Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0348321 (
Haemophilus
)
15,372
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cells of wild-type
Haemophilus
influenzae and of a mismatch-repair-deficient mutant (hex-) were grown in a chemically defined medium containing either thymidine or 5-bromodeoxyuridine (
BUdR
). Spontaneous mutation frequencies to resistance against 3 antibiotics observed for the thymidine cultures were 10-30 times higher for the hex- mutant. The mutation frequencies observed for the
BUdR
hex- culture were increased by another 10 times while those for the wild-type suspension did not differ from the frequencies seen in the thymidine medium.
...
PMID:Bromouracil-induced mutagenesis in a mismatch-repair-deficient strain of Haemophilus influenzae. 697 85
