Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This article reports a case of pyogenic arthritis with Hemophilus influenzae in a previously healthy woman. This infection was the initial manifestation of an underlying serious systemic illness, multiple myeloma. Certain laboratory parameters as well as the causative organism suggested the underlying disease. Although infections are common in patients with known multiple myeloma, certain infections can provide a hint to concomitant serious systemic diseases and thus facilitate their early diagnosis.
 ...
PMID:Multiple myeloma presenting with Hemophilus influenzae septic arthritis: case report and review of the literature. 837 Dec 86

A review of Haemophilus influenzae (Hi) infections in Mexico over the past 32 years was conducted. The proportion of Hi isolates in relation to positive cultures for distinct diseases was distributed as follows for meningitis (9-69%) and for pneumonia with empyema (6-28%). There was no difference in the proportion of Hi isolation between under developed countries and the United States. In other diseases such as septic arthritis, epiglottitis, acute otitis media, acute maxillary sinusitis and in the nasopharyngeal carrier state, the information was too limited. The incidence of Hib invasive disease has been almost eliminated in some areas of the world related to the use of Hib conjugated vaccine. It is imperative for the practitioner to be aware of the advantages of Hib vaccine in infancy.
 ...
PMID:[The impact of Haemophilus influenzae infections on Mexican children]. 851 38

A healthy 3.5-month-old infant developed septic arthritis with Haemophilus influenzae type f isolated from the knee aspirate and blood. The patient had no obvious risk factors and immunological evaluation revealed no abnormalities. To our knowledge, there are only two reported childhood cases of septic arthritis caused by non-type b H. influenzae, but this is the first one to be reported in a child without an underlying disorder. The importance of serotyping H. influenzae isolates in the H. influenzae type b vaccine era, and the need to look for predisposing factors in paediatric patients with invasive disease caused by non-type b H. influenzae are discussed.
 ...
PMID:Septic arthritis caused by an unusual type of Haemophilus influenzae. 870 72

We studied the clinical spectrum, serotypes and antimicrobial resistance of Haemophilus influenzae received by our laboratory. The majority of cases involved the elderly (more than 60 years old) and children under the age of 5 years. Most infections involved the respiratory tract and were caused by non-serotypable strains. Invasive infections (meningitis, septic arthritis and bacteraemia) were infrequent and were caused by both type b and non-serotypable strains. The estimated incidence of invasive Haemophilus influenzae type b disease in children under the age of 5 years is at most 5 per 100 000 a year. Resistance to ampicillin (40.5%) and trimethoprim-sulfa (37.7%) was high and would affect the choice of antimicrobials used for treating Haemophilus influenzae infections.
 ...
PMID:Serotypes and antimicrobial resistance in Haemophilus influenzae in a hospital practice. 879 2

Data from 1158 cases of septic arthritis reported to the Public Health Laboratory Service (PHLS) Communicable Disease Control Centre (CDSC) from England and Wales over a 4 yr period (January 1990 December 1993) are presented. Reports where a bacterial organism was isolated from synovial fluid, or where an organism was isolated from blood cultures where a diagnosis of septic arthritis was reported, were examined. Reports of infection were more common in children (12.7% of infections were in the under 10 age group) and the elderly (54.7% aged 60 or over), and were higher in males in all age groups except in the elderly. The most common causative organisms remain staphylococcal and streptococcal species, comprising 40.6% (470) and 28% (324) of cases, respectively. The most common streptococci seen were Streptococcus pneumoniae and Lancefield group A beta-haemolytic Streptococcus organisms, 60.8% (197/324), although group B, C and G organisms accounted for 33.6% of streptococcal isolates (109/324). Haemophilus influenzae septic arthritis is not exclusive to children as 23.2% (16-69) of cases occurred over the age of 15. A total of 48% (635) of isolates were identified from both synovial fluid and blood cultures, 32.6% (378) from joint fluid alone and 12.5% (146) from blood cultures. Although this study excludes cases of septic arthritis where no organism was isolated, it presents important bacteriological information from a large number of isolates from England and Wales over a 4 yr period. Risk factors identified include a joint prosthesis, joint disease/connective tissue disorder. immunosuppression and diabetes.
 ...
PMID:Bacterial joint infections in England and Wales: analysis of bacterial isolates over a four year period. 913 71

