Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hemophilus influenzae is an uncommon, seldom considered pathogen of septic arthritis in adults. H. influenzae seems not to have been reported in association with a total joint infection. The majority of previously reported H. influenzae cases have been associated with joint trauma or preexisting joint disease. A 63-year-old woman with a late hematogenous infection due to H. influenzae of a total hip arthroplasty was treated by surgical debridement and appropriate antibiotics. In a short-term follow-up evaluation of one year, this treatment was successful in allowing retention of the prosthesis and return to satisfactory function.
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PMID:Hemophilus influenzae infection of a total hip arthroplasty. 404 77

In the period November 1967 to September 1968 Haemophilus influenzae type b was isolated from the blood of 11 young children. Only three of these presented with meningitis; others had septic arthritis, oesteomyelitis, subcutaneous abscesses, cellulitis, respiratory infections, and undifferentiated pyrexia. During the preceding five years H. influenzae type b was isolated from the blood cultures of 15 patients, and all but two of these were cases of meningitis. Blood culture has proved of value in establishing the role of H. influenzae type b in a broad spectrum of acute infections, and the suggestion is made that meningitis may represent only a minority of cases of haemophilus septicaemia. Because H. influenzae is resistant to some antibiotics bacteriological diagnosis of such cases is important if the correct treatment is to be given.
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PMID:Haemophilus influenzae type B septicaemia. 530 88

Hemophilus influenzae is an important but uncommon cause of adult septic arthritis. We report two cases and review 23 previously published cases. Two-thirds of the patients had systemic diseases, local factors, or both which predisposed them to septic arthritis. The acute disease was monarticular in 48%, polyarticular in 24%, and accompanied by tenosynovitis and/or bursitis in 28% of cases. Extraarticular sites of H. influenzae infection were found in 60% of cases. These sites represented either likely portals of bacterial entry or foci of infection resulting from hematogenous dissemination of H. influenzae. The most characteristic synovial fluid finding was the presence of Gram-negative pleomorphic microorganism. However, misinterpretation of the Gram-stained smear was common and led to an erroneous initial diagnosis in several instances. Prompt sterilization of the infected synovial fluid was the rule once an appropriate antimicrobial agent was administered. A favorable outcome was reported in 88% of cases.
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PMID:Hemophilus influenzae septic arthritis in adults. 634 91

The main use of the penicillins in orthopedic surgery is in the treatment of infections due to Hemophilus influenzae, Staphylococcus aureus, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Escherichia coli, Proteus mirabilis, Streptococcus pneumoniae, and Group D streptococci (enterococci). Penicillins have antimicrobial activity and have a characteristic pharmacodynamic action, including side effects. The tissue penetration characteristics of the penicillins into synovial fluid and human bone are significant. Semisynthetic penicillins, antistaphylococcal penicillins, and the antipseudomonal penicillins are used for treatment of septic arthritis and osteomyelitis. Oral penicillin therapy can be useful in treatment of osteomyelitis.
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PMID:The use of penicillins in orthopaedic surgery. 648 49

Three cases of ampicillin-resistant Hemophilus influenzae type B septic arthritis are described. These patients presented over a four-month period (November 1978 to February 1979). All were less than 18 months of age, all had positive blood and joint aspirate cultures, and counter-current immunoelectrophoresis (CIE) on serum positive for Hemophilus influenzae type B. The ampicillin minimum inhibitory concentration (MIC) for all three isolates was 6.25 microgram/ml or greater. All patients recovered uneventfully with intravenous chloramphenicol therapy. We suggest that chloramphenicol be considered in the initial therapy of children under 18 months of age who present with septic arthritis, at least in geographic areas where the incidence of ampicillin resistance is high.
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PMID:Ampicillin-resistant Hemophilus influenzae type B septic arthritis in children. 697 Jan 9

The incidence of Haemophilus influenzae infections appears to be increasing although disease in adults due to this organism remains unusual. Only 16 cases of septic arthritis caused by this agent were found in a review of the literature. Two additional cases are reported and a summary of the clinical characteristics of these patients is presented. In general, females are affected more commonly than males, and blacks more often than whites. Joint involvement may be single or multiple, and associated or underlying conditions are frequent. Treatment with a variety of antimicrobials was generally successful and 87% of the infected joints was restored to pre-infection status. There were no specific characteristics in the clinical presentation which would allow an early precise etiologic diagnosis.
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PMID:Haemophilus influenzae septic arthritis in adults. 698 42

