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Query: UMLS:C0376358 (prostate cancer)
 59,338 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Most humans in the United States have been infected with BK virus (BKV), a human papovavirus. Because BKV has oncogenic properties, we have investigated whether it may be a cause of human cancer. Basic principles of tumor virology imply that BKV-induced tumors should contain BKV DNA sequences. Therefore, we assayed (by molecular hybridization) DNA from human tumors and malignant cell lines for BKV DNA, using BKV [(32)P]DNA as probe. The BKV [(32)P]DNA was labeled in vitro (nick translation) to specific activities of 1 to 2 x 10(8) cpm/mug. The BKV DNA used to prepare our probes had the properties expected of authentic BKV genomes, including density of superhelical DNA, sedimentation velocity in alkaline and neutral sucrose gradients, production of one fragment by endonuclease EcoRI cleavage and four fragments by endonuclease Hin II + III cleavage and reassociation properties. From these studies we conclude that our BKV probes hybridized well, and represented bona fide BKV DNA. Using three different BKV [(32)P]DNA probes, i.e., from three distinct plaque isolates, we have analyzed DNA from BKV-transformed cells, normal human tissues, and a large number of human tumors. All human DNAs (cell lines, normal tissues, tumors) hybridized 5% with BKV DNA. Hybridization analysis of BKV-transformed hamster cell DNA indicated 5-6 copies of at least 88% of the BKV genome per cell. No BKV DNA sequences were detected (above the normal 5% hybridization to all human DNAs) in the following normal human tissues: 10 kidney (BKV is usually isolated from urine), 3 spleen, 13 lung, 23 colon, 2 rectum, 1 ileum, and 1 skin. No BKV-specific DNA was found in 166 tumors, including 5 carcinomas (Ca) of stomach, 3 Ca small intestine, 26 Ca colon, 9 Ca rectum, 31 Ca lung, 9 adenocarcinomas and 5 oat cell carcinomas of lung, 17 melanomas, 5 Ca prostate, 4 Ca bladder, 6 Wilms tumors, 4 hypernephromas, 15 Ca kidney, 7 brain tumors, 5 Hodgkin lymphomas, 10 lymphomas (immunosuppressed patients have a high incidence of lymphomas), 2 reticulum cell sarcomas (spleen), and 3 skin tumors. We have also analyzed 7 human malignant cell lines (melanoma, lung, rhabdomyosarcoma, and glioblastomas), including several clones of a lung melanoma line; no BKV DNA sequences were detected. Because our probes could detect one copy of BKV DNA if only 10% of the cells were tumor cells, our results are very strong evidence that the tumors we analyzed did not have a BKV etiology. The tumors we tested represent about 50% of all cancers in the United States; there is no evidence that BKV is involved in the etiology of these types of tumors.
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PMID:Analysis of human tumors and human malignant cell lines for BK virus-specific DNA sequences. 20 40

From the Third National Cancer Survey (TNCS) Interview Study of 7,518 incident cases, lifetime histories of occupations and industries were studied for associations with specific cancer sites and types while controlling for age, sex, race, education, use of cigarettes or alcohol, and geographic location. Lung cancer patients were found more often than expected among several categories including trucking, air transportation, wholesaling, painting, building construction, building maintenance, and manufacturing (furniture, transportation equipment, and food products). Controlling for cigarette smoking did not change these associations. Leukemia and multiple myeloma were associated with sales personnel of both sexes, whereas lymphomas and Hodgkin's disease were excessive among women working in the medical industry. Other associations included rectal cancer with several retail industries; prostate cancer with ministers, farmers, plumbers, and coal miners; malignant melanoma with school teachers; and invasive cervical cancer with women working in hotels and restaurants. Breast cancer patients were more common among women who were teachers or other professionals and who worked in business and finance (even after controlling for education). Many other findings are presented in detailed tables. Results are reported mainly as a research resource for use by other investigators doing work in this field. Suggestions are given for future studies.
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PMID:Associations of cancer site and type with occupation and industry from the Third National Cancer Survey Interview. 90 93

A study was made of the potentialities of lymphography using a new radiopaque medium chromethiotrast (a solution of harmless fat-soluble anthraquinone dyes fixed with ethiotrast). The agent is intended for combined x-ray and visual investigation of the lymphatic system. Lymphograms of 76 patients (with Hodgkin's disease, prostatic cancer, cancer of the female organs, breast, bladder, rectal cancer, and secondary limb lymphedema) were analyzed. Chromethiotrast is easily administered in the lymphatic bed ensuring a good contrast density of the lymphatic vessels permitting the detection of their structure. Chromethiotrast is quickly discharged from the lymphatic system, causing no marked side-effects provided all precautions necessary for the administration of iodobutyric radiopaque media, are taken.
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PMID:[Potentialities of lymphography using chromethiotrast, a new x-ray contrast medium]. 145 58

Metastatic cancer to the penis is rare, its optimum treatment remains poorly defined and the outcome of patients with such metastases is poor. Hyperthermia in conjunction with radiation therapy has been shown to be an effective modality in the treatment of locally advanced or recurrent cancer and hyperthermia alone is under evaluation in treating benign disorders, such as hypertrophy of the prostate. Recently, 4 patients with symptomatic metastatic lesions to the penis (3 had primary prostatic cancer and 1 had rectal cancer) were treated with radiation therapy and hyperthermia. Treatment was well tolerated except for pain during hyperthermia, which limited the temperatures that could be obtained. All of the patients improved symptomatically, 1 achieved a complete response and 2 had partial responses. No significant complications were noted. Symptomatic control was maintained in all patients for the duration of their survival. This limited series suggests the possible role of local hyperthermia as an adjunct to radiation therapy in the treatment of metastases to the penis.
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PMID:Cancer metastatic to the penis: treatment with hyperthermia and radiation therapy and review of the literature. 161 85

