Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rarely is endocarditis attributed to the species of Hemophilus. Most frequently implicated are H aphrophilus and H parainfluenzae, but H influenzae also is seen. We report six cases of endocarditis due to H aphrophilus or H parainfluenzae and review the literature. Emboli to skin, lungs, kidneys, spleen, brain, and other organs are common complications, and acute glomerulonephritis and meningitis often occur. Ampicillin is the mainstay of antimicrobial therapy for patients whose isolates are sensitive to it, but the duration of antimicrobial therapy necessary for eradication of the infection is not clear. Studies of antimicrobial synergism are warranted in instances of endocarditis caused by ampicilin- or penicillin-resistant strains of Hemophilus, or when patients are allergic to penicillin; in these instances, combination antimicrobial therapy must be given when bactericidal synergism can be demonstrated. Intensive management of complications caused by embolization is crucial to patient survival.
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PMID:Hemophilus endocarditis: new cases, literature review and recommendations for management. 30 87

Antibiotics were prescribed for 60% of 1538 patients who consulted a community care centre due to respiratory tract infections. Potential respiratory tract pathogens (betahaemolytic streptococci group A, C, G, Haemophilus influenzae, pneumococci) were isolated from almost half (46%) of the patients. The prescribing of antibiotics was correlated to the isolation of potentially pathogenic bacteria, except for patients with pharyngitis, sinusitis and bronchitis. Betahaemolytic streptococci group A were isolated from 14% of the patients. Recurrence of group A streptococcal infection occurred within 3 months in 24% of patients harbouring such bacteria at the first visit. Poststreptococcal subclinical acute glomerulonephritis (AGN) was diagnosed in 9 (4%) of 220 patients with group A streptococci. The patients with AGN had been treated with antibiotics significantly later than patients without signs of AGN.
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PMID:Respiratory tract infections at a community care centre--with emphasis on group A streptococci. 635 80