Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0348321 (
Haemophilus
)
15,372
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Background:
Breast milk jaundice (BMJ) is the first cause of
neonatal jaundice
; however, its underlying mechanism is yet to be deciphered. We conducted a study to investigate intestinal flora in neonates with BMJ and used metabolomics to decipher the possible mechanisms by which intestinal flora induces jaundice.
Methods:
Microbiota collected from the feces of BMJ patients and jaundice-free breastfeeding newborns was used for 16S rRNA sequencing. In addition, differences in fecal metabolites were analyzed using gas chromatography mass spectrometry (GC/MS). The relationship between intestinal microbiota and the differences in fecal metabolites was then analyzed.
Results:
There was no significant difference in the richness and diversity of intestinal flora between BMJ and the control group; however, there were differences in the structure. At the phylum level, the relative abundance of
Firmicutes
was higher in the control group compared to the BMJ group, whereas
Proteobacteria
was higher in the infants with BMJ. Additionally, at the genus level, the relative abundance of
Haemophilus
was higher in the control group, whereas the relative abundances of
Escherichia, Morganella
, and
Rothia
were lower. More remarkably, the major differences in metabolites between the two groups were glyceric acid, succinic acid, and phenylalanine. Additionally, the abundance of
Escherichia
was positively correlated with succinic acid and cadaverine levels.
Conclusions:
The intestinal flora colonization status in BMJ patients is immature. This study reports for the first time that the study of intestinal flora, especially
Escherichia
, plays an important role in BMJ, and found that it may be associated with the regulation of succinic acid metabolic pathways.
...
PMID:Changes in Intestinal Flora and Metabolites in Neonates With Breast Milk Jaundice. 3247 13
