Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gardnerella-associated vaginosis (Hemophilus vaginalis vaginitis, nonspecific vaginitis) is the most common cause of vaginal discharge and odor. The clinical spectrum of this infection varies from total lack of symptoms to obvious odor and profuse vaginal discharge. The diagnosis of this syndrome can be made when a woman presents with a homogenous grey-white discharge that emits a fishy odor when a drop of 10% potassium hydroxide is mixed with a drop of vaginal discharge on a glass slide. The pH of this secretion is typically in the range of 5.0-5.5 as determined by indicator paper. The diagnosis is further confirmed when a microscopic examination of the discharge mixed with normal saline shows a virtual pure culture of tiny bacteria many of which are found clinging to vaginal epithelial cells forming the so-called "clue cells". Cultures to isolate Gardnerella vaginalis are unnecessary in clinical practice.
 ...
PMID:The clinical signs and symptoms of Gardnerella-associated vaginosis. 660 25

Nonspecific vaginosis (NSV) is a very common clinical syndrome with characteristic clinical, biochemical, and microbiologic features. There is a thin, malodorous homogeneous, grey, nonpurulent vaginal discharge. The discharge usually has a pH greater than 4.5, contains "clue cells" on wet mount examination, and produces a "fishy" odor when mixed with 10% potassium hydroxide. The discharge contains an increased concentration of at least seven amines which are presumably produced by bacterial decarboxylases; and several volatile and non-volatile organic acid metabolites of anaerobic bacteria. Although the pathogenesis of NSV is not understood, the normal, lactobacillus-dominated microbial flora is replaced by Gardnerella (Haemophilus) vaginalis and certain anaerobic species. Treatment with sulfonamide creams or oral tetracycline is usually ineffective. Ampicillin is often effective, but metronidazole appears to be the most effective antimicrobial for this condition. The optimal dose of metronidazole, and the need for treatment of sex partners, require further study.
 ...
PMID:Nonspecific vaginosis. 694 46