Thirty-two infants and children ranging in age from 3 to 151 months (mean, 26 months) were treated with parenteral cefoxitin (150 mg/kg per day). Ten patients with isolates of Haemophilus influenzae (six with cellulitis, two with arthritis, and two with mastoiditis), four with Staphylococcus aureus (one with lymphadenitis, one with septicemia, and two with abscess), and three patients with Streptococcus pneumoniae (one each with cellulitis, abscess, and arthritis), were clinically and bacteriologically cured by therapy. Two additional patients with septic arthritis and facial cellulitis developed meningitis with H. influenzae type b and S. pneumoniae, respectively. Minimal inhibitory and bactericidal concentrations were </=5 mug/ml for 15 isolates. Minimal bactericidal concentrations were >20 mug/ml for one strain of S. aureus and one of H. influenzae type b. The mean peak serum levels were 81.9 and 68.5 mug/ml 15 min after intravenous or intramuscular doses, respectively. The mean elimination half-lives were 42.4 and 40.1 min after intravenous or intramuscular doses, respectively. The mean volumes of distribution were 5,540 and 4,760 ml after intravenous and intramuscular doses, respectively. Mean plasma clearance was 242 and 257 ml/min per m(2) after intravenous and intramuscular doses, respectively. Therapy was discontinued in one patient because of neutropenia, which resolved after cefoxitin was stopped. Eosinophilia and transiently elevated liver function tests occurred in eight and six patients, respectively. These data indicate that cefoxitin may be an effective treatment for infections due to susceptible bacteria in the dosage tested, but its use may be limited because of the occurrence of meningitis during therapy in some patients.
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PMID:Clinical and pharmacokinetic evaluation of parental cefoxitin in infants and children. 739 56

Septic arthritis is a synovial infection of bacterial origin. Such a diagnosis, suggested by pain and diminished resistance to infection, should be confirmed by puncture of the joint effusion. The condition calls for emergency hospitalisation and treatment in a surgical unit. Treatment should include draining and cleaning of the joint, immobilization at least in the early stages, and double parenteral antibiotic administration. Clinical, radiological and laboratory follow-up (CRP and ESR) should be pursued. Detection of the responsible germ is often difficult and requires great care in sampling and analysis. The frequency of Haemophilus in children under 4 years of age requires adaptation of antibiotic therapy. In newborns, diagnosis is often difficult and delayed, explaining the frequency of sequelae in this age group. The only important prognostic factor is the interval before beginning treatment.
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PMID:[Septic arthritis in children]. 785 26

A case of septic arthritis due to Haemophilus aphrophilus is presented. This organism has rarely been reported as a cause of bone or joint infections. We believe this is the third reported case of septic arthritis caused by this microorganism. We review the clinical and bacteriologic findings and the previously reported cases of infection caused by H. aphrophilus. Treatment with ceftriaxone was followed by full recovery without sequelae.
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PMID:Haemophilus aphrophilus as a rare cause of arthritis. 798 6

Cefepime, a novel, injectable alpha-methoxyimino aminothiazolyl cephalosporin, is active in vitro against many of the Gram-positive and Gram-negative bacteria which cause severe infections, including Pseudomonas aeruginosa. It is more active than existing third-generation cephalosporins against multiply-resistant strains of Enterobacteriaceae because of its low affinity for beta-lactamases and its resistance to hydrolysis by these enzymes. Cefepime retains its high potency of activity against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci and streptococci other than enterococci. Seventy-four patients (46 male and 28 female) were treated with cefepime 2 g i.v. every 12 h; 61 patients were evaluable for efficacy (39 male and 22 female). The infections included pneumonia caused by Gram-negative bacilli (21 patients, six with bacteraemia), septicaemia (seven), pyelonephritis (two), osteomyelitis (23, mainly caused by S. aureus), septic arthritis (four) and soft tissue infections (four, one with bacteraemia). Responses were as follows: 52 (85.3%) patients cured; three (4.9%) improved and six (9.8%) failed. The failures included three patients with osteomyelitis, one with pyelonephritis and two with pneumonia. The pathogens and eradication rates were: S. aureus 23/24 (96%), Staphylococcus epidermidis 4/4, Streptococcus spp. 10/10 (100%), P. aeruginosa 11/14 (79%), Enterobacteriaceae 28/28 (100%), Haemophilus spp. 3/3 and others 7/7. Clinical adverse effects included diarrhoea in 11 patients (14.9%) nausea in five (6.8%) and pruritus in three (4.1%). Laboratory abnormalities included leucopenia in three patients (4.1%) and direct Coombs' conversion in 32 (43.2%). Patients were treated for an average of 31.8 days for osteomyelitis and 11.9 days for other infections.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Cefepime as treatment for osteomyelitis and other severe bacterial infections. 815 Jul 58


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