Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0376358 (prostate cancer)
 59,338 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 54-year-old man who had been administered chlormadinone acetate 3 months after prostatectomy for prostate cancer, acutely developed disorientation and memory disturbance. Six days later, he experienced high grade fever and epigastralgia. He was suspected to have hepatic encephalopathy, because the Fischer ratio was low although serum ammonia level remained normal. Further examinations including abdominal echography and CT scan disclosed a thrombus extending from the portal vein to the superior mesenteric vein together with abnormal collateral vessels originating from the portal vein. He was successfully treated with warfarin potassium, urokinase and heparin sodium. It was suggested that the patient developed hepatic encephalopathy due to portal-systemic circulation shunting secondary to portal vein thrombosis.
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PMID:[Portal vein thrombosis associated with hepatic encephalopathy]. 1583 95

A 58-year-old man visited our hospital with a chief complaint of epigastric pain. Computed tomography of the abdomen revealed a tumor in the left lobe of the liver accompanied by portal vein tumor thrombus, and Vp3 hepatocellular carcinoma was diagnosed. Prostate cancer with multiple bone metastases was also identified, and synchronous double cancer of the prostate and liver was diagnosed. The treatment strategy was to prioritize surgery for the hepatocellular carcinoma, for which curative resection was becomingnearly impossible. Left hepatic lobectomy was performed, and the postoperative course was favorable. Combined androgen blockade(CAB)with leuprorelin acetate and bicalutamide performed to treat the prostate cancer produced a significant decline in prostate-specific antigen(PSA)levels, causingthe metastatic bone lesions to disappear and relievingsymptoms. The patient has experienced no recurrence of hepatocellular carcinoma for 2 years 6 months since the initial treatment, and PSA levels have remained below the limits of detection. Few reports have described synchronous double cancer of the prostate and liver. In the present case, both cancers were advanced, but multimodal therapy combiningsurg ery(local treatment)and hormone therapy(systemic treatment)performed in accordance with the respective disease stages produced favorable results.
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PMID:[A Case of Synchronous Vp3 Hepatocellular Carcinoma and Prostate Cancer Accompanied by Bone Metastases]. 2813 35