Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recruit sick call at the Naval Training Center, Great Lakes, Illinois was monitored for cases of conjunctivitis during two 2-week periods in March in 1981 and 1982. Twenty-three cases were detected. The incidence of conjunctivitis was 1.1 cases per 1000 recruits per week. Peak incidence occurred during the third and fourth weeks of training and two recruit companies had multiple cases. Conjunctival cultures for viruses and Chlamydia trachomatis were negative in all cases. Concurrent cultures of conjunctival exudate were obtained from 12 cases. Haemophilus influenzae was isolated from three of these cases and Streptococcus pneumoniae from one. Despite the high percentage of negative cultures, the clinical characteristics and pattern of occurrence of conjunctivitis in Navy recruits suggest that it is caused by an infectious agent or agents.
Mil Med 1990 Jan
PMID:Incidence and etiology of conjunctivitis in Navy recruits. 210 32

The first licensed Haemophilus influenzae type B (Hib) vaccines were of a purified capsular oligosaccharide. Unfortunately, oligosaccharides are poorly immunogenic in younger children and resulted in these vaccines not routinely being used until past the period of peak incidence of Hib disease. Subsequent Hib vaccine research revealed that conjugating the oligosaccharide with various carrier proteins could produce vaccines with varying degree of improved immunogenicity. We investigated the antibody response and side effects of HibTITTER, one such vaccine, in 96 young infants in our multi-ethnic, border population. A three-dose course was given concomitantly with DPT and OPV vaccines at 2, 4, and 6 months of age. Seventy-nine percent of the infants had obtained antibody levels reportedly associated with clinical immunity after the second vaccination and 96% after the third vaccination. There was no significant difference in response due to sex, race, or vaccine lot. Currently HibTITER is recommended for use at 18 months of age. Our data strongly suggest that it may be effectively used much earlier, thereby immunizing infants against Hib disease before they reach their age of greatest vulnerability.
Mil Med 1990 Oct
PMID:Three-dose vaccination of infants under 8 months of age with a conjugate Haemophilus influenzae type B vaccine. 212 90

Side-effects and immunogenicity of the Haemophilus influenzae type B polysaccharide vaccine (Hbpv) were reported following introduction in a multi-ethnic border population of 2- to 6-year-old U.S. military dependents. Eighty percent of 659 vaccinees were reported by parents to have no reactions within 48 hours following vaccination; 20% were reported to have local and/or systemic reactions. Each reaction was reported with one-fifth or less the frequency previously reported following DPT vaccination. Serologic data are presented on 114 of the vaccinees. The frequency of pre-vaccination levels reportedly associated with immunity ranged from a lower than expected 54% of 2-year-olds to an expected 86% of 5-year-olds. Post-vaccination levels reportedly associated with immunity ranged from a lower than expected 80% of 2-year-olds to an expected 93% of 5-year-olds. Of the 114 vaccines with serologic data, those with side-effects had serologic changes comparable to those without side-effects. There was no difference in side-effects or immunologic response across ethnic groups. Therefore, side-effects, immunologic responses, and ethnic group appear to be independent variables.
Mil Med 1989 Jan
PMID:Side-effects and immunogenicity of Haemophilus influenzae type B polysaccharide vaccine in a multiethnic pediatric population. 249 1

Lower respiratory disease is a major source of morbidity in military recruits, with hospitalization rates for pneumonia more than 30 times that of the non-recruit population. The etiologic agent remains unknown in over 75% of cases. This study prospectively examined the etiology of pneumonia among recruits at Naval Training Center, San Diego, California. Recruits presenting with cough, fever, or shortness of breath and pulmonary infiltrates on chest X-ray were eligible for enrollment. A standardized scoring form and focused physical exam were completed on each subject. Sputum specimens were obtained for Gram's stain and culture, DNA probing for Legionella and Mycoplasma species, and direct fluorescent antibody staining for Legionella. Acute and convalescent serologies were performed for adenovirus, influenza A and B, Mycoplasma pneumoniae, Chlamydia group, and respiratory syncytial virus. Of 110 eligible patients, 100 consented to enrollment and 75 patients completed the study. Etiologic diagnoses were obtained in 40 of the patients (53%). M. pneumoniae, Haemophilus influenzae, and viruses accounted for the majority of infections. Mixed infections were seen in six patients. Forty-seven percent of patients had no diagnosis established. Pneumonia in this series of military recruits was frequently caused by M. pneumoniae and H. influenzae. Fifty percent of cases were undiagnosed with routinely available laboratory methods. Further studies are warranted to more clearly define the etiologic agents of recruit pneumonia and the utility of prophylactic measures.
Mil Med 1994 Oct
PMID:Pneumonia in military recruits. 787 Mar 17