Haemophilus influenzae has been a major cause of infectious diseases in children and has been attributed as a significant cause of septic arthritis and osteomyelitis in children. With the advent of widespread vaccination, the incidence of Haemophilus influenzae meningitis and other infections has been well documented. This is thought to be the first report that documents the effect of vaccination on bone and joint infections. One hundred sixty-five cases of acute hematogenous osteomyelitis or septic arthritis treated at the Department of Orthopaedics at Vanderbilt University in the years before and after the advent of the Haemophilus influenzae vaccine to assess whether vaccination affected the incidence of these diseases. The data indicate that the Haemophilus influenzae vaccine has reduced to near 0 the incidence of bone and joint infections because of Haemophilus influenzae. These findings suggest that coverage of Haemophilus influenzae as part of the empiric antibiotic coverage may be no longer needed in the management of acute hematogenous osteomyelitis and septic arthritis in children.
 ...
PMID:Decline of bone and joint infections attributable to haemophilus influenzae type b. 926 65

Sixty children younger than 3 years with culture-positive hematogenous septic arthritis and acute/subacute osteomyelitis treated between 1990 and 1995 were reviewed to identify the infecting organism. Gram-positive bacteria were identified in 47 (78.3%) patients, and gram-negative organisms were identified in 13 (21.7%) patients. Haemophilus influenzae was cultured in none of the cases of septic arthritis and in only one (1.6%) case of acute osteomyelitis. Kingella kingae was cultured in 10 (16.7%) cases, with all of these patients between the ages of 10.5 and 23.5 months. Routine immunization of infants against H. influenzae has caused a change in the historically reported bacteria of bone and joint infections in children younger than 3 years. Haemophilus influenzae has lost its predominance as the most commonly identified gram-negative pathogen, and in this study, has been replaced by K. kingae.
 ...
PMID:Increasing prevalence of Kingella kingae in osteoarticular infections in young children. 953 14

This report describes dual infection with Citrobacter freundii and Haemophilus influenzae type b causing septic arthritis and osteomyelitis of the elbow in a previously healthy 5-year-old boy. The patient was treated successfully with intravenous fosfomycin for 4 weeks. Infections with Citrobacter beyond the neonatal period are rare in paediatric patients. When Citrobacter spp. is isolated, coinfection with other bacterial pathogens should be considered.
 ...
PMID:Osteomyelitis and septic arthritis due to Citrobacter freundii and Haemophilus influenzae type b. 956 50

In many countries Haemophilus influenzae type b (Hib) is the second most common cause of septic arthritis in children. In Finland large-scale immunisation against Hib using conjugate vaccines began in 1986, four years after a multicentre prospective study of orthopaedic infections in children had started. Since 1982, including six years before and ten after starting routine Hib vaccination, there has been a major change in the pattern of septic arthritis. From 1982 to 1988, 32 of 61 cases (53%) were caused by staphylococci, 22 (36%) by Hib and 7 (11%) by other bacteria. Since 1988, Hib infection has disappeared, and one-third of cases of childhood septic arthritis has been eliminated. This change has allowed us to reduce initial antimicrobial therapy for such children to cover only Gram-positive cocci. The more limited treatment is safer, reduces cost, and simplifies treatment.
 ...
PMID:Reduced incidence of septic arthritis in children by Haemophilus influenzae type-b vaccination. Implications for treatment. 961 39

Reports pertinent to bacterial arthritis in 1997 included two large, multi-year surveys of joint infection in patients from defined European health districts, noting trends including the declining incidence of gonococcal arthritis and an increasing number of prosthetic joint infections. Children with infected joints generally fare better than adults despite having proportionately more infections due to gram-negative organisms, of which Hemophilus influenzae comprises an ever smaller portion as the fastidious Kingella kingea is emerging. Joint infections remain an uncommon complication of immunodeficiency due to HIV, with responsible agents, affected sites, and clinical course also influenced by certain HIV comorbidities such as intravenous drug user and hemophilia. The rare immunodeficient patient with hypogammaglobulinemia retains a nearly unique susceptibility to joint infection with mycoplasmas, which can cause considerable morbidity if not promptly recognized and treated. Polymerase chain reaction can detect remnants of bacteria in the face of negative conventional cultures, but inoculation of synovial fluid into blood cultures bottles may be a more immediate and practical method to increase the yield in suspected septic arthritis.
 ...
PMID:Bacterial arthritis. 972 94


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>