Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rarely is endocarditis attributed to the species of Hemophilus. Most frequently implicated are H aphrophilus and H parainfluenzae, but H influenzae also is seen. We report six cases of endocarditis due to H aphrophilus or H parainfluenzae and review the literature. Emboli to skin, lungs, kidneys, spleen, brain, and other organs are common complications, and acute glomerulonephritis and meningitis often occur. Ampicillin is the mainstay of antimicrobial therapy for patients whose isolates are sensitive to it, but the duration of antimicrobial therapy necessary for eradication of the infection is not clear. Studies of antimicrobial synergism are warranted in instances of endocarditis caused by ampicilin- or penicillin-resistant strains of Hemophilus, or when patients are allergic to penicillin; in these instances, combination antimicrobial therapy must be given when bactericidal synergism can be demonstrated. Intensive management of complications caused by embolization is crucial to patient survival.
South Med J 1977 Sep
PMID:Hemophilus endocarditis: new cases, literature review and recommendations for management. 30 87

The capillary beta-lactamase test for the detection of Haemophilus influenzae resistance to ampicillin was evaluated against 132 strains of H. influenzae recently isolated from clinical materials and four reference strains. Nineteen strains, including two of serotype b, were beta-lactamase-positive. The minimal inhibitory concentrations (MIC) of ampicillin for the 117 beta-lactamase-negative strains ranged from less than or equal to 0.125 to 2 microgram/ml (only one strain had a MIC of 2 microgram/ml). The range of MIC's of ampicillin was 4 to 64 microgram/ml for the 19 beta-lactamase-positive strains; all but two strains required 8 microgram/ml or more for inhibition. The capillary beta-lactamase test is an easy, rapid and reliable test for the detection of H. influenzae resistance to ampicillin. It is suitable for routine use in the clinical microbiology laboratory. The MIC of carbenicillin was higher for ampicillin-resistant than for ampicillin-susceptible strains, but the highest MIC (32 microgram/ml) was within achievable serum concentrations. Both cefamandole and chloramphenicol were active against all strains.
Am J Clin Pathol 1977 Sep
PMID:Evaluation of the capillary beta-lactamase test and antimicrobial susceptibility of Haemophilus influenzae. 30 42

Described herein are three patients over the age of 50 years who had cellulitis of the neck and the upper portion of the chest, associated with Hemophilus influenzae type B bacteremia and respiratory tract infection--particularly that of the upper airway. Only one of the patients with cellulitis had the classic bluish-purple hue commonly seen in children affected with this syndrome. In the other two, the H. influenzae type B cellulitis could not be distinguished clinically from the more common group A streptococcal or staphylococcal cellulitis. Since the antibiotics employed in treating patients with infection due to the latter two organisms differ significantly from those used to treat patients with H. influenzae type B infection, the possibility of disease due to H. influenzae type B must be considered in any adult or child in whom cellulitis of the neck, chest and possibly face is associated with a respiratory tract infection, especially of the upper airway.
Am J Med 1977 Sep
PMID:Bacteremic hemophilus influenzae type B cellulitis in the adult. 30 44

A survey of 158 children with acute haematogenous osteomyelitis, and of 94 children with acute septic arthritis over an 8-year period was made to determine which bacteria cause these infections. In the osteomyelitis group the organism most frequently detected was Staphylococcus aureus (74% of cases). In 16% of cases streptococci were found. Staph. aureus was also the most frequently grown organism in cases of acute septic arthritis (55% of cases), but Haemophilus influenzae accounted for 24% of positive cultures. On the basis of the survey it is the current practice of the author to use a combination of methicillin or cloxacillin and penicillin for acute haematogenous osteomyelitis, and methicilline or cloxacillin and ampicillin for acute septic arthritis. The choice of antibiotics is vitally important as treatment must start before the results of culture are known. Repeated evaluation of trends in the pattern of causative organisms is strongly recommended, in order to be aware of changing sensitivity of organisms to antibiotics.
Arch Dis Child 1977 Sep
PMID:Choice of antibiotics in management of acute osteomyelitis and acute septic arthritis in children. 30

Cellitis that is caused by Haemophilus influenzae demonstrates a unique predilection for the faces of young children. Although previously considered a rare entity, it is currently being recognized more frequently. Despite the importance of early recognition and treatment in preventing potentially fatal complications, it has been noticeably neglected in the otolaryngologic literature. We report a case and discuss the diagnosis and management of H influenzae cellulitis.
Arch Otolaryngol 1978 Sep
PMID:Haemophilus influenzae cellulitis. 30 65

