Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0348321 (
Haemophilus
)
15,372
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
Haemophilus
, Aggregatibacter, Cardiobacterium, Eikenella, Kingella
(HACEK) group genus
Eikenella
contained a single species,
Eikenella corrodens,
for many years. In November 2019,
Eikenella exigua
was described after recovery from a brain abscess and blood culture in Norway. Coincidentally, characterization of 22 Gram-negative bacteria resembling
Eikenella
from 17 Canadian patients had been underway. Seven isolates from five patients were conclusively identifiable as
E. corrodens
. One (
NML
120819) was deemed to represent a species of the genus
Eikenella
most closely related to
E. corrodens
. Fourteen isolates had 97.6 to 98.8% similarities to
E. corrodens
by 16S rRNA gene sequencing, forming three distinct groups by genome analyses. The largest contained ten anaerobic isolates from eight patients recovered from blood, brain, bone and other abscesses; upon re-evaluation, this group was found to be most consistent with
E. exigua
. A second facultatively anaerobic clade consisted of two ocular isolates from one patient and a sinus isolate from a second patient. The third taxon consisted of a single strictly anaerobic blood culture isolate. The novel taxa, like
E. corrodens
, were poorly reactive biochemically and difficult to discern from each other phenotypically and chemotaxonomically, including by cellular fatty acids. MALDI-TOF (Bruker) and whole-genome sequencing were used to further characterize isolates. Draft genomes for the strains had similar DNA G+C contents (55.38-58.53 mol%) while sizes varied from 1.82 Mb to 2.54 Mb. We propose here emendations of the genus
Eikenella
and the species
Eikenella exigua
, as well as describing
Eikenella halliae
sp. nov.
NML
130454
T
(=LMG 30894
T
=NCTC 14180
T
) and
Eikenella longinqua
sp. nov.
NML
02-A-017
T
(=LMG 30896
T
=NCTC 14179
T
), on the basis of these findings.
...
PMID:Description of
Eikenella halliae
sp. nov. and
Eikenella longinqua
sp. nov., derived from human clinical materials, emendation of
Eikenella exigua
Stormo
et al.
2019 and emendation of the genus
Eikenella
to include species which are strict anaerobes. 3230 76
