Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A prospective cohort study of 129 consecutive patients developing pulmonary infiltrates in the surgical ICU was conducted to determine the predictors and outcome of pulmonary infiltrates. Most common etiologies of pulmonary infiltrates were pneumonia (30%), pulmonary edema (29%), acute lung injury (15%), and atelectasis (13%). Enteral nutrition was associated with a significantly lower incidence of acute lung injury as compared with pneumonia (22% vs 58%, p = 0.012). Patients with liver disease were significantly more likely to have pulmonary infiltrates due to acute lung injury as compared with other etiologies (p = 0.02). Clinical pulmonary infection score (Pugin score) > 6 virtually excluded acute lung injury, pulmonary edema, or atelectasis as etiologies of pulmonary infiltrates. Nosocomial Haemophilus/pneumococcal pneumonia occurred significantly earlier in the ICU as compared with Gram-negative (p = 0.05) or methicillin-resistant Staphylococcus aureus pneumonia (p = 0.01). Pneumonia in trauma patients was significantly more likely to be due to Haemophilus/pneumococcus as compared with all other ICU patients (54% vs 0%, p = 0.0004). These data have implications for treatment of patients with nosocomial pneumonia in the ICU.
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PMID:Pulmonary infiltrates in the surgical ICU: prospective assessment of predictors of etiology and mortality. 979 88

Viral influenza is a seasonal cause of community-acquired pneumonia (CAP). Viral influenza may be caused by influenza A or B and affect any age group. Viral influenza A is usually more severe than influenza B in adults. Viral influenza may present as 3 clinical scenarios: viral influenza alone, viral influenza followed in 1 to 3 days by Staphylococcus aureus pneumonia, or viral influenza followed in 1 to 3 weeks by pneumonia caused by Streptococcus pneumoniae or Haemophilus influenzae. Intravenous drug abusers (IVDAs) are predisposed to a variety of infectious diseases but are not particularly predisposed to viral influenza. We present a case of a young IVDA who presented with influenza A pneumonia who subsequently developed S. pneumoniae CAP. The pneumonococcal suprainfection was severe and prolonged and characterized by a small cavity, empyema, pneumatoceles, and bronchopleural fistulae. S. pneumoniae pleural effusions are uncommon, but pleural empyemas are often demonstrated. Tracheobronchial fistulae and cavitation are rare complications of S. pneumoniae CAP in adults. To the best of our knowledge, this is the first case of post-viral influenza pneumococcal pneumonia in an IVDA.
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PMID:Post-viral influenza Streptococcus pneumoniae pneumonia in an intravenous drug abuser. 1601 28