Gene/Protein Disease Symptom Drug Enzyme Compound
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The National Immunization Survey (NIS) is an ongoing survey to provide estimates of vaccination coverage levels among children aged 19-35 months in the United States, all 50 states, and selected urban areas. CDC implemented NIS in April 1994 as one element of the five-part Childhood Immunization Initiative (CII), a national strategy to achieve and maintain high vaccination levels among children during the first 2 years of life. NIS collects quarterly data from all 50 states, the District of Columbia, and 27 urban areas considered to be at high risk for undervaccination. This report provides NIS findings for July 1994-June 1995, which indicate that coverage levels for diphtheria and tetanus toxoids and pertussis vaccine (DPT), Haemophilus influenzae type b vaccine (Hib), poliovirus vaccine, and hepatitis B vaccine have met or exceeded the 1995 interim goals of the CII and that coverage for measles-mumps-rubella vaccines (MMR) is within 1 percentage point of the objective.
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PMID:National, state and urban area vaccination coverage levels among children aged 19-35 months--United States, July 1994-June 1995. 913 66

The Childhood Immunization Initiative (CII), a comprehensive response to under-vaccination among preschool-aged children, was initiated in the United States in 1993 (1). The goals of the CII were to eliminate by 1996 indigenous cases of diphtheria, tetanus (among children aged < 15 years), poliomyelitis, Haemophilus influenzae type b (Hib) invasive disease (among children aged < 5 years), measles, and rubella (1); reduce indigenous cases of mumps to < 1600; and increase vaccination coverage levels to > or = 90% among children aged 2 years for the most critical doses of each vaccine routinely recommended for children (except hepatitis B vaccine). This report presents provisional 1996 data about reported cases of selected vaccine-preventable diseases. In 1996, no cases of tetanus among children aged < 15 years or of polio caused by wild poliovirus were reported in the United States; the number of reported cases of indigenously acquired mumps was substantially below the disease-reduction target; and the numbers of reported cases of diphtheria, invasive Hib disease (among children aged < 5 years), rubella, and measles were at or near the lowest levels ever recorded and near the elimination targets.
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PMID:Status report on the Childhood Immunization Initiative: reported cases of selected vaccine-preventable diseases--United States, 1996. 923 76

To determine the current immunization recommendations of practicing pediatric nephrologists, a questionnaire was sent to the members of the North American Pediatric Renal Transplant Cooperative Society. Sixty-two percent of the centers responded. The results of the survey suggest that although consensus for approaching immunization does exist, recommendations do vary from center to center. Virtually all centers recommend standard vaccines [DTP, oral poliovirus (OPV), hepatitis B (Hep B), and Haemophilus influenzae B (Hib)] for their renal insufficiency and dialysis patients. Despite the fact that they are not infectious, standard killed vaccines (DTP, Hep B, Hib) are recommended less frequently for transplanted patients (86%) than their renal insufficiency (98%) and dialysis (near 100%) counterparts. Additionally, OPV and measles/mumps/rubella (MMR), both live viral vaccines, are rarely recommended post transplant. Almost 90% of centers recommend the use of influenza vaccine, while only 60% of centers recommend pneumococcal vaccine for children with renal disease. Over 70% of centers recommend the newly licensed varicella vaccine for patients on dialysis and those with renal insufficiency. Between 5% and 12% of centers recommend live viral vaccines, including OPV, MMR, and varicella vaccine, for immunosuppressed patients post renal transplant.
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PMID:Immunization practices in children with renal disease: a report of the North American Pediatric Renal Transplant Cooperative Study. 926 Feb 42

The OMP P5-homologous fimbriae of nontypeable Haemophilus influenzae (NTHi) are an adhesin and a virulence factor for otitis media in chinchilla models. We synthesized two peptides (LB1 and LB2) which incorporate determinants of the fimbrial subunit co-linearly synthesized with a "promiscuous" T-cell epitope from the fusion protein of measles virus. Sera obtained from immunized rabbits and chinchillas demonstrated significant reciprocal titers against both the homologous peptide and isolated fimbrial protein. Antisera also immunolabeled native fimbriae of whole unfixed NTHi. Immunization with LB1 or fimbrin resulted in elimination of NTHi from the chinchilla nasopharynx 2-3 weeks earlier than controls, respectively.
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PMID:Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla. 926 41

In an era that emphasizes the term "cost-effective," vaccines are the ideal solution to preventing disease at a relatively low cost to society. Much of the previous emphasis has been on childhood scourges such as measles, mumps, rubella, poliomyelitis, and Haemophilus influenzae type b. The concept of vaccines for fungal diseases has had less impact because of the perceived limited problem. However, fungal diseases have become increasingly appreciated as serious medical problems that require recognition and aggressive management. The escalation in the incidence and prevalence of infection has prompted a renewed interest in vaccine development. Herein, I discuss the most recent developments in the search for vaccines to combat fungal infections. Investigators have discovered several inert substances from various fungi that can mediate protection in animal models. The next challenge will be to find the suitable mode of delivery for these immunogens.
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PMID:Prospects for the development of fungal vaccines. 933 63

