Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0349506 (photosensitivity)
 4,145 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A nonsteroidal anti-inflammatory drug suprofen acted as a photosensitizer to oxidize lipids on ultraviolet A irradiation, that is, squalene and cholesterol in ethanol solution and phosphatidylcholine in liposome membranes. Photo-oxidation of squalene sensitized with suprofen was not repressed by the addition of sodium azide. Photo-oxidation of cholesterol sensitized with suprofen produced 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. These findings are consistent with the type I mechanism but not the type II mechanism of photo-oxidation. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increased leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. These results suggest that the photo-oxidation ability of suprofen by the type I mechanism is a possible key to the induction of suprofen photosensitivity.
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PMID:Type I lipid photo-oxidation by the nonsteroidal anti-inflammatory drug suprofen: a possible key to its photosensitivity. 134 89