Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0348321 (
Haemophilus
)
15,372
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Nontypeable
Haemophilus
influenzae (NTHi) is a common cause of respiratory tract infections. This study investigated the ability of NTHi to bind
lipopolysaccharide-binding protein
(
LBP
) derived from respiratory epithelial cells and the subsequent stimulation of transfected cells expressing membrane-bound CD14 and toll-like receptor 2 (TLR2) or TLR4. In the absence of
LBP
, NTHi at high concentrations (100 bacteria/epithelial cell) were required to induce signals through TLR2 and TLR4. Flow cytometry showed that NTHi in the stationary phase bound more
LBP
than did log-phase bacteria. Of interest, as few as 1
LBP
-bearing bacterium/cell induced strong signaling through TLR4. In contrast,
LBP
bound to NTHi did not promote any increased signaling mediated by TLR2, compared with NTHi without
LBP
. These data suggest that, upon NTHi infection, low numbers of bacteria binding
LBP
may activate TLR4-bearing cells, such as alveolar macrophages, and consequently induce an inflammatory response.
...
PMID:Lipopolysaccharide-binding protein increases toll-like receptor 4-dependent activation by nontypeable Haemophilus influenzae. 1152 97
