0.8
PST 0.8
AST 0.7
FFT 0.7
aldehyde dehydrogenase 0.7
aldehyde dehydrogenase 0.7
diacylglycerol acyltransferase 0.7
aldehyde dehydrogenase 0.7
MDP 0.7
SPT 0.7
BMA 0.6
prostaglandin synthetase 0.6
aldehyde dehydrogenase 0.6
carbonic anhydrase 0.6
urease 0.6
interstitial collagenase 0.6
gamma-glutamyl transpeptidase 0.5
bromelain 0.5
aldehyde dehydrogenase 0.5
thymidine phosphorylase 0.5
urease 0.5
lysin 0.4
CPT 0.4
aldolase 0.3
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Compound
Pramoxine 10.5
Papyriferic acid 10.5
Papyriferic acid 9.5
Lincomycin hydrochloride 8.9
S 31 8.9
9,10-Anthracenedicarboxaldehyde 8.5
Brinzolamide 8.3
Alverine citrate 7.9
Gadodiamide 7.5
Moxisylyte hydrochloride 7.5
11(R)-HETE 7.5
Mebeverine hydrochloride 7.3
Deaner 7.2
Torecan 6.9
2,4-Di-tert-butylphenol 6.8
Doxepin hydrochloride 6.8
Ketaset 6.7
2,4-Di-tert-butylphenol 6.7
2ip 6.7
2,4-DCA 6.7
Dipivefrin 6.6
I-123 BMIPP 6.6
Cyclobenzaprine 6.6
Isopaque 6.4
Metaxalone 6.4
lauramide 6.4
Apomorphine hydrochloride 6.4
L-Proline, 6.3
Metipranolol 6.3
PDQ 6.2
Cytembena 6.2
ST-37 6.2
Eflornithine 6.2
Levobunolol 5.9
Dicyclomine 5.9
Fosphenytoin 5.8
MHT 5.8
Pivampicillin 5.7
Rhizoxin 5.7
Josamycin 5.6
Josamycin 5.6
4-methylquinazoline 5.6
Josamycin 5.6
Prilocaine 5.5
Betnesol 5.5
SMP2 5.4
Sucralfate 5.4
1-methoxy-2-propanol 5.4
EPB 5.3
octyl acetate 5.3
Ditan 5.3
Bixin 5.2
Bixin 5.2
2-methylpropanamide 5.2
Azaperone 5.2
Tolterodine 5.2
Methylxanthine 5.1
Mafosfamide 5.1
Cisapride 5.1
3-O-methyldopamine 5.0
Clemastine 5.0
Rocuronium 5.0
Dorzolamide 5.0
Mephenytoin 4.9
Pantethine 4.9
Prochlorperazine 4.9
Etidocaine 4.9
tropic acid 4.9
MTN 4.9
Quine 4.8
Etoricoxib 4.8
PBZ 4.8
Methazolamide 4.8
Oxymetazoline 4.8
Ketorolac 4.8
Fexofenadine 4.8
Proflavine 4.7
gamma-CEHC 4.7
Lapachol 4.7
Flavone acetic acid 4.7
more...