Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0392326 (discomfort)
 22,423 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the diapered area, the continuous exposure to excess moisture and irritants from urine and feces weakens the stratum corneum, making the skin more susceptible to irritation. The use of wet wipes for infants (baby wipes) is a common practice to clean skin after urine or a bowel movement, and this practice even extends to cleaning the hands and face, resulting in repeated daily use. Therefore, ensuring that baby wipes contain ingredients that are safe and mild on skin is important to help minimize skin irritation and discomfort. While disposable baby wipes have been shown to be effective and gentle at cleaning infant skin, even the skin of premature infants, there is growing public concern regarding their safety and tolerability. Not all products are made the same, as differences exist in manufacturing processes, ingredients, materials, safety, and quality testing. Therefore, it is important that healthcare professionals have accessible evidenced-based information on the safety and tolerability of common ingredients found in baby wipes to optimally educate their patients and families. Herein, we provide a review on best practices for ingredient selection, safety, and efficacy of baby wipes.
 ...
PMID:The science behind wet wipes for infant skin: Ingredient review, safety, and efficacy. 3206 66

We propose a novel electrocardiogram (ECG) denoising technique using the variable frequency complex demodulation (VFCDM) algorithm. We used VFCDM to perform the sub-band decomposition of the noise-contaminated ECG to remove the noise components so that accurate QRS complexes could be identified. The ECG quality was further improved by removing baseline drift and smoothing via adaptive mean filtering. The proposed method was validated on the MIT-BIH arrhythmia database (MITDB) and wearable armband ECG data. For the former, we added Gaussian white noise to the ECG signals at different signal-to-noise ratios and the denoising performance of the proposed method was compared with other denoising techniques. The proposed approach showed superior denoising performance compared to the other methods. We compared the QRS complex detection performance of the noisy to the denoised armband ECG. The performance of the proposed denoising method on the armband ECG resulted in comparable QRS complex detection as that obtained when using Holter monitor ECG signals. This demonstrates that the proposed algorithm can significantly increase the amount of usable armband ECG data, which would otherwise have been discarded due to electromyogram contamination especially during arm movements. Hence, the proposed algorithm has the potential to enable long-term monitoring of atrial fibrillation using the armband without the discomfort of skin irritation often experienced with Holter monitors.Clinical Relevance- The proposed ECG denoising method can significantly increase the ECG quality of wearable ECG devices, which are more susceptible to muscle and motion artifacts.
 ...
PMID:Denoising Wearable Armband ECG Data Using the Variable Frequency Complex Demodulation Technique. 3301 58

Heart rate (HR) measurement is crucial for newborn infant monitoring in the neonatal intensive care unit (NICU). The widely used contact HR measurement methods based on electrocardiography (ECG) and photoplethysmography (PPG) signals can lead to discomfort and possible skin irritation on neonates, which limit its application in NICU scenarios. In this work, we propose a non-contact HR monitoring method simply using a RGB camera. Eulerian video magnification (EVM) is employed to detect the subtle changes of neonatal faces results from blood circulation. The magnified signal is then transformed to the spectral domain to extract HR information. Compared with the widely investigated independent component analysis (ICA)-based HR measurement method using video recordings, the proposed method can achieve the real time HR measurement, which is a significant superiority in NICU neonatal monitoring. To the best of our knowledge, this is the first study to employ EVM algorithm in real time neonatal HR monitoring.
 ...
PMID:Non-Contact Heart Rate Monitoring in Neonatal Intensive Care Unit using RGB Camera. 3301 98

The conventional use of prosthetic custom-design socket is affected by discomfort related to wellknown problems: sweating, sores or skin irritation, excessive weight and harness, impaired body image, that lead to a high rate of abandonment. Osseointegrated prosthetic implants for limb amputation are progressively evolving to overcome limitations of socket. The aim of this article is to present a systematic review of the use, safety in terms of rate of infection and complications, and reported outcomes of upper and lower limb osseointegrated prosthetic implants. A systematic search was carried out for studies that evaluated outcomes of osseointegration technique in case of upper and lower limb amputees according to the PRISMA guidelines with a PRISMA checklist and algorithm. MINORS score was used for methodologic assessment. 17 articles about the treatment of patients with upper or lower limb amputation treated with an osseointegrated prostesis were included. The overall rate of infections was 32%. All the clinical outcomes reported were related to lower limb. No clinical data for upper limb was found. The postoperative mean value of MCS and PCS SF-36 and Q-TFA was 55.1, 45.4 and 73.8 respectively, while six minute walk test (6MWT) and the timed up and go (TUG) test scored an average value of 388 meters and 11.5 seconds respectively. MINORS score ranged from 5 to 13, with a median of 11 [interquartile range (IQR), 9-11]. The osseointegration is associated to a high rate of postoperative complications but, significant improvement in clinical outcomes compared to preoperative time are shown. The data available from the literature are limited but suggest good clinical outcomes and significant survivorship of the implants. Further clinical studies are needed to establish which kind of implant is associated to higher clinical performance and lower rate of postoperative complications and infections.
 ...
PMID:Osseointegration for lower and upper-limb amputation a systematic review of clinical outcomes and complications. 3326 Dec 96


<< Previous 1 2 3 4 5