Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
HCC 2985
Sep 986
Mol 778
p53 528
alpha-fetoprotein 357
caspase-3 325
AFP 267
Bcl-2 250
catenin 250
AKT 235
Axin 202
interferon 200
mTOR 199
insulin 189
surface antigen 188
PI3K 186
albumin 179
NMR 160
p21 156
ERK 149
cytokine 141
MAPK 131
vascular endothelial growth factor 126
IFN 123
cyclin D1 122
MRI 121
STAT3 119
E-cadherin 118
cage 113
endoplasmic reticulum 110
TNF 105
CD133 105
ROS 104
TNM 102
PLC 98
VEGF 94
caspase-9 93
UTR 93
JNK 90
histone 90
proliferating cell nuclear antigen 88
PARP 88
aspartate aminotransferase 88
IL-6 87
tumor necrosis factor 85
tyrosine kinase 84
p38 84
serum albumin 83
cytochrome c 82
GSH 82
ATP 80
TACE 80
c-Myc 80
alanine aminotransferase 79
collagen 79
ERK1 78
caspase-8 77
ACS 74
Alpha-fetoprotein 74
PEG 73
annexin V 72
alkaline phosphatase 71
EGFR 70
MMP-9 69
epidermal growth factor receptor 68
CD8 67
c-myc 65
gut 62
superoxide dismutase 58
AST 58
CCK 57
ubiquitin 56
p27 56
survivin 56
prothrombin 55
CD44 55
matrix metalloproteinase 54
PTEN 54
N-cadherin 53
kit 53
estrogen receptor 53
PD-L1 52
MMP-2 52
CEA 52
beta-catenin 52
MEK 52
Rho 51
CD4 51
vimentin 50
catalase 50
glutathione S-transferase 50
Ki-67 49
ras 49
p65 49
nuclear receptor 48
PD-1 47
hepatocyte growth factor 46
LC3 46
EMT 46
Fas 46
GST 45
glycoprotein 45
cytochrome P450 45
proteasome 45
hemochromatosis 44
histone deacetylase 44
IL-10 44
extracellular signal-regulated kinase 43
cytochrome 43
interleukin-6 43
COX-2 42
protein kinase B 42
lectin 42
MYC 41
carcinoembryonic antigen 40
polypeptide 39
signal transducer and activator of transcription 3 39
YAP 37
fused 37
tumour suppressor 37
CTNNB1 37
cyclin 36
cytokeratin 19 36
RhoA 36
xenobiotic 36
c-Jun 36
ferritin 36
HNE 35
fibronectin 35
CD90 35
IL-8 34
thymus 34
She 34
MMP9 34
SMA 34
P-glycoprotein 33
cyclin E 33
MMP2 33
p62 33
AMPK 33
lactate dehydrogenase 32
asialoglycoprotein receptor 32
Yes 32
Mcl-1 32
chemokine 32
inducible nitric oxide synthase 32
peroxisome proliferator-activated receptor 32
glypican 31
Vimentin 31
non-Hodgkin's lymphoma 31
threonine 31
TEM 31
ADM 31
cyclin A 31
AS1 31
cyclin B1 30
TOF 30
phosphatase 30
lymphoid 30
Cyclin D1 29
more...
Disease
liver cancer 15188
liver cancer 11512
hepatocellular carcinoma 7544
cancer 6595
tumor 4880
HCC 2985
cirrhosis 2024
hepatitis B 1391
Hepatocellular carcinoma 1132
carcinogenesis 801
liver disease 798
hepatitis C 683
tumorigenesis 672
tumor growth 667
carcinoma 667
breast cancer 634
chronic hepatitis 622
lung cancer 563
hepatitis 528
gastric cancer 419
metastases 418
tumor progression 353
colorectal cancer 336
chronic liver disease 295
colon cancer 287
virus infection 274
diabetes 261
viral hepatitis 260
obesity 250
pancreatic cancer 248
liver fibrosis 228
fatty liver 227
prostate cancer 208
leukemia 199
melanoma 173
MCF 169
adenocarcinoma 163
cervical cancer 158
liver metastases 145
esophageal cancer 129
alcoholic fatty liver 118
esophageal cancer 114
hepatoblastoma 108
ovarian cancer 104
bladder cancer 99
infectious diseases 94
lymphoma 93
HIV 92
metabolic syndrome 88
Primary liver cancer 86
Nonalcoholic fatty liver 85
GSH 82
acute hepatitis 81
portal hypertension 81
renal cancer 81
type 2 diabetes 70
