Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three hundred and thirteen transtympanic aerators (TTA), including 309 T-tubes, were inserted between november 1985 and April 1987 at the Bretonneau hospital, Paris. Twenty-three (7%) were expelled spontaneously, 16 (5%) became obstructive and in 6 cases a change of TTA was required. The commonest complication was otorrhea. Younger children tended to develop early otorrhea. There were 7 cases (2%) of early otorrhea and 50 (16%) of secondary otorrhea. By contrast the onset of secondary otorrhea was independent of age. A relationship with penetration of water into the middle ear through the TTA could not be confirmed. At the present time the authors permit bathing without any special precautions. In parallel, between november 1985 and august 1987, 84 bacteriological samples were obtained in cases of otorrhea related with a TTA, whether or not the latter had been inserted at Bretonneau. Predominant organisms were Hemophilus influenzae (30%), Pseudomonas aeruginosa (30%) and Staphylococcus (18%). On the basis of results of antibiotic sensitivity studies using the organisms discovered in these samples, the authors suggest local therapy based upon polymyxin or rifamycin as treatment of first choice.
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PMID:[Short-term complications of transtympanic aerators]. 284 50

The authors report the results of the study of 435 bacteriological samples taken in children presenting with acute otitis media, in the out-patient department of ENT at the hospital Bretonneau (Paris) and in Valognes (Manche) from October 1981 to September 1987. Three bacterial organisms prevailed: Haemophilus (37 and 22% respectively), S. pneumoniae (25 and 7%) and Staphylococcus (16 and 17%). Pseudomonas was fairly frequent in cases with otorrhea, even when recent. Comparison with other studies shows the clear progression of the incidence of Haemophilus in acute otitis media. The percentage of the strains secreting a beta-lactamase was 17% whether the children live in the country or in town. The frequency of S. pneumoniae was independent of age but was clearly lower in cases with prolonged or relapsing otitis. According to these results, the authors discuss the therapeutic strategy for acute otitis media. Amoxicillin still remains the antibiotic of choice. In case of persisting or relapsing otitis, the bacteriological examination will allow choosing the best adapted antibiotic: first generation cephalosporin, clavulanic acid and amoxicillin or trimethoprime and sulfamethoxazole.
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PMID:[Bacteriologic study of acute otitis media in hospitals and private practice]. 320 71