In 1996 there were 65,024 notifications to the National Notifiable Diseases Surveillance System. The record high number of Ross River virus infection notifications was of particular note. The highest rates were recorded in Western Australia, where an outbreak was documented in the South West, and in Queensland. Most cases occurred in the late summer and early autumn months. The number of measles cases has continued to fall markedly following the outbreak in 1993 and 1994. Rubella notifications also fell in 1996. The number of cases of pertussis remained at a similar level to that recorded in recent years, the highest notification rate being recorded for children under the age of one year. A peak in late 1996 marked a resurgence in the pertussis epidemic which has continued into 1997. Notifications of Haemophilus influenzae type b continued to decline reaching a record low rate of 0.3 notifications per 100,000 population. For the enteric diseases, the number of cases of campylobacteriosis rose, with an annual adjusted notification rate of 100.4 per 100,000 population; more notifications were received for this disease than for any other in 1996. The number of hepatitis A cases also rose relative to 1995. This is a reversal of the trend observed in recent years when the notification rate fell. The number of cases of salmonellosis and shigellosis remained stable. Notifications for chlamydial infection and gonococcal infection rose relative to 1995, whilst those for syphilis fell.
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PMID:Australia's notifiable diseases status, 1996. Annual report of the National Notifiable Diseases Surveillance System. 933 2

Since publication of the recommended childhood immunization schedule in January 1997, CDC's Advisory Committee on Immunization Practices (ACIP), the American Academy of Pediatrics (AAP), and the American Academy of Family Physicians (AAFP) have changed recommended ages for administration of measles-mumps-rubella vaccine (MMR) and poliovirus vaccines. In addition, these organizations have clarified recommendations for administration of MMR, varicella vaccine, and hepatitis B vaccine during the routine visit to health-care providers for adolescents aged 11-12 years; the interchangeability of the three licensed Haemophilus influenzae type b (Hib) vaccines for primary and booster vaccination; and the timing for the third dose of hepatitis B vaccine. This report presents the recommended childhood immunization schedule for 1998 and explains the changes that have occurred since publication of the last schedule. Detailed recommendations about the use of vaccines are available from the manufacturers' package inserts, the 1997 Red Book, or ACIP statements on specific vaccines.
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PMID:Recommended childhood immunization schedule--United States, 1998. 945 Jul 23

The tyrosine phosphatase IA-2 is a molecular target of pancreatic islet autoimmunity in type 1 diabetes. T-cell epitope peptides in autoantigens have potential diagnostic and therapeutic applications, and they may hold clues to environmental agents with similar sequences that could trigger or exacerbate autoimmune disease. We identified 13 epitope peptides in IA-2 by measuring peripheral blood T-cell proliferation to 68 overlapping, synthetic peptides encompassing the intracytoplasmic domain of IA-2 in six at-risk type 1 diabetes relatives selected for HLA susceptibility haplotypes. The dominant epitope, VIVMLTPLVEDGVKQC (aa 805-820), which elicited the highest T-cell responses in all at-risk relatives, has 56% identity and 100% similarity over 9 amino acids (aa) with a sequence in VP7, a major immunogenic protein of human rotavirus. Both peptides bind to HLA-DR4(*0401) and are deduced to present identical aa to the T-cell receptor. The contiguous sequence of VP7 has 75% identity and 92% similarity over 12 aa with a known T-cell epitope in glutamic acid decarboxylase (GAD), another autoantigen in type 1 diabetes. This dominant IA-2 epitope peptide also has 75-45% identity and 88-64% similarity over 8-14 aa to sequences in Dengue, cytomegalovirus, measles, hepatitis C, and canine distemper viruses, and the bacterium Haemophilus influenzae. Three other IA-2 epitope peptides are 71-100% similar over 7-12 aa to herpes, rhino-, hanta- and flaviviruses. Two others are 80-82% similar over 10-11 aa to sequences in milk, wheat, and bean proteins. Further studies should now be carried out to directly test the hypothesis that T-cell activation by rotavirus and possibly other viruses, and dietary proteins, could trigger or exacerbate beta-cell autoimmunity through molecular mimicry with IA-2 and (for rotavirus) GAD.
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PMID:T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents. 960 76

All nations that are part of the European Union share the same aim for the control and eradication of vaccine-preventable diseases. However, there are differences in child immunization strategies and schedules between nations, depending upon health care systems, immunization habits and epidemiology of infectious diseases. All nations immunize children against diphtheria, tetanus, poliomyelitis, measles, rubella and mumps. Immunization against pertussis, Haemophilus influenzae, hepatitis B and tuberculosis are not systematically applied.
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PMID:[Immunization schedule in the European Union]. 978 40

The goals of the Childhood Immunization Initiative (CII) for 1996 were to have > or =90% of children receive three or more doses of diphtheria and tetanus toxoids and pertussis vaccine/diphtheria and tetanus toxoids (DTP/DT), poliovirus vaccine, and Haemophilus influenzae type b vaccine (Hib) and one dose of measles-mumps-rubella vaccine, and for > or =70% of children to receive three or more doses of hepatitis B vaccine. The National Immunization Survey (NIS) was undertaken as part of the CII to monitor vaccination coverage levels for each state and for 28 urban areas. This report presents coverage estimates by race/ethnicity and poverty level for 1997 and compares coverage estimates for 1995 and 1997; the findings indicate improvements in vaccination coverage levels among children living below poverty level although these levels were lower than levels among children living at or above poverty level.
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PMID:Vaccination coverage by race/ethnicity and poverty level among children aged 19-35 months--United States, 1997. 983 73


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