Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 92 patients (52 adults and 40 children) admitted to Kenyatta National Hospital in Nairobi, Kenya, with pyogenic meningitis were enrolled in a descriptive cross-sectional analysis of the bacteriology and sensitivity factors associated with this disease. In 75 cases (82%), cerebrospinal fluid cultures were bacteriologically positive. Common isolates included Streptococcus pneumoniae (45%), Neisseria meningitidis (14%), and Haemophilus influenzae (12%). Although all 3 of these isolates were responsive to chloramphenicol, 7% of Streptococcus pneumoniae and 15% of Neisseria menigitidis isolates were resistant to crystalline penicillin and 27% of Haemophilus influenzae isolates were resistant to ampicillin. Sensitivity of these 3 organisms to the third-generation cephalosporins (ceftazidime, cefotaxime, and ceftriaxone), a second-generation cephalosporin (cefuroxime), and augmentin was almost 100%; however, their use is limited by cost. On the basis of these findings, it is recommended that chloramphenicol and crystalline penicillin or ampicillin be initial blind therapy for adults and older children with pyogenic meningitis, while ampicillin and chloramphenicol should be used in preschool children.
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PMID:Bacteriology and sensitivity patterns of pyogenic meningitis at Kenyatta National Hospital, Nairobi, Kenya. 890 47

Four hundred and ninety nine children (aged between one month and five years) admitted with clinical features of meningitis were recruited in cross-sectional survey of bacterial meningitis in hospitals within Nairobi. Lumbar punctures were done on all of them and the cerebrospinal fluid (CSF) analysed bacteriologically and serologically for the common causative organisms. Two hundred and fifty (50.1%) cases were diagnosed clinically as having meningitis. Of these, 132 (52.8%) had turbid CSF specimens, while 118 (47.2%) were clear. When turbid CSF specimens were cultured, 83 (62.8%) yielded three common bacterial micro-organisms namely; Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae in that order of frequency. The implications of these findings in paediatric meningitis together with the drug sensitivity patterns is presented and discussed.
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PMID:Bacterial meningitis in children admitted in hospitals within Nairobi. 964 Aug 26