Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0376358 (prostate cancer)
 59,338 document(s) hit in 31,850,051 MEDLINE articles (0.04 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
prostate-specific antigen 5249
androgen receptor 4753
Sep 3796
Mol 3784
PC-3 3476
PSA 2886
PC3 2685
prostate specific antigen 1567
p53 1251
MRI 1056
prostate-specific membrane antigen 975
caspase-3 753
Bcl-2 752
AKT 723
Men 693
PTEN 684
p21 612
PI3K 599
ERG 594
prostatic acid phosphatase 525
mTOR 506
E-cadherin 506
cytokine 506
TMPRSS2 503
histone 486
insulin 454
LHRH 441
vascular endothelial growth factor 418
Androgen receptor 402
PSMA 398
estrogen receptor 391
cyclin D1 388
reductase 379
PARP 359
nodal 358
NMR 356
MAPK 339
catenin 321
epidermal growth factor receptor 316
tyrosine kinase 302
p27 301
cage 298
ERK 297
acid phosphatase 289
ERK1 286
proteasome 274
AR protein 272
collagen 271
alkaline phosphatase 271
endoplasmic reticulum 270
TRAMP 264
epidermal growth factor 259
p38 259
insulin-like growth factor 256
CD44 251
matrix metalloproteinase 246
Ki-67 244
c-Myc 244
VEGF 244
tumor necrosis factor 238
MMP-9 237
vimentin 233
nuclear receptor 232
STAT3 231
IL-6 227
phosphatase 225
FGF8 224
BRCA1 222
ATP 219
glycoprotein 219
caspase-9 216
BRCA2 214
EGFR 211
histone deacetylase 208
survivin 205
serine protease 204
annexin V 204
CD8 202
UTR 198
interleukin-6 194
ubiquitin 191
caspase-8 190
EGF 189
bcl-2 187
ACS 183
fibronectin 181
fused 178
JNK 177
urokinase-type plasminogen activator 177
kallikrein 173
MMP-2 173
MYC 173
pT3 168
cyclin 168
TNM 167
cytochrome c 167
FDG 166
proliferating cell nuclear antigen 166
N-cadherin 161
IGF-I 161
kit 159
NKX3.1 157
Prostate specific antigen 157
TNF 155
p65 154
ROS 152
phosphatidylinositol 3-kinase 151
hereditary prostate cancer 151
histone H3 150
HER2 148
bombesin 145
prolactin 145
c-Jun 144
vitamin D receptor 144
chemokine 142
CD4 140
beta-catenin 140
PEG 140
aromatase 139
osteosarcoma 137
tumour suppressor 137
CYP17 135
interferon 134
COX-2 133
GSTP1 132
EZH2 131
IL-8 131
AMACR 130
c-myc 128
cyclooxygenase-2 127
TGF-beta 126
extracellular signal-regulated kinase 125
MEK 124
polypeptide 123
cytochrome P450 122
threonine 122
hemoglobin 119
somatostatin 117
TRAIL 117
p63 115
IFN 115
phosphatase and tensin homolog 114
PIN 114
CXCR4 113
Fas 113
receptor tyrosine kinase 113
cyclin-dependent kinase 112
Rho 110
cytokeratin 110
chromogranin A 110
RANKL 109
KLK3 108
IGF-1 108
p300 108
poly(ADP-ribose) polymerase 107
albumin 107
Sp1 107
cyclin E 106
metastasis suppressor 106
ATM 105
more...