Chronic hepatitis B 66
arterial embolization 63
hemangioma 61
hypertension 61
alcoholism 60
adenoma 59
skin cancer 58
hemochromatosis 58
West 57
renal cell carcinoma 56
chronic active hepatitis 54
Hodgkin's disease 54
rectal cancer 53
squamous cell carcinoma 53
aggressiveness 52
Cirrhosis 51
thyroid cancer 50
alcohol abuse 50
primary tumor 49
tumor initiation 48
non-small cell lung cancer 48
Cholangiocarcinoma 47
EMT 46
tumor angiogenesis 46
cardiovascular disease 46
solid tumor 45
Infection 45
Chronic infection 44
Cholangiocarcinoma 44
endometrial cancer 44
ischemia 43
multiple myeloma 43
DDP 42
sarcoma 42
gastrointestinal cancer 41
iron overload 39
Chronic hepatitis C 39
glioma 39
glioblastoma 37
AIDS 37
angiosarcoma 36
non-Hodgkin's lymphoma 36
lung carcinoma 36
alcoholic cirrhosis 35
stroke 34
anemia 33
neoplastic transformation 33
TEM 33
osteosarcoma 32
chronic disease 32
SCID 32
TEM 31
cold 31
cholestasis 31
AS1 31
dysplasia 31
gallbladder cancer 30
viremia 30
retinoblastoma 30
lung metastases 29
Best 29
hepatitis A 29
obstructive jaundice 28
myocardial ischemia 28
hepatic encephalopathy 28
B-cell lymphoma 28
Kaposi's sarcoma 27
Nasopharyngeal carcinoma 27
SEM 26
MTS 26
immunodeficiency 25
liver abscess 25
depression 25
gallstones 25
Hepatocarcinogenesis 24
malnutrition 24
HEP 23
esophageal varices 23
Alzheimer's disease 23
acute myeloid leukemia 23
thrombocytopenia 23
primary biliary cirrhosis 23
heart failure 22
HGF 22
schistosomiasis 22
cancer recurrence 22
Epstein 22
tuberculosis 22
APC 22
Blocking 22
aggression 21
hepatic neoplasm 21
NS3 21
hereditary hemochromatosis 21
NOD 21
uterus 21
suicide 21
myocardial infarction 20
Echinococcus 20
chemical carcinogenesis 20
brain cancer 20
oral cancer 19
residual disease 19
cholangitis 19
more...
Symptom
pain 88
hepatomegaly 53
abdominal pain 41
nausea 34
diarrhea 32
fatigue 30
vomiting 28
anesthesia 22
exhaustion 20
starvation 20
anorexia 19
overweight 17
splenomegaly 16
collapse 12
nausea and vomiting 10
epigastric pain 10
cachexia 9
dyspnea 8
Ill 8
stigma 8
weakness 7
acidity 7
discomfort 7
cough 7
chills 7
abdominal discomfort 7
discomfort 7
right upper quadrant pain 6
headache 6
respiratory distress 5
analgesia 5
chest pain 5
asthenia 4
hemoptysis 4
seizures 4
constipation 4
flushing 3
acute abdominal pain 3
cancer pain 3
back pain 3
hepatosplenomegaly 3
No adverse effect 3
hypoproteinemia 3
bone pain 3
decreased appetite 3
angina 3
shortness of breath 2
Wind 2
masculinization 2
Spots 2
ENT 2
hypothermia 2
leg edema 2
tense 2
eds 2
despair 1
tremor 1
acute stress 1
arthralgia 1
otalgia 1
oliguria 1
pallor 1
abdominal fullness 1
paresis 1
fever of unknown origin 1
regurgitation 1
HSA 1
acute pain 1
halitosis 1
skin damage 1
hemiplegia 1
myalgia 1
Chills and fever 1
dark urine 1
functional recovery 1
decreased skin turgor 1
Sedation 1
Neuropathic pain 1
Scratch 1
agitation 1
Tenderness 1
apathy 1
ACHE 1
lethargy 1
menopausal symptoms 1
bloating 1
night sweats 1
generalized pain 1
Depressive symptoms 1
lassitude 1
pleuritic chest pain 1
stridor 1
chronic cough 1
liver pain 1
leg pain 1
stomach pain 1
dizziness 1
syncope 1
DNA marker 1
spasticity 1
left upper quadrant pain 1
tenesmus 1
sleepiness 1
Stiffness 1
Drug
Sorafenib 161
