Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0348321 (Haemophilus)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chlamydial conjunctivitis was diagnosed by direct immunofluorescent monoclonal antibody staining of conjunctival smears in 46 of 100 consecutive neonates with conjunctivitis. The remaining 54 infants had bacterial conjunctivitis most commonly caused by Staphylococcus, Streptococcus, and Haemophilus species. A comparison of the direct test with chlamydial cultures demonstrated a sensitivity of 100% and a specificity of 94%, whereas Giemsa stain had a sensitivity of 42% and a specificity of 98%. Nineteen percent of infants treated with oral erythromycin for chlamydial infections in accordance with Centers for Disease Control guidelines had clinical and laboratory evidence of persistent chlamydial conjunctivitis. We conclude that Chlamydia trachomatis is a major cause of neonatal conjunctivitis that can be effectively and rapidly diagnosed by direct immunofluorescent monoclonal antibody staining of conjunctival smears. Further evaluation of treatment regimens appears to be warranted.
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PMID:Assessment of neonatal conjunctivitis with a direct immunofluorescent monoclonal antibody stain for Chlamydia. 242 18

Chlamydial conjunctivitis was diagnosed in 46 of 100 infants less than two months old presenting with conjunctivitis. Streptococcus, Staphylococcus, and Hemophilus species were most frequently identified in the remainder. All infants with chlamydial conjunctivitis were black and were born by vaginal delivery (P less than 0.001). Average age at presentation was 13 days for chlamydial and 21 days for other causes of bacterial conjunctivitis (P less than 0.001) with symptoms present an average of five to six days prior to presentation. There was no statistically significant difference in sex, birthweight, APGAR scores, bilaterality, fever, or prophylactic drops administered. Mothers of infants with chlamydial conjunctivitis averaged 19.5 years old versus 23.0 for the bacterial group (P less than 0.001). There was no statistically significant difference in past obstetrical or sexually transmitted disease history. Persistent chlamydial conjunctivitis following a two-week course of oral erythromycin as recommended by Centers for Disease Control was documented in 19% of patients with chlamydial infection.
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PMID:Epidemiology of neonatal conjunctivitis. 370 18