Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0345904 (liver cancer)
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Human Gene/Protein
LOC100129335 11.0
DNM1P35 11.0
HCCA2 protein 11.0
Zinc finger RNA binding protein 11.0
SNRNP27 11.0
GLS2 protein 11.0
Chloride intracellular channel protein 2 11.0
HCC 11.0
TMEM82 11.0
SEC13-like 1 isoform 11.0
zinc finger protein 224 11.0
Bcl-2 related ovarian killer 11.0
chaperonin 10-related protein 11.0
ADAMTS9 protein 11.0
MRPS18A 11.0
Glutathione S-transferase A3 11.0
HCCA2 11.0
RNA-binding motif protein 43 11.0
SCAN domain containing 3 11.0
HCAP1 10.4
SETD3 protein 10.0
LRP-DIT 10.0
SERPINA11 10.0
Mitochondrial trans-2-enoyl-CoA reductase 10.0
FAM84A protein 10.0
C10orf91 10.0
PBX3 protein 10.0
TIGD5 10.0
LAMC1 protein 10.0
ZNF223 10.0
Mrps18a 10.0
JTV1 10.0
OR4F3 10.0
guanine nucleotide binding protein gamma 3 10.0
hepatocellular carcinoma suppressor 1 10.0
Astrotactin 1 10.0
deubiquitinating enzyme 1 10.0
rho family, small GTP binding protein Rac1 10.0
HCC5 10.0
ZFP276 10.0
TRMT11 10.0
FAM9C 10.0
DLC1 protein 9.7
Uridine-cytidine kinase 2 9.4
ZNF484 9.4
RACGAP1P 9.4
SRRD 9.4
Acetyl-CoA synthetase 2 9.4
OLFML2A 9.4
RCOR3 9.4
SMC4 protein 9.4
KIF18A protein 9.4
RAD54 homolog B 9.4
Endosulfine alpha 9.4
EIF3S2 9.4
17beta-HSD type 12 9.4
TDRD4 9.4
AFMID 9.4
KIAA1114 9.4
H2.0-like homeobox 1 9.4
Zinc finger protein 143 9.4
SARA1 9.4
MPHOSPH6 9.4
HCDH 9.4
H2AFV 9.4
Mahlavu hepatocellular carcinoma 9.4
HCCS1 9.4
ZNF689 9.4
tribbles homolog 2 9.4
MAGEE1 9.4
protein tyrosine phosphatase receptor type F 9.4
DLC2 9.3
Hyccin 9.2
RFTN1 9.0
FAM84A 9.0
HUEL 9.0
F-box protein 31 9.0
GXIIB 9.0
High mobility group AT-hook 1 9.0
sideroflexin 2 9.0
more...
Disease
liver cancer 11.0
HCC 11.0
HC/HCC 11.0
liver cancer 11.0
Primary liver cancer 10.3
Malignant neoplasm of trachea, bronchus and lung 10.0
virus related cancer 10.0
Hepatobiliary neoplasms 10.0
Metastasis to spleen 9.4
hepatocholangiocarcinoma 9.1
Fibrolamellar hepatocellular carcinoma 9.1
Bile duct necrosis 9.0
Hepatocarcinogenesis 8.6
Hepatocellular carcinoma 8.5
pediatric liver cancer 8.4
Other liver diseases 8.4
Occupational Cancer 8.3
MRX34 8.2
Chronic viral hepatitis 8.1
FHL4 8.0
Liver fluke infection 7.9
Cervix uteri 7.9
LQT6 7.9
hepatocellular carcinoma 7.8
nasal neoplasm 7.7
liver scarring 7.6
Chronic liver disease and cirrhosis 7.6
Radiation-induced liver disease 7.6
Decompensated cirrhosis 7.4
Ampullary carcinoma 7.3
digestive system cancer 7.3
Chronic hepatitis B 7.3
Hereditary tyrosinemia type I 7.3
Bile duct cancer 7.2
Hepatic actinomycosis 7.2
nasopharyngeal neoplasm 7.2
LEL 7.2
Bonnier 7.0
PCWH 7.0
hepatic neoplasm 7.0
Chronic infection 7.0
MILS 6.9
Lorain 6.9
Stenotrophomonas maltophilia infection 6.9
cholemia 6.9
Portal vein occlusion 6.9
Hepatic hemangioma 6.8
Alveolar echinococcosis 6.7
Cholangiocarcinoma 6.7
cirrhosis 6.7
Cholangiocarcinoma 6.7
OIC 6.6
HVDRR 6.6
Cirrhosis 6.6
Multiple cancer 6.6
CARASIL 6.5
Chronic hepatitis C 6.5
upper GI cancer 6.4
biliary neoplasm 6.4
hepatoblastoma 6.4
FHL3 6.3
HFH 6.3
hepatitis B 6.3
Alcoholic liver disease 6.2
Tumor morphology 6.2
APUDoma 6.2
hepatic adenoma 6.2
lymphatic cancer 6.1
Focal nodular hyperplasia 6.1
chronic liver disease 6.1
viral hepatitis 6.1
alcoholic fatty liver 6.1
INFECTION 6.1
HEP 6.1
chronic hepatitis 6.0
Peliosis hepatis 6.0
LADD 5.9
Demyelinating Polyneuropathy 5.9
tyrosinosis 5.9
liver fibrosis 5.9
more...