ROS 104
lysine 77
Lipiodol 75
Monit 40
ROC 40
Adriamycin 36
ADM 35
Portal 27
caffeine 23
IL-2 23
vitamin E 21
ABC 21
ascorbate 19
Cardiovasc 19
GEO 18
Albumin 18
Ethanol 16
Arsenic trioxide 13
HCH 13
Nexavar 12
IFN-gamma 12
NADH 11
ENT 10
MRC 9
Gelfoam 9
ADR 9
CTX 9
Sonazoid 8
MAP 8
lactose 8
G418 7
Emodin 7
CSF 7
CTX 7
Gefitinib 7
CTX 7
Levovist 7
DNase I 7
Erlotinib 7
Emodin 7
Retinoic acid 7
Leaf 7
EE2 7
Biopolymers 7
Mutagen 7
Gel 7
Estrogens 6
niacin 6
ZnO 6
Entecavir 6
Docetaxel 6
Taxol 6
ALA 6
citric acid 6
Entecavir 6
Alliance 5
uPA 5
Vitamin A 5
EPA 5
HCG 5
EPI 5
CCL 5
Dermatol 5
CAM 4
Fraction 4
CTC 4
PMEA 4
Herceptin 4
Indocyanine green 4
CTC 4
AGG 4
Vitamin E 4
Telbivudine 4
Glycyrrhiza 4
Parkin 4
Parkin 4
Fructose 4
Dakar 4
Gelatin 4
Bifidobacterium 4
Angiotensin II 4
Gd-BOPTA 4
Ginseng 4
Asn 4
Doxifluridine 4
Glutathione 4
Nitric Oxide 4
APD 3
Oxaliplatin 3
SiO2 3
Spectrum 3
Cetuximab 3
Galactose 3
Fluorescein 3
Vitamin K 3
Indomethacin 3
TAC 3
VCR 3
NAG 3
Nephron 3
Norplant 3
Fragment 3
Clofibrate 3
MTC 3
NVP 3
TiO2 3
PDL 3
Kenyan 3
BTC 3
Resovist 3
Acacia 3
TAT 2
CTM 2
Smancs 2
Everolimus 2
Spiegel 2
Serum albumin 2
Novantrone 2
Bevacizumab 2
Growth hormone 2
Taxotere 2
Meth 2
Raloxifene 2
Pirfenidone 2
BoNT/A 2
Paraffin 2
Intron A 2
Aloe 2
Intron A 2
Senna 2
Omeprazole 2
Lovastatin 2
RFP 2
Growth hormone 2
Mangafodipir trisodium 2
Cremophor EL 2
PTH 2
THF 2
PTC 2
Irinotecan 2
Senna 2
ICI 2
CoCl2 2
CTM 2
Itraconazole 2
R1881 2
Activin 2
Axitinib 2
Bayer 2
Thioridazine 2
Swertia 2
Compound 9 2
Butaprost 2
-deoxyadenosine 2
CTA 2
AraC 2
Verteporfin 2
Leucovorin 2
PMPA 2
more...
Enzyme
ERK 349
mitogen-activated protein kinase 335
caspase-3 246
alanine aminotransferase 207
luciferase 192
aspartate aminotransferase 146
focal adhesion kinase 144
protein kinase 129
gamma-glutamyl transpeptidase 102
PARP 102
glutathione S-transferase 92
TACE 80
ACS 75
caspase-9 74
MEK 73
alkaline phosphatase 71
superoxide dismutase 69
caspase-8 61
catalase 61
AST 57
AMP-activated protein kinase 51
proteasome 45
cdc2 40
reverse transcriptase 36
AMPK 36
P-glycoprotein 34
lactate dehydrogenase 34
AMPK 33
protein kinase C 31
ATPase 30
glutathione peroxidase 28
phosphatidylinositol 3-kinase 28
RNA polymerase 27
GSK 26
phosphoinositide 3-kinase 25
APC 23
CD13 22
peroxidase 21
urokinase-type plasminogen activator 19
topoisomerase 19
calcineurin 18
acetylcholinesterase 18
thymidine kinase 17
glucose-6-phosphatase 17
NQO1 16
cholinesterase 15
RNase 15
trypsin 15
topoisomerase 15
IKK 15
DNA methyltransferase 14
CYP3A4 13
methionine adenosyltransferase 13
aldehyde dehydrogenase 13
RNase 13
collagenase 12
aldehyde dehydrogenase 11
aldehyde dehydrogenase 11
aldehyde dehydrogenase 11
demethylase 11
MDR 11
aldehyde dehydrogenase 11
cathepsin B 11
MMP 10
pyruvate kinase 10
DNA polymerase 10
glyceraldehyde-3-phosphate dehydrogenase 10
glutathione reductase 10
peroxiredoxin 9
granzyme B 9
transcriptase 9
NADPH oxidase 9
hexokinase 9
glucose-6-phosphate dehydrogenase 9
NADPH oxidase 9
NO synthase 9
glyceraldehyde-3-phosphate dehydrogenase 9
pyruvate dehydrogenase 8
glutamine synthetase 8
caspase-7 8
acyl-CoA oxidase 8
caspase-7 8
phosphoenolpyruvate carboxykinase 8
glutaminase 8
prolyl hydroxylase 7
