Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0345904 (
liver cancer
)
15,188
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ginsenoside Rg3, a naturally occurring phytochemical, serves an important role in the prevention and treatment of cancer. In the present study, with the aim to reveal the molecular mechanism of Rg3 in
liver cancer
cell metastasis, the anti-migration and anti-invasion effects of Rg3 on
liver cancer
cells were investigated. It was demonstrated that Rg3 caused marked inhibition of cell migration and invasion of human
liver cancer
cells, HepG2 and MHCC-97L,
in vitro
, and the growth of HepG2 and MHCC-97L tumors in BABL/c nude mice. The protein expression of
Rho GTPase activating protein 9
(
ARHGAP9
) was increased both in HepG2 and MHCC-97L cells. Following
ARHGAP9
knockdown, the results of Transwell and tumorigenesis assays revealed that the anti-migration, anti-invasion and anti-tumor growth effects of Rg3 were impaired significantly. The increased expression of
ARHGAP9 protein
induced by Rg3 was remarkably suppressed. All results suggested that
ARHGAP9 protein
may be a vital regulator in the anti-metastatic role of Rg3. To the best of our knowledge, the present study is the first to report that Rg3 effectively suppressed the migration and invasion of
liver cancer
cells by upregulating the protein expression of
ARHGAP9
, indicating a novel natural therapeutic agent and a therapeutic target for the treatment of
liver cancer
.
...
PMID:Ginsenoside Rg3 inhibits the migration and invasion of liver cancer cells by increasing the protein expression of ARHGAP9. 3065 55