Disease
prostate cancer 59338
cancer 28040
tumor 15437
metastases 4693
breast cancer 3352
Prostate Cancer 3281
carcinoma 3194
PSA 2886
tumor growth 2340
carcinogenesis 1908
adenocarcinoma 1896
tumor progression 1876
tumorigenesis 1600
bone metastases 1376
lung cancer 1252
melanoma 908
aggressiveness 883
prostatic adenocarcinoma 877
PIN 808
bladder cancer 787
colorectal cancer 726
leukemia 633
colon cancer 613
primary tumor 541
ovarian cancer 538
diabetes 517
obesity 476
renal cell carcinoma 458
incontinence 440
osteoporosis 440
MCF 433
prostatic disease 419
erectile dysfunction 393
hepatocellular carcinoma 386
multiple myeloma 384
prostatitis 374
pancreatic cancer 356
gastric cancer 349
seminal vesicles 326
cervical cancer 318
renal cancer 312
cardiovascular disease 281
incontinence 269
hypertension 267
lymphoma 264
SCID 250
non-small cell lung cancer 244
depression 238
recurrent prostate cancer 237
urethra 224
skin cancer 218
liver cancer 208
squamous cell carcinoma 206
hormone refractory prostate cancer 201
hypogonadism 194
testicular cancer 190
glioblastoma 190
liver cancer 186
glioma 186
metabolic syndrome 184
bone disease 180
tumor angiogenesis 180
impotence 172
retinoblastoma 162
anemia 161
solid tumor 157
Hodgkin's disease 156
type 2 diabetes 154
endometrial cancer 150
osteosarcoma 143
neuroblastoma 138
ATM 138
PIN 134
HIV 133
gynecomastia 131
sexual dysfunction 130
spinal cord compression 125
thyroid cancer 122
tumor initiation 120
stroke 119
neutropenia 119
cold 116
Alzheimer's disease 115
lung carcinoma 114
West 111
sarcoma 111
rectal cancer 109
hypercalcemia 109
thrombocytopenia 106
acute myeloid leukemia 106
head and neck cancer 106
aggression 101
EMT 101
Steroids 99
B-cell lymphoma 99
cancer recurrence 98
metastatic breast cancer 97
adenoma 96
lung metastases 96
esophageal cancer 96
residual disease 95
invasive cancer 90
suicide 89
endometriosis 88
Adenocarcinoma 88
lymphadenopathy 87
neoplastic transformation 87
non-Hodgkin's lymphoma 86
esophageal cancer 84
herpes simplex 83
GSH 82
small cell lung cancer 81
Blocking 80
APC 80
myelosuppression 79
atherosclerosis 75
ureter 75
transitional cell carcinoma 73
ductal carcinoma in situ 72
uterus 72
DDP 71
infertility 70
NOD 69
hematologic malignancies 69
proctitis 68
SDS 68
chronic fatigue syndrome 66
confusion 66
infectious diseases 64
measurable disease 63
coronary artery disease 63
dysplasia 60
liver metastases 60
DES 59
chronic myeloid leukemia 59
disseminated intravascular coagulation 58
glioblastoma multiforme 58
influenza 58
heart disease 58
sepsis 58
AIDS 56
SEM 56
cytomegalovirus 55
MTS 55
sepsis 55
cystitis 55
heart failure 55
myocardial infarction 54
Best 54
androgen independent prostate cancer 54
second cancer 53
rheumatoid arthritis 53
stress incontinence 52
chronic lymphocytic leukemia 52
hyperglycemia 52
brain cancer 51
acne 51
WT1 50
systemic disease 50
acute promyelocytic leukemia 50
more...
