Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The activities of azlocillin and mezlocillin were compared with those of carbenicillin, ticarcillin, and pirbenicillin against a wide range of gram-negative organisms. The two new drugs were considerably more active than carbenicillin against Klebsiella species and Escherichia coli. Carbenicillin was twice as active against Proteus mirabilis as mezlocillin and four times as active as azlocillin. Against Pseudomonas aeruginosa, azlocillin was eight times as active as carbenicillin. Azlocillin and mezlocillin were twice as active as carbenicillin against Bacteroides fragilis, and these drugs showed a high degree of activity against Haemophilus influenzae and Neisseria gonorrhoeae.
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PMID:Activity of azlocillin and mezlocillin against gram-negative organisms: comparison with other penicillins. 9 26

The mechanism of action, resistance, antibacterial spectrum, clinical pharmacology, adverse effects, and therapeutic and prophylactic use of penicillins are reviewed. The choice of a penicillin is discussed. The only indication for the penicillinase-resistant penicillins is the suspected or demonstrated presence of Staphylococcus aureus. There are no important differences in therapeutic effect among oxacillin, cloxacillin, dicloxacillin or flucloxacillin by the oral route, or among oxacillin, dicloxacillin, nafcillin or methicillin parenterally. Ampicillin is especially useful for infections due to Haemophilus influenzae and Escherchia coli and for serious disease due to enterococcus and Listeria monocytogenes. Carbenicillin and ticarcillin exhibit unique activity against gram-negative bacilli (except Klebsiella).
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PMID:Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics. Part 2: penicillins. 31

Despite the availability of numerous beta-lactam antibiotics, benzylpenicillin remains the most important beta-lactam antibiotic in the treatment of bacterial endocarditis. Penicillin alone and in combination with an aminoglycoside is effective in the treatment of endocarditis due to all streptococci, Streptococcus pneumoniae, penicillin-susceptible Staphylococcus aureus, Haemophilus aprophilus, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Listeria monocytogenes. Oral phenoxymethylpenicillin in combination with streptomycin is effective in treating endocarditis due to viridans streptococci. Ampicillin is effective in endocarditis due to Haemophilus influenzae, H. parainfluenzae, H. paraphrophilus, Listeria monocytogenes and Escherichia coli. Oral amoxicillin with gentamicin has been used to treat enterococcal endocarditis. The penicillinase-resistant penicillins are effective in treating S. aureus endocarditis. Carbenicillin or ticarcillin in combination with tobramycin or gentamicin are used to treat endocarditis due to Serratia marcescens and Pseudomonas aeruginosa. The use of piperacillin in combination with tobramycin against P. aeruginosa endocarditis has been associated with failure and increased resistance. The cephalosporins have been used to treat endocarditis caused by susceptible organisms. There have been few data on the efficacy of the newer cephalosporins in treating endocarditis. They have been used to treat septicaemia due to susceptible organisms with good results.
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PMID:The use of beta-lactam antibiotics in the treatment of septicaemia and endocarditis. 644 9

A 79-year-old female developed endocarditis and meningitis due to an ampicillin-resistant, non-beta-lactamase-producing strain of Haemophilus influenzae. Carbenicillin and gentamicin therapy resulted in bacteriological and clinical cure. The mechanism of resistance of ampicillin-resistant, non-beta-lactamase-producing strains of H. influenzae is unknown.
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PMID:Isolation of an ampicillin-resistant, non-beta-lactamase-producing strain of Haemophilus influenzae. 696 43

Freshly isolated strains of Haemophilus influenzae type B were studied for their in vitro susceptibility to eight antibiotics with a low concentration inoculum. No organisms were identified as being resistant to ampicillin, but minimal inhibiting concentrations for that antibiotic were somewhat higher than reported previously for a similar method. Carbenicillin and ticarcillin resembled ampicillin in activity, and the three agents were more effective on a weight basis than the other agents tested.
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PMID:In vitro susceptibility of Haemophilus influenzae to eight antibiotics. 1582 79