In 1992, Forces Command had 42 Child Development Centers on 22 installations. We evaluated program compliance in the areas of health, sanitation, and nutrition using inspection findings from April 1991 through June 1992. Each program was rated on 20 items, using inspection checklists developed for this evaluation. We also surveyed Haemophilus influenza type b (Hib) vaccination records among enrolled children. Most programs and facilities were fully or partially compliant in most areas. By quantifying the inspection findings, we were able to identify compliance items that needed further attention. The most frequent problem area across all programs was documentation of child immunization and health records. For children between 13 and 60 months of age, 77.7% had records indicating appropriate vaccination against Hib. Comparisons with the prior year's findings indicated a trend toward improvement.
Mil Med 1994 Mar
PMID:Evaluation of health, sanitation, and nutrition in Forces Command Child Development Centers. 804 68

The immunization status of active duty pediatric dependents served by the National Naval Medical Center was surveyed to estimate the degree to which this group was in compliance with immunization requirements. Four hundred sixteen patients who presented consecutively to a pediatric acute care clinic had their medical and immunization records screened. Ten percent of patients did not have complete records of immunization. Of the 375 patients remaining, 52 (13.9%) were deficient in one or more required immunizations based on their current age. The highest rates of delay were seen for the Haemophilus influenza vaccine followed by measles, mumps, rubella, and diphtheria, tetanus, and pertussis. The most common reason for missing immunizations was parental unfamiliarity with the recommended schedule. This study suggests that a significant number of dependents in our catchment area were delayed in immunization and that accurate record keeping and patient education about immunizations needs to be improved.
Mil Med 1993 Jun
PMID:Immunization status of a military dependent population. 836 91

Concern about emerging and reemerging respiratory pathogens prompted the development of a respiratory disease reference laboratory at the Naval Health Research Center. Professionals working in this laboratory have instituted population-based surveillance for pathogens that affect military trainees and responded to threats of increased respiratory disease among high-risk military groups. Capabilities of this laboratory that are unique within the Department of Defense include adenovirus testing by viral shell culture and microneutralization serotyping, influenza culture and hemagglutination inhibition serotyping, and other special testing for Streptococcus pneumoniae, Streptococcus pyogenes, Mycoplasma pneumonia, and Chlamydia pneumoniae. Projected capabilities of this laboratory include more advanced testing for these pathogens and testing for other emerging pathogens, including Bordetella pertussis, Legionella pneumoniae, and Haemophilus influenzae type B. Such capabilities make the laboratory a valuable resource for military public health.
Mil Med 2000 Jul
PMID:The Naval Health Research Center Respiratory Disease Laboratory. 1092 Jun 35

Vaccines against Haemophilus influenzae type B (HI) and Streptococcus pneumoniae (SP) have dramatically reduced the incidence of bacterial meningitis (due to both HI and SP) and epiglottitis (due to HI) in childhood. The effects of these vaccines on other conditions, however, are less clear. We report an analysis of the effect of serial deployment of various HI and SP vaccines over a 25-year period, involving an examination of over half a million pediatric hospitalizations occurring in Army hospitals worldwide. We show that, in marked contrast to the reduction in the number of meningitis and epiglottitis cases, the disease burden of orbital and facial cellulitis--conditions oft attributed to HI and SP-did not diminish.
Mil Med 2008 Oct
PMID:Immunization against Haemophilus influenzae type B fails to prevent orbital and facial cellulitis: results of a 25-year study among military children. 1916 Jun 9

Laboratory-based surveillance for diarrheal and respiratory illness was conducted at the 2009 Republic of the Philippines-United States Balikatan exercise to determine the presence of specific pathogens endemic in the locations where the military exercises were conducted. Ten stool and 6 respiratory specimens were obtained from individuals meeting case definitions for diarrhea or respiratory illness. Stool specimens were frozen in dry ice and remotely tested using enzyme-linked immunosorbent assay for Rotavirus, Astrovirus, Adenovirus, Entamoeba histolytica, Giardia, and Cryptosporidium and polymerase chain reaction for enterotoxigenic Escherichia coli, Campylobacter, Shigella, Vibrio, Salmonella, and Norovirus. Eight (4 for Campylobacter jejuni, 2 for Campylobacter coli, 1 for Norovirus genogroup II, and 1 for both Campylobacter coli and enterotoxigenic Escherichia coli) of 10 samples were positive for at least 1 enteric pathogen. MassTag polymerase chain reaction for influenza A and B, respiratory syncytial virus groups A and B, human coronavirus-229E and human coronavirus-OC43, human metapneumovirus, enterovirus, human parainfluenza viruses 2,3, and 4a, human adenovirus, Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae, Legionella pneumonia, and Mycoplasma pneumonia was done on respiratory specimens. Out of 6 samples, 3 tested positive for H. influenzae; 1 tested positive for both H. influenzae and human parainfluenza virus 3; and 2 tested negative. Laboratory-based surveillance can be useful in determining etiologies of diarrheal and respiratory illness of deployed military personnel.
Mil Med 2011 Oct
PMID:Applications of PCR (real-time and MassTag) and enzyme-linked immunosorbent assay in diagnosis of respiratory infections and diarrheal illness among deployed U.S. military personnel during exercise Balikatan 2009, Philippines. 2212 41