Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0345904 (
liver cancer
)
15,188
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Activation of YAP/TEAD signaling is very common in the progression of
HCC
(Hepatocellular carcinoma). Nuclear pore complex (NPC) regulates the shuttling of proteins between cytoplasm and nucleus. Nuclear accumulation of YAP protein has been observed in the majority of
HCC
tissues. However, whether NPC could regulate the YAP/TEAD signaling remains unknown. In this study, it was found
NUP37
, the component of NPC, significantly up-regulated in
HCC
clinical samples and mouse model. Over-expression of
NUP37
promoted the growth, migration and invasion of
HCC
cells, while knocking down the expression of
NUP37
inhibited the growth, migration, invasion and metastasis of
HCC
cells and improved the survival of the mouse model.
NUP37
interacted with YAP and activated YAP/TEAD signaling by enhancing the interaction between YAP and TEAD. Taken together, these data demonstrated the oncogenic roles of
NUP37
in the progression of
HCC
and suggested that
NUP37
might be a promising therapeutic target.
...
PMID:NUP37, a positive regulator of YAP/TEAD signaling, promotes the progression of hepatocellular carcinoma. 2922 69