Migration of Italians to other parts of the world has a long history and has involved very large numbers of individuals. The study of the health consequences of this migration is made possible by the availability of statistics on mortality and morbidity, both in Italy and in the host countries, and of social and economic information on the various Italian communities abroad. The results of the major studies are reviewed, comparing the rates in immigrants with those in the host countries and in Italy. The differences in cancer rates between Italian and local-born populations--for stomach cancer in both sexes, and for cancer of the colon, lung, and breast in females, and for prostate cancer--are consistent with the direction of differences between rates in Italy and those in the host countries. For colon and rectum cancer in males, there are unexpected findings in most of the United States' studies. Analysis by duration of residence shows changes in the risk for several sites in males, but not in females, according to length of stay in the host country. This finding possibly reflects greater stability of habits and lifestyle in females compared to males.
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PMID:Cancer in Italian migrants. 187 37

The incidence, predisposing factors, localization, evolution and outcome of neoplasms following kidney transplantation were studied in two groups of patients--120 and 146 patients for an observation period from 1 to 16 years. In patients with adequate renal function who received immunosuppressive treatment for more than one year (accordingly 78 and 88 patients) neoplasms developed in 4 and 10 patients with mean duration of immunosuppressive treatment 4.9 and 6.1 years respectively. The neoplasms were: 3 skin cancers, 2 lung cancers, 2 Kaposi sarcomas, 1 lymphosarcoma, 1 breast cancer, 1 prostate cancer, 1 renal cancer, 1 rectal cancer and 2 polyps of the colon. The case fatality rate was 3.6 per cent. The importance of precision of the immunosuppressive treatment for reducing the incidence of these complications is pointed out.
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PMID:[Neoplasms following kidney transplantation]. 194 1

Incidence rates of cancers of the colon, rectum, female breast, and prostate were compared among native Chinese (Shanghai), Chinese-American, and American populations. Americans had fourfold higher age-adjusted rates of colon cancer, and twofold higher rates of rectal cancer than Chinese, which is consistent with elevated per capita intake of fat and lower intake of cereals and vegetables in the US. Incidence rates of colon and rectal cancers in Chinese-Americans were nearly equal to the American rates, suggesting that the risk for tumour development in the lower intestinal tract is rapidly increased with transition to the US diet. Rates of prostate cancer and postmenopausal breast cancer were 26-fold and tenfold higher in Americans than in Chinese, whereas the rates for Chinese-Americans were intermediate. Environmental factors such as dietary fat apparently had a more gradual effect in promoting cancers of the breast and prostate relative to their influence on neoplasms of the lower intestinal tract.
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PMID:Comparative epidemiology of cancers of the colon, rectum, prostate and breast in Shanghai, China versus the United States. 206 47

Rectal invasion in prostate cancer is an uncommon clinical finding to which little attention has been focussed in the literature. However, it can represent important clinical (rectorrhagia, tenesmus and obstruction), diagnostic (confused with rectal cancer) and therapeutic problems. We report two cases of prostatic carcinoma with rectal invasion, one at the time of presentation and the other during the course of the disease, that illustrate the problems associated with this form of neoplastic spread.
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PMID:[Cancer of the prostate with rectal invasion]. 209 33

A retrospective cohort study was undertaken to examine the cancer morbidity in a group of 759 furniture makers of the Neubrandenburg District. During the study interval of 1973 to 1984, a total of 40 malignant tumors occurred in the exposed group. Except for bronchial cancer (SIR = 68) and prostate cancer (SIR = 43), all observed tumors were overrepresented in comparison to the incidence of such illnesses in the normal population of the study area. Significantly increased SIRs occurred for malignant melanoma (2 cases, SIR = 952) and for rectal cancer (6 cases, SIR = 239). Malignant tumors of the nose and paranasal sinuses were not observed.
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PMID:Retrospective cohort study of cancer morbidity in furniture makers exposed to wood dust. 275 Feb 37

Data from the national tumor registry of Costa Rica for the years 1979-1983 have been used to calculate incidence rates for the major cancer sites by age, sex, urban-rural residence, and geographic region. Recent trends in mortality rates are also presented. Results are compared with data from elsewhere in Latin America, U.S.A., Europe, and Japan. Stomach cancer is the most frequent neoplasm in Costa Rica; although rates are declining, they are second only to those observed in Japan. There are marked variations in risk by region, suggesting important environmental influences in etiology. The cervix is the major female site; rates are declining in young women, probably due to the introduction of screening programs, although these do not seem to account for the geographic variations in invasive cancer incidence. Breast and prostate cancer show moderate rates, while those for colon and rectum cancer are low; increases in mortality rates for these sites are small, and involve mainly the older age groups. In contrast, rates of lung cancer are increasing dramatically in both sexes. In the childhood age group, very high incidence rates are observed for two neoplasms: Hodgkin's disease and acute lymphocytic leukemia.
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PMID:Cancer in Costa Rica. 291 Apr 91


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