Symptom
liver pain 8.0
decreased skin turgor 7.9
Chills and fever 7.7
No adverse effect 4.3
hepatomegaly 4.3
right upper quadrant pain 4.2
left upper quadrant pain 4.0
generalized pain 3.4
Spots 3.2
ACHE 3.2
abdominal discomfort 3.1
dark urine 2.9
lassitude 2.9
leg edema 2.6
epigastric pain 2.6
Tenderness 2.5
hypoproteinemia 2.5
decreased appetite 2.4
Scratch 2.4
abdominal fullness 2.4
tenesmus 2.1
stomach pain 2.1
eds 2.0
pleuritic chest pain 1.8
halitosis 1.8
chills 1.8
splenomegaly 1.8
cachexia 1.7
acute abdominal pain 1.7
asthenia 1.7
exhaustion 1.6
nausea 1.6
anorexia 1.5
abdominal pain 1.5
DNA marker 1.2
nausea and vomiting 1.1
Stiffness 1.1
otalgia 1.1
cancer pain 1.0
bone pain 1.0
tense 0.9
vomiting 0.9
night sweats 0.8
starvation 0.7
masculinization 0.7
Wind 0.7
Sedation 0.6
Ill 0.6
Neuropathic pain 0.6
hepatosplenomegaly 0.5
skin damage 0.5
hemoptysis 0.5
overweight 0.4
despair 0.4
menopausal symptoms 0.4
stigma 0.3
bloating 0.3
fatigue 0.3
diarrhea 0.2
oliguria 0.2
Depressive symptoms 0.1
chronic cough 0.0
leg pain 0.0
fever of unknown origin 0.0
flushing -0.0
acidity -0.0
stridor -0.2
collapse -0.2
pallor -0.3
constipation -0.3
shortness of breath -0.3
ENT -0.3
pain -0.5
HSA -0.5
discomfort -0.6
cough -0.7
chest pain -0.7
discomfort -0.7
dyspnea -0.7
respiratory distress -0.9
more...
Drug
Livact 9.4
Edotecarin 9.4
Monoammonium glycyrrhizinate 9.0
Smancs 9.0
Peretinoin 8.7
Nexavar 7.9
Sorafenib 7.8
Doxifluridine 7.7
Zedoary 7.7
Lipiodol 7.6
Bear bile 7.6
Mangafodipir trisodium 7.4
Semaxanib 7.3
BZQ 7.2
Romet 7.0
1,2,4-Triazole 6.8
Telbivudine 6.7
Sonazoid 6.7
Forodesine 6.5
Purvalanol 6.5
Gd-BOPTA 6.2
Maltitol 6.2
Nitisinone 6.1
Butaprost 6.1
Neamine 6.0
Resovist 5.8
Entecavir 5.8
Entecavir 5.8
Levovist 5.8
Wellferon 5.5
Iron dextran 5.5
Gadoteridol 5.1
Intron A 5.0
Axitinib 5.0
Intron A 5.0
Emodin 5.0
Tipifarnib 4.9
Gelfoam 4.7
Emodin 4.7
GEO 4.6
Compound 19 4.6
ADM 4.5
Pirarubicin 4.5
Sodium thiosulfate 4.4
Ddc 4.4
Arsenic trioxide 4.4
Novantrone 4.4
Compound 16 4.3
Erlotinib 4.3
Verteporfin 4.3
CMX 4.2
Compound 18 4.2
Romidepsin 4.2
Intron A 4.2
Spiegel 4.2
Pirfenidone 4.1
Swertia 4.1
Adefovir dipivoxil 4.1
CTM 4.1
Thioridazine 4.1
Dimethylformamide 4.1
Safflower 4.1
Celebrex 4.1
Compound 9 4.1
Adriamycin 4.0
Pertuzumab 4.0
Vandetanib 3.9
PNT 3.9
Indocyanine green 3.9
Vitamin K2 3.8
Senna 3.8
Portal 3.8
Senna 3.7
CTM 3.7
Panitumumab 3.7
Carbidopa 3.7
2-Methoxyestradiol 3.7
MTC 3.6
Gefitinib 3.6
PMEA 3.5
more...