Symptom
pain 1010
bone pain 289
fatigue 276
diarrhea 143
anesthesia 124
hot flashes 114
nausea 105
hot flushes 85
overweight 81
discomfort 77
dysuria 77
discomfort 70
starvation 63
weakness 58
vomiting 58
headache 53
anorexia 50
back pain 47
dyspnea 46
abdominal pain 43
analgesia 41
pelvic pain 38
prostatism 36
cachexia 36
nausea and vomiting 36
constipation 26
seizures 25
collapse 25
cancer pain 22
low back pain 22
urinary frequency 21
exhaustion 19
Ill 19
chills 19
acidity 17
cough 17
menopausal symptoms 16
erythema 15
masculinization 15
flushing 14
stigma 14
asthenia 14
sleepiness 13
ataxia 13
insomnia 13
dizziness 12
tremor 11
angina 11
numbness 11
myalgia 11
paresis 11
lethargy 10
chest pain 10
hip pain 10
flank pain 9
Lower urinary tract symptoms 8
functional recovery 8
shortness of breath 8
tenesmus 8
arthralgia 8
Acute urinary retention 7
hepatomegaly 7
leg edema 7
mastalgia 6
leg pain 6
Urinary symptoms 6
exertional dyspnea 6
agitation 5
skin irritation 5
fever of unknown origin 5
Wind 5
night sweats 5
oliguria 5
ophthalmoplegia 5
decreased appetite 5
paresthesia 5
paraparesis 5
rectal pain 5
penile lesion 5
blurred vision 5
dysarthria 4
hypothermia 4
respiratory distress 4
HSA 4
Postoperative pain 4
thinning 4
acute pain 4
abdominal fullness 4
Scratch 4
testicular pain 4
dental pain 3
vertigo 3
Visual symptoms 3
frequent urination 3
incoordination 3
rigors 3
Flare 3
Cancer Fatigue 3
eye pain 3
stomach pain 3
cyanosis 3
shoulder pain 3
memory loss 3
hopelessness 3
spasm 3
hoarseness 3
hunger 2
tinnitus 2
GI irritation 2
otalgia 2
apathy 2
tingling 2
physical symptom 2
general problem 2
Anoxia 2
groin pain 2
enuresis 2
muscle cramps 2
hypotonia 2
retching 2
renal colic 2
GU symptoms 2
anal pain 2
nasal congestion 2
neuralgia 2
epigastric pain 2
physical appearance 2
No pain 2
abdominal discomfort 2
pallor 2
acute abdominal pain 2
heartburn 2
Breast pain 2
neck pain 2
hyperoxia 2
sciatica 2
ENT 2
snoring 2
distraction 2
splenomegaly 2
tachypnea 2
syncope 2
hypercapnia 1
pleuritic chest pain 1
Flu-like symptoms 1
tense 1
wheezing 1
syncopal episodes 1
CSR 1
intestinal bleeding 1
Chills and fever 1
Poor sleep 1
BHS 1
emaciation 1
dysesthesia 1
Depressive symptoms 1
testicular lump 1
forgetfulness 1
metamorphopsia 1
lassitude 1
more...
Drug
Docetaxel 326
ETS 278
lysine 245
vitamin E 223
R1881 204
ROS 152
DHT 148
DHT 148
Casodex 143
ROC 130
Zoladex 99
Zoledronic acid 99
Zoladex 92
Zoledronic acid 91
CSF 78
Vitamin E 77
Denosumab 76
ICI 66
Finasteride 66
Estracyt 63
ascorbate 62
IL-2 60
IFN-gamma 60
uPA 56
Estracyt 55
Monit 54
Dihydrotestosterone 53
Taxol 52
Taxotere 51
MAP 50
Estrogens 50
Adriamycin 47
Lupron 47
Luteinizing 45
CTX 43
Dutasteride 42
TAK 39
ACT 38
Provenge 38
Ketoconazole 37
Leaf 36
Paraffin 33
Dermatol 32
Gel 29
EHDP 28
Vitamin A 28
EE2 28
Tocopherol 27
NADH 27
Spectrum 27
Bayer 26
CTX 25
ProstaScint 25
Bortezomib 24
EPI 23
CTX 23
CTC 22
CTC 22
Herceptin 22
Gefitinib 22
Ipilimumab 21
Etoposide 21
caffeine 20
CAM 20
p75 19
KGF 18
Activin 18
Glutathione 18
GEO 18
Asn 17
Imatinib 17
DNase I 17
HCG 17
ABC 16
citric acid 16
Cetrorelix 15
Raloxifene 15
NVP 15
2-Methoxyestradiol 15
Anandron 15
MRC 15
ALA 15
PNT 15
Retinoic acid 14
Simvastatin 14
Mutagen 14
Abarelix 13
Cardiovasc 13
PMPA 13
ADR 13
AraC 12
Dasatinib 12
Alliance 12
Glycyrrhiza 12
ADM 12
SrCl2 12
G-CSF 12
Eulexin 12
Prednisone 12
Epigallocatechin 12
Portal 11
Angiotensin II 11
Kenyan 11
TAT 11
CPT-11 11
Gleevec 11
Bevacizumab 11
PTH 11
Emcyt 11
Lenalidomide 10
Lovastatin 10
Sorafenib 10
ETA 10
Troglitazone 10
Fluorescein 10
Clodronate 10
Satraplatin 10
lactose 10
CCL 9
Nephron 9
Biopolymers 9
EPA 9
CFS 9
Indomethacin 9
Encore 8
Urokinase 8
Triptorelin 8
APD 8
Nephron 8
IFN-beta 8
G418 8
Vinorelbine 8
Serum albumin 8
Albumin 8
Growth hormone 7
NOV 7
Fragment 7
nitroglycerin 7
Orlistat 7
Gelatin 7
Naftopidil 7
Optison 7
Heme 7
Growth hormone 7
Optison 7
ENT 7
Aredia 6
DM1 6
PCB 6
Flavopiridol 6
Genasense 6
Amifostine 6
Vitamin K 6
Orphan 6
Riboflavin 6
Alanine 6
THF 6
Depo-Provera 5
Arsenic trioxide 5
Viagra 5
more...
