Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0376358 (
prostate cancer
)
59,338
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kinesin family member C1
(
KIFC1
) is a minus end-directed motor protein that plays an essential role in centrosome clustering. Previously, we reported that
KIFC1
is involved in cancer progression in
prostate cancer
(PCa). We designed this study to assess the involvement of
KIFC1
in docetaxel (DTX) resistance in PCa and examined the effect of
KIFC1
on DTX resistance. We also analyzed the possible role of a
KIFC1
inhibitor (CW069) in PCa. We used DTX-resistant PCa cell lines in DU145 and C4-2 cells to analyze the effect of
KIFC1
on DTX resistance in PCa. Western blotting showed that
KIFC1
expression was higher in the DTX-resistant cell lines than in the parental cell lines. Downregulation of
KIFC1
re-sensitized the DTX-resistant cell lines to DTX treatment. CW069 treatment suppressed cell viability in both parental and DTX-resistant cell lines. DTX alone had little effect on cell viability in the DTX-resistant cells. However, the combination of DTX and CW069 significantly reduced cell viability in the DTX-resistant cells, indicating that CW069 re-sensitized the DTX-resistant cell lines to DTX treatment. These results suggest that a combination of CW069 and DTX could be a potential strategy to overcome DTX resistance.
...
PMID:KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer. 3074 26