Enzyme
TACE 7.7
L-fucose dehydrogenase 7.4
aryl sulfotransferase IV 7.1
trihydroxycoprostanoyl-CoA oxidase 6.6
ceramide synthetase 6.4
glycine N-methyltransferase 6.0
5beta-reductase 5.8
methionine adenosyltransferase 5.3
site-1 protease 5.2
phosphatidylethanolamine N-methyltransferase 5.2
fumarylacetoacetate hydrolase 5.2
ethanolamine kinase 5.1
GSase 5.1
DHAD 5.1
histone-lysine N-methyltransferase 5.0
phosphatidylinositol-4,5-bisphosphate 3-kinase 5.0
PMT 4.7
retinyl ester hydrolase 4.7
heparitinase I 4.6
galactosylhydroxylysyl glucosyltransferase 4.6
Omi/HtrA2 4.6
gamma-glutamyl transpeptidase 4.6
nicotinamide N-methyltransferase 4.5
caspase-9 4.4
AST 4.3
DAP II 4.3
HK2 4.2
site-1 protease 4.2
caspase-7 4.2
caspase-8 4.2
ribose-5-phosphate isomerase 4.2
4-hydroxyphenylpyruvate dioxygenase 4.2
sterol carrier protein 4.2
phosphofructokinase 1 4.2
caspase-7 4.2
STK11 4.2
eEF2 kinase 4.2
EC 2.7.7.9 4.1
acyl-CoA oxidase 4.1
O-GlcNAc transferase 4.1
SOR 4.1
dynein ATPase 4.0
alanine aminotransferase 4.0
PARP 4.0
caspase-3 3.9
aspartate aminotransferase 3.8
GMP synthetase 3.8
lipoate acetyltransferase 3.8
calpain 3 3.8
AGT 3.8
N-acetylglucosaminyltransferase V 3.7
protoporphyrinogen oxidase 3.7
lecithin:retinol acyltransferase 3.7
CD13 3.7
oxidosqualene cyclase 3.6
glucose-6-phosphatase 3.5
alpha-L-fucosidase 3.5
nicotinamide phosphoribosyltransferase 3.5
histone demethylase 3.5
AMPK 3.5
NQO2 3.4
luciferase 3.4
tetanus neurotoxin 3.4
microsomal epoxide hydrolase 3.4
argininosuccinate lyase 3.4
HCS 3.4
cdc2 3.3
pregnancy-associated plasma protein-A 3.3
AAE 3.3
acylphosphatase 3.2
type III procollagen 3.2
inositol 3-kinase 3.2
methylthioadenosine phosphorylase 3.2
AMP-activated kinase 3.2
phosphoinositide 3-kinase 3.2
sphingomyelin synthase 3.2
glutaminase 3.1
estrogen sulfotransferase 3.1
glutathione S-transferase 3.1
CYP7A1 3.1
more...
Compound
Ingenol 3,20-dibenzoate 11.0
C20H21NO5 11.0
C20H21NO5 11.0
C20H21NO5 11.0
C20H21NO5 11.0
C20H21NO5 11.0
C20H21NO5 11.0
C16H20O5 10.0
C21H20N2O2 10.0
1-dotriacontanol 10.0
C14H16N2O4S 10.0
C19H18O7 10.0
3-Hydroxybiphenyl 9.4
Papaverinol 9.4
Longikaurin A 9.4
Columbamine 9.4
C8H9NO2 9.2
furostan-3,26-diol 9.0
Clerosterol 9.0
C16H14O3 9.0
1,10-decanedithiol 8.9
C8H8O5 8.7
C8H8O5 8.7
C8H8O5 8.7
C8H8O5 8.7
C8H8O5 8.7
1H-indole-2-carbohydrazide 8.7
C8H8O5 8.7
C8H8O5 8.7
Solasonine 8.6
Hellebrigenin 8.4
3-chloro-1-butene 8.4
Vernolide 8.4
Gartanin 8.4
Bromopyruvic acid 8.4
C8H8O5 8.4
C8H8O5 8.4
Tamarixetin 8.4
Wuweizisu C 8.4
Anthraflavic acid 8.4
Dioxadet 8.2
C8H8O5 8.2
C8H8O5 8.2
formaldehyde hydrazone 8.0
Ginkgolide C 8.0
methyl 3,4,5-trihydroxybenzoate 8.0
5,7-dibromo-8-quinolinol 8.0
C8H8O5 7.9
Megestrol 7.9
PHPS 7.9
Veratramine 7.9
Hematein 7.9
Resibufogenin 7.9
Myrtenal 7.7
Bufotalin 7.7
Myrtenal 7.7
Tubeimoside I 7.7
TACE 7.7
C8H8O5 7.6
C20H24N2O4 7.4
2-(methylthio)ethanol 7.4
Citraconic anhydride 7.3
Glycochenodeoxycholic acid 7.2
Sinensetin 7.2
TF2B 7.1
Divinyl sulfone 7.1
Ovatodiolide 7.1
Ginkgolide C 7.1
Neamine 7.1
WY-14,643 7.1
Lariciresinol 7.0
5-hydroxyhexanoic acid 7.0
Oltipraz 7.0
Ailanthone 6.9
Doxercalciferol 6.9
5-chloro-7-iodo-8-quinolinol 6.9
Deoxyelephantopin 6.9
Moxestrol 6.9
4-hydrazinobenzoic acid 6.9
Cinchonine 6.9
more...