Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the present study the feed and water consumption and pharmacokinetic parameters of orally administered oxytetracycline were compared in clinically healthy pigs and in the same pigs following a challenge with Actinobacillus (Haemophilus) pleuropneumoniae toxins. Endobronchial challenge with A. pleuropneumniae toxins was accompanied by anorexia, increased lassitude, labored breathing, fever, and increased white blood cell counts. Pleuropneumonia was evident in all pigs on autopsy. Following the challenge, both feed and water consumption were markedly reduced. In contrast to recommendations in the literature, it is concluded that drugs should not be administered to pneumonic pigs via water. In healthy pigs the oral bioavailability of oxytetracycline (50 mg/kg), given on an empty stomach, was 4.8% and the elimination half-life (t1/2 beta) was 5.92 h. After challenge, the pigs showed great variation in oxytetracycline plasma concentrations. In addition, the mean computed elimination rate constant (beta), t1/2 beta, the area under the plasma concentration-time curve (AUC), and clearance in pneumonic pigs differed significantly (P less than .05) from the values found in healthy pigs. The elimination half-life (t1/2 beta), AUC, and volume of distribution (Vd area) were increased. In diseased pigs the mean of maximum plasma concentrations (.87 micrograms/ml) was reached after 7 h, in contrast to 1.74 h (1.87 micrograms/ml) in the healthy pigs.
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PMID:The influence of disease on feed and water consumption and on pharmacokinetics of orally administered oxytetracycline in pigs. 188 4

The prevalence and pathomorphology of gross lung lesions were studied in 855 slaughter weight pigs from 9 selected herds in south-eastern Norway. Pneumonic or pleuritic lesions were found in 84% of the lungs, ranging from 37% in the least affected herd to 97% in the one most affected. Bronchopneumonia indicative of a primary Mycoplasma hyopneumoniae infection was found in 70% of the lungs, ranging from 9% to 82% in the individual herds. The amount of bronchopneumonic lesions in individual lungs ranged from 0 to 69%, with an average of 7.8%. Pleuropneumonia indicative of Actinobacillus (Haemophilus) pleuropneumoniae infection was found in 29% of the lungs ranging from 0 in the least affected herd to 58% in the most affected. Diffuse pleuritis was found in 41% of the lungs and the prevalence ranged from 4% to 63%.
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PMID:An abattoir survey of pneumonia and pleuritis in slaughter weight swine from 9 selected herds. I. Prevalence and morphological description of gross lung lesions. 195 Aug 52