glyceraldehyde-3-phosphate dehydrogenase 7
beta-galactosidase 7
alcohol dehydrogenase 7
protein phosphatase 2A 7
ceruloplasmin 7
ACE 7
MAP 7
glyceraldehyde-3-phosphate dehydrogenase 7
thioredoxin reductase 7
PDK1 7
caspase-1 7
pyruvate dehydrogenase 7
glyceraldehyde-3-phosphate dehydrogenase 7
pyruvate dehydrogenase 7
ribonuclease 6
ribonuclease 6
ornithine decarboxylase 6
phosphodiesterase 6
CPR 6
arginase 6
hyaluronidase 5
PMT 5
acid phosphatase 5
histone demethylase 5
lysozyme 5
matrix metalloproteinase 9 5
HK2 5
lysyl oxidase 5
glycine N-methyltransferase 5
plasmin 5
polo-like kinase 1 5
phosphoenolpyruvate carboxykinase 5
phosphoenolpyruvate carboxykinase 5
AGT 5
thrombin 5
fumarylacetoacetate hydrolase 5
diaphorase 5
endonuclease 5
complex I 5
soluble epoxide hydrolase 5
CPT 5
enolase 4
Omi/HtrA2 4
neuraminidase 4
hyaluronidase 4
thymidylate synthase 4
MMP-3 4
CYP7A1 4
adenylate cyclase 4
phosphatidylethanolamine N-methyltransferase 4
ATP synthase 4
elastase 4
matrix metalloproteinase 2 4
TSA 4
firefly luciferase 4
aldose reductase 4
prostate-specific antigen 4
STK11 4
microsomal epoxide hydrolase 4
phosphorylase 4
histone acetyltransferase 4
O-GlcNAc transferase 4
tissue plasminogen activator 4
alpha-L-fucosidase 4
methylenetetrahydrofolate reductase 3
lipoxygenase 3
cathepsin D 3
CD10 3
carboxylesterase 3
PRE 3
type III procollagen 3
methylenetetrahydrofolate reductase 3
dihydropyrimidine dehydrogenase 3
dihydropyrimidine dehydrogenase 3
guanylate cyclase 3
more...
Compound
DNA 1320
Dec 996
Clin 654
oxygen 380
MTT 373
water 360
ethanol 241
glucose 225
iron 165
aflatoxin B1 161
PEG 127
TNF 105
calcium 105
TNM 102
MDA 101
Pac 100
methionine 99
PEG 94
5-FU 93
phosphate 92
galactose 91
lysine 88
sodium 86
GSH 85
GSH 85
ATP 80
TACE 80
tyrosine 78
serine 76
bromide 76
ACS 74
ACS 74
Adriamycin 73
DEN 71
copper 68
iodine 68
cysteine 67
hydrogen 64
acetate 62
arginine 58
zinc 55
MEK 54
nitrogen 52
nitric oxide 51
DDP 48
adenosylmethionine 48
ADR 48
silver 47
selenium 44
threonine 40
His 40
retinoic acid 39
MMC 39
sulfate 39
vinyl 38
alanine 38
leucine 36
TEM 35
N-acetylcysteine 34
urea 34
pyrimidine 33
pyrimidine 33
ethyl acetate 32
Vimentin 31
hyaluronic acid 30
TOF 30
Curcumin 29
salt 29
Insulin 28
ASA 28
PEI 28
PEI 28
Phe 28
methanol 28
pyrene 27
CCl4 26
MTS 26
glutamine 26
vitamin D 26
Estrogen 25
CO2 25
nicotinamide 24
chloroform 23
caffeine 23
aldehyde 23
acetic acid 23
DTPA 23
25-hydroxycholecalciferol 23
HEP 23
NAD 22
CCC 21
TCA 21
ADP-ribose 20
ammonia 20
H2O2 20
CCC 20
Asp 20
Estrogen 19
retinol 19
creatinine 19
Panam 19
dUTP 19
manganese 18
GTP 18
SDS 18
acridine 18
Tamoxifen 17
chalcone 17
Resveratrol 17
diacetate 17
benzene 17
Tamoxifen 17
cadmium 17
nickel 17
AAF 17
carbonate 16
PLA 16
DPPH 16
8-OHdG 16
NAD 16
GPT 16
proline 16
potassium 16
fluorine 15
ADP 15
Cardiol 15
gallic acid 15
ALP 15
boron 15
cAMP 15
GlcNAc 15
Histone 14
glycerol 14
formaldehyde 14
Hoechst 33342 14
aldehyde 14
phosphorus 13
glutamate 13
3TC 13
piperazine 13
homocysteine 13
CAT 13
pyridine 13
HCA 13
acetone 13
DDT 13
Paclitaxel 13
Ile 13
CAT 13
CAT 13
ammonium 12
quinoline 12
MDR 12
formaldehyde 12
AMP 12
quinoline 12
tryptophan 12
Trichloroethylene 12
betaine 12
NH2 12
more...