Enzyme
prostate-specific antigen 4866
prostate-specific membrane antigen 1110
mitogen-activated protein kinase 1029
ERK 964
luciferase 647
caspase-3 586
protein kinase 523
focal adhesion kinase 463
PARP 398
acid phosphatase 293
proteasome 279
alkaline phosphatase 273
protein kinase C 228
urokinase-type plasminogen activator 208
MEK 201
reverse transcriptase 191
ACS 184
kallikrein 177
caspase-9 175
caspase-8 152
phosphatidylinositol 3-kinase 151
glutathione S-transferase 148
AMP-activated protein kinase 136
5alpha-reductase 133
5alpha-reductase 132
cdc2 131
lactate dehydrogenase 103
phosphoinositide 3-kinase 102
ATPase 97
catalase 96
RNA polymerase 93
peroxidase 91
AMPK 91
GSK 88
AMPK 82
topoisomerase 79
trypsin 77
APC 77
MAT 74
MAT 74
topoisomerase 73
superoxide dismutase 72
phosphodiesterase 70
collagenase 70
thymidine kinase 70
MMP 66
calcineurin 66
DNA methyltransferase 66
P-glycoprotein 65
CYP3A4 61
MDP 60
phospholipase C 58
hepsin 55
hepsin 55
IKK 53
RNase 52
RNase 51
alpha-methylacyl-CoA racemase 51
glutathione peroxidase 49
HDR 49
demethylase 48
lipoxygenase 44
beta-galactosidase 41
CD10 40
ornithine decarboxylase 39
thrombin 38
cathepsin B 38
alanine aminotransferase 37
matrix metalloproteinase 9 36
aspartate aminotransferase 36
histone acetyltransferase 36
transcriptase 36
matriptase 35
matrix metalloproteinase 2 35
tissue kallikrein 35
NQO1 35
NADPH oxidase 34
phospholipase A2 33
MAP 33
protein phosphatase 2A 33
matriptase 32
NADPH oxidase 31
UDP-glucuronosyltransferase 31
PDK1 30
histone demethylase 30
renin 29
chymotrypsin 29
HSD 27
plasmin 27
glyceraldehyde-3-phosphate dehydrogenase 27
polo-like kinase 1 26
15-lipoxygenase 26
cathepsin D 25
hyaluronidase 24
firefly luciferase 24
hyaluronidase 22
furin 22
MMP-3 22
ACE 21
chloramphenicol acetyltransferase 21
adenylate cyclase 21
endonuclease 20
caspase-7 20
caspase-7 20
DNA polymerase 19
ribonuclease 19
ribonuclease 19
sulfatase 19
enolase 18
aldehyde dehydrogenase 18
glutathione reductase 18
arginase 18
DNase 18
MDR 18
creatine kinase 18
12-lipoxygenase 17
MIP 17
monoamine oxidase 17
15-hydroxyprostaglandin dehydrogenase 17
CPT 17
glyceraldehyde-3-phosphate dehydrogenase 17
complex I 17
cytosine deaminase 16
aldehyde dehydrogenase 16
aldehyde dehydrogenase 16
thioredoxin reductase 16
kinesin 16
aldehyde dehydrogenase 16
caspase-1 16
granzyme B 16