When competent Haemophilus influenzae were returned to complete growth medium, they resumed growth at once and underwent a synchronous division after 20 to 25 min. The rate of DNA synthesis increased to the definitive rate very quickly after resumption of growth. In contrast, the rate of RNA synthesis remained low until the time of division, at which time it accelerated dramatically. Changes in the rate of protein synthesis were similar in form to those of RNA synthesis. The kinetics of loss of competence upon resumption of growth had a pattern similar to the rate of RNA synthesis, and both processes accelerated markedly at the time of cell division, suggesting an inverse relationship between RNA synthesis and the ability to take up DNA.
J Bacteriol 1978 Sep
PMID:Synchronous division and rates of macromolecular synthesis in Haemophilus influenzae competent for genetic transformation. 30 8

The carriage rate of ampicillin-resistant Hemophilus influenzae type B in a chronic care facility was investigated. Up to 48% of the children carried this strain. Of interest was the finding of simulaneous carriage of ampicillin-resistant and ampicillin-sensitive HITB, a phenomenon which was detected by using both chocolate agar and chocolate agar containing 2 microgram/ml of ampicillin. A trial of sulfamethoxazole-trimethoprin successfully eradicated the ampicillin-sensitive HITB, but had no effect on the ampicillin-resistant HITB.
J Pediatr 1978 Sep
PMID:Effect of TMP-SMX on nasopharyngeal carriage of ampicillin-sensitive and ampicillin-resistant hemophilus influenzae type B. 30 33

In vitro activity of cefuroxime, a new cephalosporin stable to bacterial beta-lactamases, was compared with that of cefalothin and other cephalosporins by serial dilution test in more than 600 bacterial strains. Cefuroxime was more active than cefalothin on most strains of Gram negative bacilli (except Salmonella species) and also on most strains of cefalothin-resistant bacteria. In comparison to cefalothin, cefoxitin and cefamandol, cefuroxime exerted the strongest activity on meningococci, streptococci of group A and B and also on Citrobacter freundii. It was as active as cefamandol and more active than cefalothin and cefoxitin on Haemophilus influenzae (also in ampicillin-resistant strains). Pharmacokinetic studies were performed in 10 healthy adult volunteers after i.v. injection of 0.75 g, 1 g, and 1.5 g cefuroxime and of 1 g cefalothin. Cefuroxime was superior to cefalothin by slower renal excretion, longer half-life, lesser or no metabolization and better tissue penetration. Cefuroxime is well tolerated and should be administered in adequate doses corresponding to the severity of the disease and the susceptibility of the causative agent.
Schweiz Med Wochenschr 1978 Sep 09
PMID:[Cefuroxim, a new beta-lactamase stable cephalosporin]. 30 78

CP-45,899 {3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 4,4-dioxide, [2S-(2alpha,5alpha)]} is an irreversible inhibitor of several bacterial penicillinases and cephalosporinases. In the presence of low concentrations of CP-45,899, ampicillin and other beta-lactams readily inhibit the growth of a variety of resistant bacteria that contain beta-lactamases. CP-45,899 used alone displays only weak antibacterial activity, with the notable exception of its potent effects on susceptible and resistant strains of Neisseria gonorrhoeae. CP-45,899 appears to be somewhat less potent but markedly more stable (in aqueous solution) than the recently described beta-lactamase inhibitor clavulanic acid. The spectrum extensions provided by the two compounds are similar. A 1:1 mixture of CP-45,899 and ampicillin displays marked antimicrobial activity in mice experimentally infected with ampicillin-resistant Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumoniae, and Proteus vulgaris.
Antimicrob Agents Chemother 1978 Sep
PMID:CP-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterization. 30 6

17 infants and children with pyogenic meningitis (14 Haemophilus influenzae, 2 Diplococcus pneumoniae, 1 Neisseria meningitidis) were treated with thiamphenicol, 100 mg/kg body weight/day in 4 doses i.v., as single drug. In the H. influenzae group 10 patients were cured, 4 had relapses of meningitis, 3 with documented subdural effusions. This group is compared with 14 children matched for age, initial leucocyte and CSF cell count treated with ampicillin: all of these were cured, 1 had a subdural effusion. Thiamphenicol concentrations were determined in the serum and CSF 2 h after administration. The mean serum levels were between 10-12 mcg/ml, the mean CSF levels varied from 5.4 mcg/ml at the beginning to 1-1.9 mcg/ml at the end of meningitis. The MIC of H. influenzae was 0.6-12 mcg/ml. A significant, acute, and dose related bone marrow toxicity of thiamphenicol could be documented, but was always rapidly fully reversible. We conclude that thiamphenicol cannot replace chloramphenicol in the treatment of pyogenic meningitis as single systemic antibiotic. Special indications for thiamphenicol in this disease are discussed.
Helv Paediatr Acta 1977 Sep
PMID:Thiamphenicol in treatment of Haemophilus influenzae meningitis. 31 71


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