Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0376358 (
prostate cancer
)
59,338
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Genomic changes affecting tumour suppressor genes are fundamental to cancer. We applied SNP array analysis to a panel of testicular germ cell tumours to search for novel tumour suppressor genes and identified a frequent small deletion on 6q25.3 affecting just one gene,
ZDHHC14
. The expression of
ZDHHC14
, a putative protein palmitoyltransferase with unknown cellular function, was decreased at both RNA and protein levels in testicular germ cell tumours.
ZDHHC14
expression was also significantly decreased in a panel of
prostate cancer
samples and cell lines. In addition to our findings of genetic and protein expression changes in clinical samples, inducible overexpression of
ZDHHC14
led to reduced cell viability and increased apoptosis through the classic caspase-dependent apoptotic pathway and heterozygous knockout of
ZDHHC14
increased [CORRECTED] cell colony formation ability. Finally, we confirmed our in vitro findings of the tumour suppressor role of
ZDHHC14
in a mouse xenograft model, showing that overexpression of
ZDHHC14
inhibits tumourigenesis. Thus, we have identified a novel tumour suppressor gene that is commonly down-regulated in testicular germ cell tumours and
prostate cancer
, as well as given insight into the cellular functional role of
ZDHHC14
, a potential protein palmitoyltransferase that may play a key protective role in cancer.
...
PMID:Identification of ZDHHC14 as a novel human tumour suppressor gene. 2461 51