aldehyde dehydrogenase 16
thymidylate synthase 15
cathepsin K 15
transglutaminase 15
xanthine oxidase 14
N-acetyltransferase 14
choline kinase 14
PDE 14
thromboplastin 14
carboxypeptidase G2 13
acetyl-CoA carboxylase 13
CaMKII 13
acetylcholinesterase 13
lysyl oxidase 13
CD13 13
caspase-2 13
caspase-2 13
proprotein convertase 13
gamma-glutamyl transpeptidase 13
tissue plasminogen activator 12
tyrosinase 12
AST 12
N-acetylglucosaminyltransferase 12
LPL 12
glyceraldehyde-3-phosphate dehydrogenase 11
glyceraldehyde-3-phosphate dehydrogenase 11
NOS 11
CPT 11
peroxiredoxin 11
MEKK1 11
more...
Compound
DNA 4133
Dec 4092
Clin 3978
Androgen 1135
acetate 1007
oxygen 796
calcium 668
MTT 619
water 481
MDA 433
tyrosine 428
vitamin D 422
phosphate 411
serine 388
glucose 372
selenium 365
lysine 358
zinc 302
sodium 289
Docetaxel 289
iodine 245
hydrogen 242
PEG 241
ATP 219
cysteine 218
Testosterone 213
Testosterone 211
His 210
DHT 198
threonine 194
arginine 194
methionine 189
alanine 189
bromide 183
ACS 183
ACS 183
PEG 179
Pac 169
iron 168
TNM 167
leucine 163
retinoic acid 159
Estrogen 156
nitrogen 155
TNF 155
sulfate 151
urea 150
cAMP 125
PIN 122
MEK 122
NH2 118
FTA 116
glutamine 116
ethanol 115
nitric oxide 111
Insulin 108
PAP 104
PAP 104
PAP 104
PAP 103
Genistein 101
Vitamin D 101
copper 100
GSH 98
Curcumin 98
GSH 98
galactose 97
Estrogen 96
creatinine 95
cadmium 95
pyridine 94
strontium 93
Gly 87
Vitamin E 86
glutamate 84
Adriamycin 81
Phe 79
fluorine 79
Estracyt 78
Optimal 78
Bicalutamide 78
Estracyt 78
Lycopene 75
Asp 75
tryptophan 74
dUTP 73
retinol 73
N-acetylcysteine 73
salt 72
PMA 71
25-dihydroxycholecalciferol 69
ADP 69
boron 69
TOF 68
androstane 68
SDS 68
NAD 67
CoA 67
ICI 67
DHA 65
ADP-ribose 65
AMP 62
Resveratrol 62
DES 59
proline 59
Vimentin 58
ADP 57
ADP 57
potassium 56
Histone 56
MTS 55
ADR 53
Neo 52
Choline 52
formaldehyde 51
methanol 51
5-FU 50
NAD 49
silver 49
CAM 49
ASA 49
Paclitaxel 48
H2O2 47
TEM 46
DDP 45
acridine 45
Metformin 45
THP 45
Estramustine 45
Metformin 45
COS 44
THP 44
CTX 43
tryptophan 43
hyaluronic acid 42
GTP 42
Ile 42
MAP 42
indole-3-carbinol 41
valine 41
nicotinamide 41
tryptophan 41
tryptophan 41
Silymarin 41
VP-16 40
CCC 40
silicon 40
NADPH 39
NADPH 39
pentanedioic acid 39
Cholesterol 39
PGE2 38
pyrimidine 37
acetic acid 37
PGE 37
Sulforaphane 37
Ketoconazole 37
Melatonin 36
Leuprolide 36
chalcone 35
more...