Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Doxycycline levels were measured in 44 patients undergoing lung surgery; 44 determinations were made on serum, 37 on resected lung tissue, 11 on bronchial wall, and 8 on bronchial secretions. The concentrations in lung tissue were, with few exceptions, higher than the serum concentrations, while those in homogenized bronchial wall specimens were slightly lower than the serum readings. All these concentrations were on average considerably higher than the minimum inhibitory concentrations for the pneumococcus and Haemophilus influenzae. The comparatively low bronchial secretion concentrations were accounted for by the surgical circumstances. All patients had been intensively trated pre-operatively, and showed no florid mucosal inflammation at the time of the operation: as inflammation subsides, so the antibiotic concentration in the bronchial secretion declines rapidly. The lung and bronchial wall tissue levels indicate that doxycycline has great promise in the treatment of pulmonary and bronchial disorders.
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PMID:Doxycycline concentrations in lung tissue, bronchial wall, and bronchial secretions. 115 79

Seventeen years after a previous study of doxycycline in acute purulent exacerbations of chronic bronchitis, a similar investigation was repeated. Forty patients with bacteriologically proven infections were given 100 mg doxycycline twice daily (by mouth) for ten days. The clinical results in Branhamella catarrhalis infections were excellent as were those with Streptococcus pneumoniae, but one patient developed septicaemia with a resistant pneumococcus while under therapy. Treatment was unsuccessful in a third of the patients with Haemophilus influenzae infections. Overall, excellent or good results were recorded in 74% of patients at the end of treatment, and in 64% a week later. Doxycycline is still a useful oral antibiotic in this condition and possibly the best for B. catarrhalis infections, especially with beta-lactamase producing strains.
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PMID:Doxycycline in respiratory infections: a re-assessment after 17 years. 377 34