Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0376358 (prostate cancer)
 59,338 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of orbital metastasis from Whitmore stage D adenocarcinoma of the prostate is described. Clinically, it presented as rapidly progressing exophthalmos of the right eye with elevation (ptosis) and abduction paralysis. The associated clinical picture of a one-year history of prostatism prompted patient referral to our department. When a patient presents with an orbital tumor and a history of cancer localized to another site, the metastatic origin of the condition should be suspected and metastasis to other sites sought. A negative finding warrants performing orbital biopsy to confirm the diagnosis. Although excision of single metastatic tumors in this site has been described, coexisting metastasis to bone and lymph nodes, the hormone dependence that these present and prostatic cancer contraindicate resection of the orbital metastatic tumor. Following bilateral orchiectomy and hormone therapy with antiandrogens micturitional symptomatology improved, tumor size was reduced, and exophthalmos disappeared. The case described herein is not the first case of this type of metastatic lesion reported in the literature; 28 cases have been reported to date. This uncommon clinical presentation with extraurological manifestations gives us an idea of the broad clinical spectrum the biological behaviour of this tumor type can adopt.
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PMID:[Exophthalmos caused by orbital metastasis of prostatic carcinoma]. 171 62

A 72-year-old man was admitted to our hospital complaining of diplopia and right exophthalmos. Craniography and CT scan showed thickening of the right orbital roof and no intracranial lesion. Total acid phosphatase and prostatic acid phosphatase were high. Bone scintigraphy revealed high uptake at that lesion and the right pelvis. Unroofing of the right orbit and opening of the optic canal were performed in order to reduce intraorbital pressure. Microscopic examination revealed a metastatic lesion of prostatic cancer. Postoperatively, the patient was treated with "Honvan" and the course has been good.
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PMID:[Skull base metastasis of prostatic cancer presenting as exophthalmos--a case report]. 399 93

Orbital metastasis is an unusual localization within tumoral dissemination of prostatic cancer. Similarly, it is rare that orbital metastasis might be responsible for the clinic manifestations that determine the initial diagnosis of neoplasia. We illustrate the case of a patient suffering from prostatic adernocarcinoma that displayed alterations of facial sensitivity and right eye exophthalmos. We describe how the final diagnosis was reached and the patient's response to the suppressive hormonal treatment. The patient's rate of survival has proved to be longer than the rest of cases documented, with over 30-month follow-up.
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PMID:[Retrorbital metastasis an initial manifestation of prostatic cancer]. 1293 90

Prostate cancer is frequently complicated by bone metastases. However some metastatic sites remain rare and unusual. The authors report an exceptional case of prostatic carcinoma presenting with orbital metastasis. A 71-year-old man was admitted with ocular protrusion and decreased visual acuity of the left eye. In addition to the ophthalmological disorders, clinical examination revealed a left temporoparietal swelling with a suspicious prostate on digital rectal examination. Brain MRI revealed an osteolytic process involving the left sphenoid bone with intra-orbital invasion. Another osteolytic site was observed in the left temporoparietal region with intracranial and extracranial components. PSA was 13,327 ng/ml. Prostatic biopsy confirmed the diagnosis of prostatic carcinoma. Treatment comprised cranial radiotherapy combined with anti-androgen endocrine therapy and corticosteroids. Six weeks after treatment, the patient obtained an improvement of visual acuity and regression of exophthalmos and the temporoparietal swelling. Orbital metastasis of prostatic carcinoma raises the problem of ophthalmic emergency. Cranial radiotherapy and anti-androgen endocrine therapy allowed regression of the symptoms without modifying the unfavourable course of the disease.
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PMID:[Orbital metastasis of prostatic carcinoma]. 1582 1

The case of a 66-year-old gentleman who presented with unilateral proptosis, eye pain and partial loss of vision seven years after his original prostate cancer diagnosis is reported. MRI of the orbits revealed a 2-cm lesion in the posterolateral right orbital wall near the optic foramen with compression of the optic nerve. Metastatic orbital lesions are relatively uncommon in prostate cancer. Treatment is palliative and varies according to the time of presentation in the course of the disease. This patient's symptoms resolved after reinitiation of combined androgen blockade.
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PMID:Proptosis and decreased vision secondary to prostate cancer orbital wall metastasis. 1610 Nov 73

Orbital metastasis caused by prostate cancer is rare. We report a case of prostate cancer diagnosed from the initial ocular signs with complaints of decreased vision and exophthalmos. The orbital tumor was surgically removed and endocrine therapy was performed subsequently. Metastatic carcinoma of the prostate should be considered in the elderly male with exophthalmos.
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PMID:A case of orbital metastasis from prostatic carcinoma as an initial symptom. 1744 92

We report the case of a man with advanced prostate cancer who presented as an emergency with proptosis of his right eye. Cross-sectional imaging of his head confirmed the cause to be orbital metastases secondary to his prostate cancer. The patient responded well to treatment with dexamethasone and palliative orbital radiotherapy.
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PMID:Proptosis--an uncommon presentation of orbital metastases secondary to prostate cancer. 1802 61

Prostate carcinoma, when metastatic, typically involves bone and produces both osteoblastic and osteolytic changes. Orbital involvement is uncommon and extraocular muscle enlargement is a rare presentation of metastatic prostate adenocarcinoma. The authors present 2 patients with prostatic tumor metastasis to extraocular muscles. One patient had single-muscle involvement; the other presented with bilateral progressive proptosis, upper eyelid retraction, and bilateral multiple extraocular muscle enlargement mimicking thyroid-associated orbitopathy. Clinicians should be aware that, although rare, prostate cancer can involve the extraocular muscles.
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PMID:Prostate carcinoma metastasis to extraocular muscles. 1852 Aug 46

Prostate cancer, when metastatic, typically involves the axial skeleton. Sphenoidal metastasis is uncommon. We report a rare case of a 75-year-old man who presented with isolated unilateral exophthalmos. Digital rectal examination and serum prostate-specific antigen level were suggestive of metastatic prostate cancer. The prostate biopsy and imaging findings confirmed the source of the exophthalmos as a sphenoidal metastasis of an aggressive prostate adenocarcinoma.
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PMID:Unilateral exophthalmos revealing metastatic prostate cancer. 2224 96

Metastases to the eye or orbit as the initial presentation of genitourinary malignancy are unusual and can be a diagnostic challenge. We report an 81-year-old man who presented with pain and proptosis in an eye that had been blind for 50 years. Radiologic investigations identified a mass involving the left globe and orbit. Histology of the enucleation specimen was consistent with a metastatic poorly differentiated carcinoma suggestive of a prostate primary. With the constellation of obstructive urinary symptoms, an abnormal digital rectal examination, elevated prostate-specific antigen and a positive bone scan, androgen deprivation therapy was initiated for metastatic prostate cancer. After an initial response to treatment, the patient's disease progressed in a manner atypical for prostate cancer. After describing our case, we review the literature on ocular and orbital metastases and their relation to genitourinary malignancies.
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PMID:Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature. 2251 37


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