Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ninety-four patients with acquired tracheobronchomalacia were followed up between 1967-1977, for an average of 5.2 years. Fifty-six were still alive at the end of the period, and 47 of these were reexamined. Twenty-one patients had retired on pensions for lung disease. Of the 36 patients who underwent rebronchoscopy, tracheomalacia alone was seen in 3 and tracheobrochomalacia in 33. Six out of the 9 cases of tracheomalacia and all the 5 cases of bronchomalacia had developed into tracheobronchomalacia. The malacia was mild in 6 (17%), moderate in 8 (22%) and severe in 22 (61%), against the figures of the preceding bronchoscopy: 13 (36%), 17 (47%) and 6 (17%), respectively. Mild bronchitic changes were seen in 9 (25%) and severe in 22 (61%) bacterial cultures grew Haemophilus, Proteus mirabilis and Klebsiella, and the culture was positive on 8 occasions (22%). A fungal culture of the bronchial aspirate was positive in 9 cases (25%). No pronounced eosinophilia on the bronchial mucosa was observed.
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PMID:Acquired tracheobronchomalacia. A bronchological follow-up study. 61 25

This study aimed to determine the aetiology, clinical presentation, co-morbidity, severity and the lobar distribution of non cystic fibrosis bronchiectasis (NCFB). We performed a retrospective review of clinical, radiological, immunological and microbiological data from 92 non-CF patients with a High resolution thoracic CT (HRCT) diagnosis of bronchiectasis in the three Dublin Children's referral Hospitals for the period 1996-2006. Of 92 patients (50 female), the median age at diagnosis was 6.4 years. The aetiology of bronchiectasis was as follows; idiopathic 29 (32%), post-pneumonia 16 (17%), immune deficiency 15 (16%), recurrent aspiration 15 (16%), primary ciliary dyskinesia 8 (9%), chronic aspiration with immune deficiency 5 (5%), post foreign body inhalation 2 (2%), tracheomalacia 1 (1%) and Obliterative bronchiolitis 1 (1%). Bronchial asthma and gastroesophageal reflux disease (GORD) were concurrently present in 18 (20%) and 10 (11%) respectively. Left lower lobe was commonly involved followed next by the right middle lobe. The common isolates were Haemophilus influenza (50), Streptococcus pneumoniae (34) and Staphylococcus aureus (14), Moraxella catarrhalis (9) and Pseudomonas auerginosa (8). Surgical interventions were performed in 23 (25%) of patients, lobectomy 11 (12%), pneumectomy 2 (2%), laryngeal cleft repair 4 (5%), rigid bronchoscopy for foreign body removal 2 (2%), Nissan's fundoplication 2 (2%), tracheoesophageal fistula repair 2 (2%). We conclude NCFB is under-recognised in Irish children and diagnosis is often delayed and Bronchial Asthma and GORD are common co morbidity. A high index of suspicion and early HRCT can expedite the diagnosis.
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PMID:A decade of non-cystic fibrosis bronchiectasis 1996-2006. 2066 70